Search results for "Concomitant"
showing 10 items of 248 documents
Serum eosinophil cationic protein as a potential biomarker for interleukin-5 antibody treatment in patients with severe uncontrolled eosinophilic ast…
2018
Serum eosinophil cationic protein (ECP) has been described as a marker reflecting activation of eosinophils in asthma, potentially correlating to airway inflammation. Our aim was to examine the role of serum ECP to predict treatment efficacy in asthmatics starting interleukin-5 antibody (anti-IL5) therapy. We evaluated 65 patients with severe, uncontrolled eosinophilic asthma (≥300 eosinophils per µl blood) before and approx. 4 months after initiation of anti-IL5 therapy with mepolizumab; 35 patients completed a 12 month follow-up. Evaluation of treatment efficacy included medical history, asthma questionnaires, physical examination, spirometry, exhaled NO and blood tests. Depending on the …
THERAPEUTIC EFFICACY OF MAGNESIUM VALPROATE IN SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY
2012
Succinic semialdehyde dehydrogenase deficiency (SSADHD or gammahydroxybutyric aciduria), a disorder of γ-aminobutyric acid (GABA) metabolism, manifests as a slowly progressive or static encephalopathy. The latter encompasses prominent cognitive dysfunction, neuropsychiatric morbidity and epilepsy.We report safe and effective treatment with MgVPA in an adolescent female with SSADHD and seizures refractory to a broad spectrum of antiepileptics. MgVPA therapy (20 mg/Kg/day) was introduced at 7 years based upon behavioural difficulties and EEG alterations without adverse effects. Therapy was halted at age 13 years, and reintroduced at 14 years, due to new onset complex partial seizures. EEG dem…
Giustizia ambientale e recupero delle aree verdi: il caso di Palermo
2021
L’urban shrinkage è diventata una questione centrale tanto nel dibattito scientifico quanto nell’agenda politica di diverse città europee. Secondo i dati EUROSTAT (2019), circa il 40% delle città europee con più di 200.000 abitanti stanno perdendo popolazione; una contrazione che si esplicita maggiormente, sotto il profilo spaziale, in una progressiva sottoutilizzazione del patrimonio edificato, così come nel contestuale incremento di aree e terreni in stato di abbandono. In questo quadro controverso di mutazione strutturale della città, così come l’abbiamo conosciuta, le politiche urbane alla prova in Europa tentano di declinare la decrescita quale occasione strategica di investimento sull…
Bone Density, Balance and Quality of Life of Postmenopausal Women Taking Alendronate Participating in Different Physical Activity Programs
2010
Made available in DSpace on 2022-04-28T19:04:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Background: The objective of this study was to determine the effects of different physical activity (PA) programs on bone density, balance and quality of life of postmenopausal women taking concomitant alendronate. A quasi-experimental study was conducted with 35 volunteers divided into four groups: practitioners of resistance training (RTG, n = 9, 49.8±4.2 years), judo (JUG, n = 11, 52.2±5.3 years), water aerobics (WAG, n = 8, 57.1±7.4 years) and the control group (CG, n = 7, 53.8±4.4 years). Methods: The following assessment tools were used: bone mineral density (BMD) measured by d…
Proximal vertebral artery surgery. Results of treatment of ischemia of the rhombencephalon (hindbrain). Simultaneous carotid and vertebral artery dec…
2022
Surgical treatment of hindbrain ischemia is becoming the accepted surgical procedure in cases of stenosis of extracranial segments of vertebral arteries in the course of advanced atherosclerotic lesions in their initial segments (V1) or caused by external compression of these arteries in the canal formed by the transverse processes of cervical vertebrae. The latter is referred to as vertebrobasilar insufficiency (VBI). The transposition of the left vertebral artery to the common carotid artery in cases where stent graft implantation is necessary with coverage of the subclavian artery and possible blood supply disorders of both the hindbrain and the spinal cord has become important. In the D…
The Severe Asthma Registry – German data
2018
Patients with severe persistent asthma represent the highest unmet medical need among the asthmatic population. To improve the understanding of underlying mechanisms and disease progression the German Asthma Net (GAN, www.german-asthma-net.de) launched a Severe Asthma Registry in December 2011. Enrolled patients undergo detailed clinical and physiologic evaluations, including patients’ medical history, allergy and lung function tests, blood analyses as well as past and concomitant medication and comorbidities. Patients are followed up every year. As of February 2018, 1097 subjects were recruited in Germany, Austria, and Slovenia. The mean age±SEM of the 839 German adult patients is 50.6±0.5…
Novel Perspectives in the Detection of Oral and Nasal Oxidative Stress and Inflammation in Pediatric United Airway Diseases
2010
United airway disease (UAD) concept proposed that asthma and rhinitis are both different clinical manifestation of a single inflammatory process. The aim of this study is to assess in upper and lower airways the level of inflammation and oxidative stress and to investigate the relationship between biomarkers in persistent allergic rhinitis (PER) and in concomitant asthma with PER. By a crosssectional study we measured oral and nasal (FENO) and oral and nasal EBC 8-isoprostane, LTB4 and PGE2 in children with PER (n=14) and with PER and concomitant intermittent asthma (IA; n=25), mild persistent asthma (mA; n=28), moderate persistent asthma (MA; n=13) and in Healthy Controls (HCs; n=13). Oral…
Data from: Interactions among bacterial strains and fluke genotypes shape virulence of co-infection
2015
Most studies of virulence of infection focus on pairwise host-parasite interactions. However, hosts are almost universally co-infected by several parasite strains and/or genotypes of the same or different species. While theory predicts that co infection favours more virulent parasite genotypes through intensified competition for host resources, knowledge of effects of genotype by genotype (G×G) interactions between unrelated parasite species on virulence of co infection is limited. Here we tested such relationship by challenging rainbow trout with replicated bacterial strains and fluke genotypes both singly and in all possible pairwise combinations. We found that virulence (host mortality) …
Potential drug-drug interaction between duloxetine and acenocoumarol in a patient with Alzheimer's disease
2007
Abstract Background : Recent evidence suggests that duloxetine may increase the effect of warfarin, thereby increasing the possibility of bleeding. However, a MEDLINE search for articles published between 1980 and May 2007 (terms: duloxetine , anticoagulants , acenocoumarol , and interaction ; no language restriction) did not yield any reports of an interaction between concomitant use of duloxetine and acenocoumarol. Objective : The aim of this study was to describe a potential drug-drug interaction between duloxetine and acenocoumarol in a patient with Alzheimer's disease. The possible mechanism of this potential interaction is examined. Case summary : This report presents the case of a 63…
Cardiorenal syndrome followed by acute hepatitis C in a patient with acute myeloid leukemia
1969
SUMMARY Cardiorenal syndrome involves altering cardiac and renal function. These patients frequently develop resistance to diuretic therapy, so that ultrafiltration should be applied in emergency for saving them. Concomitant presence of an active hematologic malignancy represents an important complicating factor. We present the case of an elderly patient with acute myeloid leukemia, appeared on the background of myelodysplastic syndrome who, during marrow aplasia occurred after the first course of induction chemotherapy, developed a cardiorenal syndrome, which required repeated sessions of hemodialysis. Complete hematologic remission and efficiency of fluid depletion therapy allowed the sec…