Search results for "Computer"
showing 10 items of 30657 documents
The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
2021
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy and safety aspects, (pre-)clinical experimental approaches evaluate the respective modes of action (MoA). In addition to antigen-specificity including binding affinity and -avidity, MoA comprise Fc-mediated effector functions such as antibody dependent cellular cytotoxicity (ADCC) and the closely related antibody dependent cellular phagocytosis (ADCP). For this reason, a variety of cell-based assays have…
Simafield : Un logiciel de modélisation spatiale de scènes agronomiques
2013
Environmental measures lead farmers to use more and more decision support tools to reduce their chemical inputs without losing yield. Imaging system based on crop/weed discrimination algorithms have been developed to detect weeds in field and allow a site specific spraying. These algorithms needs to be thoroughly evaluated before considering a public release and current evaluation are based on real images and are very tedious. SimAField is a software that aims at modeling agronomic fields with crop and weeds and simulate the picture taking process to replace ground truth and allow an automated evaluation of crop/weed discrimination algorithms.
Le numérique à l’université : facteur explicatif des méthodes pédagogiques ?
2018
Cet article a une double ambition. Il vise premièrement à mettre l’accent sur les méthodes pédagogiques déployées à l’université par les enseignants en cours magistral et en travaux pratiques et travaux dirigés. Il s’intéresse dans un second temps à l’utilisation du numérique par les enseignants, pendant et en dehors des heures de cours, comme facteur explicatif des méthodes pédagogiques mises en place. Ainsi, à partir des données recueillies au travers une enquête empirique menée auprès d’un échantillon composé de 248 enseignants d’une université française, nous proposons une description des méthodes pédagogiques mobilisées par ces derniers. Puis, nous avons construit des modèles de régres…
Analyse numérique MIGS 1re Année
2021
Il s'agit d'un cours d'analyse numérique qui a été dispensé à l'Université de Bourgogne en Master MIGS 1re Année (en 2019-2020, et 2020-2021). Il traite principalement de la résolution itérative de systèmes linéaires symétriques par gradient conjugué, et aussi de la résolution de systèmes linéaires mal posés par moindres carrés. Il vient en complément aux cours d'analyse numérique et d'optimisation que les étudiants ont suivi auparavant.
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
Functional Extrapolations to Tame Unbound Anions in Density-Functional Theory Calculations
2019
Standard flavors of density-functional theory (DFT) calculations are known to fail in describing anions, due to large self-interaction errors. The problem may be circumvented using localized basis sets of reduced size, leaving no variational flexibility for the extra electron to delocalize. Alternatively, a recent approach exploiting DFT evaluations of total energies on electronic densities optimized at the Hartree-Fock (HF) level has been reported, showing that the self-interaction-free HF densities are able to lead to an improved description of the additional electron, returning affinities in close agreement with the experiments. Nonetheless, such an approach can fail when the HF densitie…
Regional currencies and regional monetary zones in Latin America : what prospects ?
2009
9 p.; This paper aims at drawing lessons from Keynes's plan presented at the Bretton Woods conference, in order to help improving current regional monetary agreements in Latin America. Some promoters of the Bank of the South and the New Financial Architecture in Latin America are proposing to implement a regional clearing system designed to allow a multilateral offsetting of the liabilities and assets generated in the reciprocal transactions of member countries in words that the British economist certainly would not have denied. This system would be very different from current regional payments aggreements that maintain an implicit reference to the US dollar as reserve or payment currency.
Toimijuus ja asiantuntijaksi kasvaminen monimediaisessa kielenopettamisessa
2011
This case study investigates the role of agency in the development of two students’ expertise during their participation in the year-long KOO-KIT program (Language Technology for Language Teachers) for pre-service language teachers at the Centre for Applied Language Studies of the University of Jyväskylä in the 2000s. The curriculum of the program was organized around project-based learning, with theoretical and pedagogical lessons and hands-on technology courses alternating with practical team work in web-based design. The data consist of the teachers’ observations and narrative assessments of the students’ performance, and the students’ self-reports during the one-year course. The finding…
Enhancing the performance of HSDPA communication with multipoint transmission techniques
2015
The evolution of mobile phones, tablets and other mobile communication devices has led to a significant increase in the amount of data delivered over mobile networks. In order to satisfy the climbing data rate demands of customers, existing mobile broadband networks are being expanded with new features that allow ubiquitous and consistent networking experience. This research presents three multipoint transmission techniques for Wideband Code Division Multiple Access (WCDMA) based High-Speed Downlink Packet Access (HSDPA) communication protocol. Multiflow, High-Speed Single-Frequency Network (HS-SFN) and Multipoint-to-Point Single-Frequency Network (M2P-SFN) enable transmission of user-dedicat…
A Pilot Study on Developing Newsgames in Collaboration between Journalism and Computer Science Students
2019
Abstract Producing digital and interactive journalistic products offers unique and important new learning opportunities for journalism education. This study analysed the experiences of two pilot courses on so-called ‘newsgames’ in a Finnish university in 2015 and 2017. The data consisted of the newsgames and other materials produced by the students, student feedback concerning the course and observations of teachers throughout the project. Our analysis demonstrates how producing newsgames in the context of higher education may foster project-based learning experiences, something that has been relatively rare in traditional journalism education. Collaboration with media companies also offere…