Search results for "Computer Science Applications"

Functional evaluation of a “lingual ring” oral device applied on patients affected by temporo-mandibular disorders tmds: A comparative clinical trial

2021

This study aims to evaluate the functional variations of the electromyographic response and clinical symptomatology in TMD patients. This study has been performed and compared before and after the application of a therapeutic protocol based on the use of an oral device working on the proper mandibular repositioning through the proprioceptive-based lingual re-education called “Lingual Ring”. Between January to December 2016, 32 TMD patients have been recruited out of a series of 321 individuals recruited at the Neurosensorial and Motorial Surgery Department, in Palermo (Italy). All the patients underwent the Surface Electromyography (sEMG) of Masseter and Temporal muscles, with different reg…

Selecting the best risk measure in multiobjective cash management

2018

Agents and robots for collaborating and supporting physicians in healthcare scenarios

2020

Graphical abstract

2021

Four drugs are currently approved for the treatment of Alzheimer’s disease (AD) by the FDA. Three of these drugs—donepezil, rivastigmine, and galantamine—belong to the class of acetylcholine esterase inhibitors. Memantine, a NMDA receptor antagonist, represents the fourth and a combination of donepezil and memantine the fifth treatment option. Recently, the gut and its habitants, its microbiome, came into focus of AD research and added another important factor to therapeutic considerations. While the first data provide evidence that AD patients might carry an altered microbiome, the influence of administered drugs on gut properties and commensals have been largely ignored so far. However, t…

HR1 Robot: An Assistant for Healthcare Applications

2022

According to the World Health Organization1,2 the percentage of healthcare dependent population, such as elderly and people with disabilities, among others, will increase over the next years. This trend will put a strain on the health and social systems of most countries. The adoption of robots could assist these health systems in responding to this increased demand, particularly in high intensity and repetitive tasks. In a previous work, we compared a Socially Assistive Robot (SAR) with a Virtual Agent (VA) during the execution of a rehabilitation task. The SAR consisted of a humanoid R1 robot, while the Virtual Agent represented its simulated counter-part. In both cases, the agents evalua…

Modelling net radiation at surface using “in situ” netpyrradiometer measurements with artificial neural networks

2011

The knowledge of net radiation at the surface is of fundamental importance because it defines the total amount of energy available for the physical and biological processes such as evapotranspiration, air and soil warming. It is measured with net radiometers, but, the radiometers are expensive sensors, difficult to handle, that require constant care and also involve periodic calibration. This paper presents a methodology based on neural networks in order to replace the use of net radiometers (expensive tools) by modeling the relationships between the net radiation and meteorological variables measured in meteorological stations. Two different data sets (acquired at different locations) have…

Broadband Internet Access via Multi-Hop Wireless Mesh Networks: Design, Protocol and Experiments

2010

Published version of an article from the journal: Wireless Personal Communications. The original publication is available at Spingerlink. http://dx.doi.org/10.1007/s11277-009-9907-9 While bandwidth for Internet access in urban areas is steadily increasing in recent years, many rural areas are still suffering from the effect of the digital divide. This paper presents a broadband Internet access paradigm developed in the context of the ADHOCSYS project, which was financed by the European Commission under the 6th Framework Program Information and Society Technologies, within the strategic objective of Broadband for All. Aiming at providing reliable Internet access in rural and mountainous regi…

In Silico Design of New Dual Inhibitors of SARS-CoV-2 MPRO through Ligand- and Structure-Based Methods

2023

The viral main protease is one of the most attractive targets among all key enzymes involved in the life cycle of SARS-CoV-2. Considering its mechanism of action, both the catalytic and dimerization regions could represent crucial sites for modulating its activity. Dual-binding the SARS-CoV-2 main protease inhibitors could arrest the replication process of the virus by simultaneously preventing dimerization and proteolytic activity. To this aim, in the present work, we identified two series’ of small molecules with a significant affinity for SARS-CoV-2 MPRO, by a hybrid virtual screening protocol, combining ligand- and structure-based approaches with multivariate statistical analysis. The B…

Health app policy:international comparison of nine countries' approaches

2022

An abundant and growing supply of digital health applications (apps) exists in the commercial tech-sector, which can be bewildering for clinicians, patients, and payers. A growing challenge for the health care system is therefore to facilitate the identification of safe and effective apps for health care practitioners and patients to generate the most health benefit as well as guide payer coverage decisions. Nearly all developed countries are attempting to define policy frameworks to improve decision-making, patient care, and health outcomes in this context. This study compares the national policy approaches currently in development/use for health apps in nine countries. We used secondary d…

Protective, antioxidant and antiproliferative activity of grapefruit integropectin on sh-sy5y cells

2021

Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have open…