Search results for "Computer simulation"
showing 10 items of 1054 documents
Experimental study and numerical simulation of inclined rectangular weirs
2018
Inclined rectangular weirs, also named pivot weirs, are used both to adjust the upstream water level and to increase the flow capacity compared with that of normal rectangular weirs. However, the experimental studies available in the literature present contradictory conclusions for the inclined weir discharge capacity. In this paper, new experimental runs and numerical simulations were performed to investigate the effect of the rectangular weir inclination angle on the stage-discharge formula. The experiments were carried out using inclination angles ranging from 30° to 90°. Buckingham's theorem of dimensional analysis was used to obtain an equation for the flow magnification ratio (the dis…
Robust control for high performance induction motor drives based on partial state-feedback linearization
2019
This paper deals with a robust input-output feedback linearization control technique for induction motors. Indeed, classic feedback linearization presents two main disadvantages: 1) the accuracy of the dynamic model; and 2) the corresponding correct knowledge of the model parameters. To address this issue, the linear controller has been substituted with a suitably controller designed to be robust to the variations of the main parameters of the induction motor, like stator and rotor resistances, and the three-phase magnetizing inductance. The proposed controller has been tested both in numerical simulation and experimentally on a suitably designed test setup. Moreover, it has been compared w…
Modelling and Simulation of Machining Processes and Operations
2008
This chapter provides the state-of-the-art knowledge engineering and modelling techniques applied in manufacturing/machining and overviews future trends observed at a global scale. Modelling methods for machining processes and operations are classified. The chapter also highlights the multiple tasks of modelling and simulation in modern machining/manufacturing systems. The most popular techniques of numerical simulation including finite difference method and finite element method (FEM) related to mechanical and thermal problems arising in machining processes are described. Practical examples of FE models of various metal cutting operations and their importance in modern manufacturing are pr…
Process mechanics in Friction Stir Extrusion of magnesium alloys chips through experiments and numerical simulation
2017
Abstract Friction Stir Extrusion (FSE) is a novel process designed to directly recycle machining chips. An experimental campaign was carried out on AZ31 milling chips using variations in extrusion ratio, force and tool rotation rate. The process mechanics were studied and correlated to the material flow, which was elucidated through use of a copper marker. A 3D, Lagrangian, thermo-mechanically coupled dedicated numerical model was set up and validated through temperature measurements. The combination of experimental and numerical results permitted to reconstruct the complex 3D material flow induced by tool rotation and plunge into the extrusion billet chamber.
Numerical Study about the Influence of Wall Angle about Main Strains, Thickness Reduction and Forces on Single Point Incremental Forming Process
2016
Abstract The current paper aims to study, using numerical simulation, the influence of the wall angle on the single point incremental forming process. For the analysis there has been used the LS-Dyna software and three explicit dynamic analyses were run for three parts with wall angles of 450, 550 and 650. The factors taken into account are the main strains, the thickness reduction and the forces on three directions. The material data introduced into the simulation were determined based on an uniaxial traction test on an Instron 5587 testing machine and the Aramis system was used as optical extensometer.
The numerical simulation of heat transfer during a hybrid laser–MIG welding using equivalent heat source approach
2014
International audience; The present study is dedicated to the numerical simulation of an industrial case of hybrid laser-MIG welding of high thickness duplex steel UR2507Cu with Y-shaped chamfer geometry. It consists in simulation of heat transfer phenomena using heat equivalent source approach and implementing in finite element software COMSOL Multiphysics. A numerical exploratory designs method is used to identify the heat sources parameters in order to obtain a minimal required difference between the numerical results and the experiment which are the shape of the welded zone and the temperature evolution in different locations. The obtained results were found in good correspondence with …
In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations …
2016
Several drugs used for the treatment of colorectal cancer (CRC) are targeted at the epidermal growth factor receptor, but mutations in genes of the RAS family cause resistance to these drugs. Thus, extensive research is being carried out to counterbalance this resistance. The G13D mutation of KRAS is common in humans, and we previously reported that this mutation results in the epigenetic modification of hnRNP proteins, involved in RNA splicing. As aberrant splicing often results in oncogenicity, the present study aimed to identify the genes which show altered splicing patterns in connection with the G13D KRAS mutation. To accomplish this, we first carried out an in silico analysis of RNA-s…
Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis.
2018
Summary: Adult murine neural stem cells (NSCs) generate neurons in drastically declining numbers with age. How cellular dynamics sustain neurogenesis and how alterations with age may result in this decline are unresolved issues. We therefore clonally traced NSC lineages using confetti reporters in young and middle-aged adult mice. To understand the underlying mechanisms, we derived mathematical models that explain observed clonal cell type abundances. The best models consistently show self-renewal of transit-amplifying progenitors and rapid neuroblast cell cycle exit. In middle-aged mice, we identified an increased probability of asymmetric stem cell divisions at the expense of symmetric di…
Evolution of Ciona intestinalis Tumor necrosis factor alpha ( Ci TNFα): Polymorphism, tissues expression, and 3D modeling
2017
Although the Tumor necrosis factor gene superfamily seems to be very conserved in vertebrates, phylogeny, tissue expression, genomic and gene organization, protein domains and polymorphism analyses showed that a strong change has happened mostly in invertebrates in which protochordates were a constraint during the immune-molecules history and evolution. RT PCR was used to investigate differential gene expression in different tissues. The expression shown was greater in the pharynx. Single-nucleotide polymorphism has been investigated in Ciona intestinalis Tumor necrosis factor alpha (CiTNFα) mRNA isolated from the pharynx of 30 ascidians collected from Licata, Sicily (Italy), by denaturing …
Drugs Polypharmacology by in Silico Methods: New Opportunities in Drug Discovery
2016
Background Polypharmacology, defined as the modulation of multiple proteins rather than a single target to achieve a desired therapeutic effect, has been gaining increasing attention since 1990s, when industries had to withdraw several drugs due to their adverse effects, leading to permanent injuries or death, with multi-billiondollar legal damages. Therefore, if up to then the "one drug one target" paradigm had seen many researchers interest focused on the identification of selective drugs, with the strong expectation to avoid adverse drug reactions (ADRs), very recently new research strategies resulted more appealing even as attempts to overcome the decline in productivity of the drug dis…