Search results for "Computer Science Applications"
showing 10 items of 3993 documents
In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach
2011
In the present study, 21 validated QSAR models that discriminate compounds with high Caco-2 permeability (Papp ≥8×10(-6) cm/s) from those with moderate-poor permeability (Papp <8×10(-6) cm/s) were developed on a novel large dataset of 674 compounds. 20 DRAGON descriptor families were used. The global accuracies of obtained models were ranking between 78-82 %. A general model combining all types of molecular descriptors was developed and it classified correctly 81.56 % and 83.94 % for training and test sets, respectively. An external set of 10 compounds was predicted and 80 % was correctly assessed by in vitro Caco-2 assays. The potential use of the final model was evaluated by a virtual s…
Modeling anti-allergic natural compounds by molecular topology.
2013
Molecular topology has been applied to the search of QSAR models able to identify the anti-allergic activity of a wide group of heterogeneous compounds. Through the linear discriminant analysis and artificial neural networks, correct classification percentages above 85% for both the training set and the test set have been obtained. After carrying out a virtual screening with a natural product library, about thirty compounds with theoretical anti-allergic activity have been selected. Among them, hesperidin, naringin, salinomycin, sorbitol, curcumol, myricitrin, diosmin and kinetin stand out. Some of these compounds have already been referenced as having anti-allergic activity.
Replication of Human Norovirus in Mice after Antibiotic-Mediated Intestinal Bacteria Depletion
2022
Human noroviruses (HuNoVs) are the main cause of acute gastroenteritis causing more than 50,000 deaths per year. Recent evidence shows that the gut microbiota plays a key role in enteric virus infectivity. In this context, we tested whether microbiota depletion or microbiota replacement with that of human individuals susceptible to HuNoVs infection could favor viral replication in mice. Four groups of mice (n = 5) were used, including a control group and three groups that were treated with antibiotics to eliminate the autochthonous intestinal microbiota. Two of the antibiotic-treated groups received fecal microbiota transplantation from a pool of feces from infants (age 1-3 months) or an au…
Digital educational resources in early childhood Education
2022
[Resumen] El impacto de las tecnologías en la población infantil de 3 a 6 años es evidente tanto en el contexto familiar como el educativo, donde los docentes asumen un rol fundamental en la selección, uso y creación de recursos didácticos digitales. El objetivo de este trabajo consiste en analizar las visiones del profesorado sobre los usos didácticos y organizativos de la tecnología en general y de los Recursos Educativos Digitales en particular, y la valoración tras su introducción y puesta en práctica en la etapa de Educación Infantil. En este estudio de corte cualitativo se empleó como instrumento de recogida de la información una entrevista semiestructurada a un total de 15 docentes q…
A heterogeneous and reconfigurable machine-vision system
1995
This paper describes a new machine-vision system, a HERMIA heterogeneous and reconfigurable machine for image analysis. The architecture topology of the HERMIA machine is reconfigurable; moreover, the integration of its special modules allows a search for optimal strategies to solve vision problems. The general architecture and the hardware implementation are described. The software environment of the HERMIA machine provides a full iconic interface and a pictorial language oriented to vision in multiprocessor architectures. The preliminary system evaluation and applications are shown. © 1995 Springer-Verlag.
A Posture Sequence Learning System for an Anthropomorphic Robotic Hand
2003
The paper presents a cognitive architecture for posture learning of an anthropomorphic robotic hand. Our approach is aimed to allow the robotic system to perform complex perceptual operations, to interact with an human user and to integrate the perceptions by a cognitive representation of the scene and the observed actions. The anthropomorphic robotic hand imitates the gestures acquired by the vision system in order to learn meaningful movements, to build its knowledge by different conceptual spaces and to perform complex interaction with the human operator.
CheS-Mapper 2.0 for visual validation of (Q)SAR models
2014
Abstract Background Sound statistical validation is important to evaluate and compare the overall performance of (Q)SAR models. However, classical validation does not support the user in better understanding the properties of the model or the underlying data. Even though, a number of visualization tools for analyzing (Q)SAR information in small molecule datasets exist, integrated visualization methods that allow the investigation of model validation results are still lacking. Results We propose visual validation, as an approach for the graphical inspection of (Q)SAR model validation results. The approach applies the 3D viewer CheS-Mapper, an open-source application for the exploration of sm…
Visualizations for Decision Support in Scenario-based Multiobjective Optimization
2021
Reproducibility artifacts for: Babooshka Shavazipour, Manuel López-Ibáñez, and Kaisa Miettinen. Visualizations for Decision Support in Scenario-based Multiobjective Optimization. Information Sciences, 2021. doi:10.1016/j.ins.2021.07.025. Abstract: We address challenges of decision problems when managers need to optimize several conflicting objectives simultaneously under uncertainty. We propose visualization tools to support the solution of such scenario-based multiobjective optimization problems. Suitable graphical visualizations are necessary to support managers in understanding, evaluating, and comparing the performances of management decisions according to all objec…
Cantus: Construction and evaluation of a software solution for real-time vocal music training and musical intonation assessment
2016
The development of the ability to sing or play in tune is one of the most critical tasks in music training. In music education, melodic patterns are usually learned by imitative processes (modelling). Once modelled, pitch sounds are then associ-ated to a representation according to a syllabic system such as the Guidonian system - or an arbitrary single syllable - or western graphic notation system symbols. From a didactic standpoint, few advances have been made in this area besides the use of audio-supported guides and existing software, which use a microphone to analyse the input and estimate the pitch or fundamental frequency of the given tone. However, these programmes lack the necessary…
The bridge volcanic LIdar-BILLI: A review of data collection and processing techniques in the Italian most hazardous volcanic areas
2020
Volcanologists have demonstrated that carbon dioxide (CO2) fluxes are precursors of volcanic eruptions. Controlling volcanic gases and, in particular, the CO2 flux, is technically challenging, but we can retrieve useful information from magmatic/geological process studies for the mitigation of volcanic hazards including air traffic security. Existing techniques used to probe volcanic gas fluxes have severe limitations such as the requirement of near-vent in situ measurements, which is unsafe for operators and deleterious for equipment. In order to overcome these limitations, a novel range-resolved DIAL-Lidar (Differential Absorption Light Detection and Ranging) has been developed as part of…