Search results for "Computer Science"

Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker

2013

We characterized the oxidative stress (OS) status by the levels of reduced/oxidized glutathione (GSH/GSSG), malondialdehyde (MDA) and the mutagenic base 8-oxo-7′8-dihydro-2′-deoxyguanosine (8-oxo-dG) in human gastric carcinoma (HGC) samples and compared the results with normal tissue from the same patients. We also analyzed 8-oxo-dG in peripheral mononuclear cells (PMNC) and urine from healthy control subjects and in affected patients in the basal state and one, three, six, nine and twelve months after tumor resection. The levels of DNA repair enzyme mRNA expression (hOGG1, RAD51, MUYTH and MTH1) were determined in tumor specimens and compared with normal mucosa. Tumor specimens exhibited i…

Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography

2012

Background With its high spatial and temporal resolution, optical coherence tomography (OCT) is an ideal modality for intra-operative imaging. One possible application is to detect tumour invaded tissue in neurosurgery, e.g. during complete resection of glioblastoma. Ideally, the whole resection cavity is scanned. However, OCT is limited to a small field of view (FOV) and scanning perpendicular to the tissue surface. Methods We present a new method to use OCT for scanning of the resection cavity during neurosurgical resection of brain tumours. The main challenges are creating a map of the cavity, scanning perpendicular to the surface and merging the three-dimensional (3D) data for intra-ope…

Endovascular management of a giant symptomatic gluteal artery aneurysm with selective arterial embolization

2017

A 78-year-old female presented to our department with pain and swelling in the left gluteal region. Physical examination revealed a large tender swelling in the left gluteal area simulating an abscess. However, pulsation was observed over the swelling that raised the suspicion of a vascular lesion. Therefore, contrast-enhanced computed tomography (CT) was done before trying any intervention. The scan demonstrated a large aneurysm originating from the left superior gluteal artery measuring 65 mm × 38 mm with a small intra-pelvic component and large extra-pelvic component in the gluteal area ( Figure 1 ).

Neural Networks for Modeling the Contact Foot-Shoe Upper

2010

Recently, important advances in virtual reality have made possible real improvements in computer aided design, CAD. These advances are being applied to all the fields and they have reached to the footwear design. The majority of the interaction foot-shoe simulation processes have been focused on the interaction between the foot and the sole. However, few efforts have been made in order to simulate the interaction between the shoe upper and the foot surface. To simulate this interaction, flexibility tests (characterization of the relationship between exerted force and displacement) are carried out to evaluate the materials used for the shoe upper. This chapter shows a procedure based on arti…

Ein rechnerunterstütztes elektromechanisches Meßsystem zur Untersuchung der Flexions- und Extensionskraft im oberen Sprunggelenk

2008

Mathematical Modeling for Neuropathic Pain: Bayesian Linear Regression and Self-Organizing Maps Applied to Carpal Tunnel Syndrome

2020

A better understanding of the connection between risk factors associated with pain and function may assist therapists in optimizing therapeutic programs. This study applied mathematical modeling to analyze the relationship of psychological, psychophysical, and motor variables with pain, function, and symptom severity using Bayesian linear regressions (BLR) and self-organizing maps (SOMs) in carpal tunnel syndrome (CTS). The novelty of this work was a transfer of the symmetry mathematical background to a neuropathic pain condition, whose symptoms can be either unilateral or bilateral. Duration of symptoms, pain intensity, function, symptom severity, depressive levels, pinch tip grip force, a…

The Symmetry of Lower Back Pain as a Potential Screening Factor for Serious Pathology: A Survey Study

2021

Background: Pain maps provide reliable information on pain location in various conditions. This study explored the feasibility of pain maps as a screening tools for serious underlying conditions. The pain symmetry was evaluated as the possible distinguishing feature. Methods: A Web-based survey on the correlation of pain-related disability and pain pattern was developed. Respondents with lower back pain were asked to mark the exact location of their pain over the pain chart. The symmetry index was calculated and used to divide subjects into two groups that were then compared in terms of the prevalence of red flags for serious pathologies, as well as the pain-related disability measured with…

Development of a Protocol for CCD Calibration: Application to a Multispectral Imaging System

2005

In this paper we describe in detail a method for calibrating a CCD-based camera. The calibration aims to remove both temporal and systematic noises introduced by the sensor, electronics, and optics after which we can correct the non-linearity of its response. For the non-linearity correction we use a simple and powerful approach consisting on a complementary approach between a polynomial fitting and an LUT based algorithm. The proposed methodology is accurate in the sense that it takes into account individual characteristics of each pixel. In each pixel, systematic noises are measured through acquiring offset images, thermal images, and FlatField images. A rigorous protocol for acquiring th…

Patient Profiling Based on Spectral Clustering for an Enhanced Classification of Patients with Tension-Type Headache

2020

Profiling groups of patients in clusters can provide meaningful insights into the features of the population, thus helping to identify people at risk of chronification and the development of specific therapeutic strategies. Our aim was to determine if spectral clustering is able to distinguish subgroups (clusters) of tension-type headache (TTH) patients, identify the profile of each group, and argue about potential different therapeutic interventions. A total of 208 patients (n = 208) with TTH participated. Headache intensity, frequency, and duration were collected with a 4-week diary. Anxiety and depressive levels, headache-related burden, sleep quality, health-related quality of life, pre…

Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?

2021

Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients’ clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy and minimizing toxicity. This is of great importance, especially in pediatric cancer and even more in complex malignancies such as neuroblastoma, where the rates of therapeutic success are still below those of many other types of tumors. The studies are mainly focused on germline genetic variants and in the present review, state of the art is presented: which are the variants that have a level of evidence high enough to be implemented in the c…