Search results for "Computer"

Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice

2020

Drug research, therapy development, and other areas of pharmacology and medicine can benefit from simula- tions and optimization of mathematical models that contain a mathematical description of interactions between systems elements at the cellular, tissue, organ, body, and population level. This approach is the foundation of systems medicine and precision medicine. Here, simulated experiments are performed with computers (in silico) first, and they are then replicated through lab experiments (in vivo or in vitro) or clinical studies. In turn, these experiments and studies can be used to validate or improve the models. This iterative loop of dry and wet lab work is successful when biomedica…

Atlas: analysis tools for low-depth and ancient samples

2017

AbstractSummaryPost-mortem damage (PMD) obstructs the proper analysis of ancient DNA samples and can currently only be addressed by removing or down-weighting potentially damaged data. Here we present ATLAS, a suite of methods to accurately genotype and estimate genetic diversity from ancient samples, while accounting for PMD. It works directly from raw BAM files and enables the building of complete and customized pipelines for the analysis of ancient and other low-depth samples in a very user-friendly way. Based on simulations we show that, in the presence of PMD, a dedicated pipeline of ATLAS calls genotypes more accurately than the state-of-the-art pipeline of GATK combined with mapDamag…

Pathophysiology of Grey Matter Affection in MS

2021

Appendix A: Fundamentals of statistics

2008

Optical multichannel monitoring of skin blood pulsations for cardiovascular assessment

2004

Time resolved detection and analysis of the skin back-scattered optical signals (reflection photoplethysmography or PPG) provide rich information on skin blood volume pulsations and can serve for cardiovascular assessment. The multichannel PPG concept has been developed and clinically verified in this work. Simultaneous data flow from several body locations allows to study the heartbeat pulse wave propagation in real time and to evaluate the vascular resistance. Portable two- and four-channel PPG monitoring devices and special software have been designed for real-time data acquisition and processing. The multi-channel devices were successfully applied for cardiovascular fitness tests and fo…

Artificial Neural Network Based Abdominal Organ Segmentations: A Review

2015

There are many neural network based abdominal organ segmentation approaches from medical images. Computed tomography images were mostly used in these approaches. Applied techniques are usually based on prior information regarding position, shape, and size of organs in these methods. In the literature, there are only a few neural network based techniques that were implemented to segment abdominal organs from magnetic resonance based images. In this paper, we present these methods and their results.

EEG-based biometrics: effects of template ageing

2020

This chapter discusses the effects of template ageing in EEG-based biometrics. The chapter also serves as an introduction to general biometrics and its main tasks: Identification and verification. To do so, we investigate different characterisations of EEG signals and examine the difference of performance in subject identification between single session and cross-session identification experiments. In order to do this, EEG signals are characterised with common state-of-the-art features, i.e. Mel Frequency Cepstral Coefficients (MFCC), Autoregression Coefficients, and Power Spectral Density-derived features. The samples were later classified using various classifiers, including Support Vecto…

Functional Magnetic Resonance Imaging (fMRI)

2017

Comparative assessment of brain activity during depth perception of stereoscopic and volumetric images

2020

Recent advancements in visualization systems have triggered a growing demand for the objective and accurate comparison of user cognitive requirements when perceiving three-dimensional images demonstrated in different ways. In this work, we present the first comparative assessment of brain activity in subjects viewing stereoscopic images and volumetric images. Electroencephalography was employed to assess the short-term changes in event related potentials and neural oscillations which were further interpreted in terms of cognitive requirements for relative depth judgments. As a result, considerably higher activity have been registered in the beta band and gamma band in case of judging relati…

2019

(1) Background: The high-grade neuroepithelial tumor of the central nervous system with BCOR alteration (HGNET-BCOR) is a highly malignant tumor. Preclinical models and molecular targets are urgently required for this cancer. Previous data suggest a potential role of insulin-like growth factor (IGF) signaling in HGNET-BCOR. (2) Methods: The primary HGNET-BCOR cells PhKh1 were characterized by western blot, copy number variation, and methylation analysis and by electron microscopy. The expression of IGF2 and IGF1R was assessed by qRT-PCR. The effect of chemotherapeutics and IGF1R inhibitors on PhKh1 proliferation was tested. The phosphorylation of IGF1R and downstream molecules was assessed …