Search results for "Conditioning"
showing 10 items of 632 documents
Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice
2014
Exposure to social defeat stress increases the rewarding effects of psychostimulants in animal models, but its effect on 3,4-methylenedioxymethylamphetamine (MDMA) reward has received little attention. In the present study, we evaluated the influence of social defeat on the rewarding effects of MDMA in adolescent [postnatal day (PND) 29-40] and adult (PND 50-61) male mice using the conditioned place preference paradigm. Experimental mice were exposed to social defeat in an agonistic encounter before each session of conditioning with 1.25 or 10 mg/kg of MDMA. The effects of social defeat on corticosterone levels and the motor or the anxiogenic effects of MDMA were also evaluated. Mice expose…
'Up-regulation of histone acetylation induced by social defeat mediates the conditioned rewarding effects of cocaine
2016
Social defeat (SD) induces a long-lasting increase in the rewarding effects of psychostimulants measured using the self-administration and conditioned place procedures (CPP). However, little is known about the epigenetic changes induced by social stress and about their role in the increased response to the rewarding effects of psychostimulants. Considering that histone acetylation regulates transcriptional activity and contributes to drug-induced behavioral changes, we addressed the hypothesis that SD induces transcriptional changes by histone modifications associated with the acquisition of place conditioning. After a fourth defeat, H3(K9) acetylation was decreased in the hippocampus, whil…
Rewarding effects of 3,4-methylenedioxymethamphetamine (“Ecstasy”) in dominant and subordinate OF-1 mice in the place preference conditioning paradigm
2006
We tested the ability of 3,4-methylenedioxymethamphetamine (MDMA) to induce conditioned place preference (CPP) in dominant and subordinate OF-1 mice subjected to cohabitation and repeated sessions of agonistic confrontation, as well as in non-confronted mice. We selected doses of MDMA (2, 6, 10 mg/kg) previously reported to induce CPP in mice and we measured expression of c-Fos evoked by the treatments in non-confronted mice. MDMA induced c-Fos protein in several corticolimbic regions involved in drug-induced reward. Mice were exposed to brief sessions of agonistic confrontation on 5 consecutive days. Determinations of circulating hormones and drug conditioning tests were carried out on com…
Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and…
2009
Neurogenesis in the adult dentate gyrus (DG) of the hippocampus has been implicated in neural plasticity and cognition but the specific functions contributed by adult-born neurons remain controversial. Here, we have explored the relationship between adult hippocampal neurogenesis and memory function using tasks which specifically require the participation of the DG. In two separate experiments several groups of rats were exposed to fractionated ionizing radiation (two sessions of 7 Gy each on consecutive days) applied either to the whole brain or focally, aiming at a region overlying the hippocampus. The immunocytochemical assays showed that the radiation significantly reduced the expressio…
Cross-reinstatement between 3,4-methylenedioxypyrovalerone (MDPV) and cocaine using conditioned place preference.
2019
Abstract 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) considered to be a cocaine-like psychostimulant. The substitution of an established illicit drug as cocaine with an NPS is a pattern of use reported among drug users. The aim of this study was to investigate the relationship between cocaine and MDPV in the reinstatement of the conditioned place preference (CPP) paradigm, in order to establish whether there is cross-reinstatement between the two psychostimulants. Four experimental groups of male OF1 mice were subjected to the CPP paradigm: MDPV-MDPV, Cocaine-Cocaine, Cocaine-MDPV, and MDPV-Cocaine. The first drug refers to the substance with which the animal…
Learning to be a psychostimulants addict with self-regulation therapy
2018
This article presents the results of a single-case experiment of alternative treatments in which a participant applied the Self-Regulation Therapy (SRT) to reproduce the effects of a stimulant drug, methylphenidate, and a sedative, alcohol. The SRT is a learning procedure based on classic conditioning and suggestion that reproduces the effect of drugs by remembering the effects they have. The participant reproduced the effects of both drugs during ten sessions held on 5 consecutive days. To record effects, adjective scales were used that measured Drug effect, High, Rush, Energy, Tension and the General Factor of Personality (GFP). The results indicated that the participant was capable of in…
Neurobiological mechanisms of the reinstatement of drug-conditioned place preference.
2009
Drug addiction is a chronic disorder characterized by a high rate of relapse following detoxification. There are two main versions of the reinstatement model that are employed to study relapse to drug abuse; one based on the operant self-administration procedure, and the other on the classical conditioned place preference procedure. In the last seven years, the use of the latter version has become more widespread, and the results obtained complement those obtained in self-administration studies. It has been observed that the conditioned place preference induced by opioids, psychostimulants, nicotine, ethanol and other drugs of abuse can be extinguished and reinstated by drug priming or expo…
Space-time analysis of GDP disparities among European regions : a Markov chains approach
2004
The purpose of this paper is to study the evolution of the disparities between 138 European regions over the 1980-1995 period. We characterize the regional per capita GDP cross-sectional distribution by means of nonparametric estimations of density functions and we model the growth process as a first-order stationary Markov chain. Spatial effects are then introduced within the Markov chain framework using regional conditioning (Quah, 1996b) and spatial Markov chains (Rey, 2001). The results of the analysis indicate the persistence of regional disparities, a progressive bias toward a poverty trap and the importance of geography to explain the convergence process.
Activity in the rabbit somatosensory cortex reflects the active procedural memory trace of a classically conditioned eyeblink response.
2003
Behavioral responses and neural responses in the somatosensory cortex were recorded in nine rabbits during the unpaired and paired treatments of classical eyeblink conditioning with a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus. During the unpaired treatment, neither the behavioral nor neural responses to the CS were observed. During the paired treatment, behavioral conditioned response (CR), accompanied by neural activity, was developed. In well-trained animals occasional failures to elicit the CR were accompanied by an absence of neural responses. Nevertheless, the CS modified the behavioral unconditioned response in paired trials, implying that the CR-failures co…
Innovative control logics for a rational utilization of electric loads and air-conditioning systems in a residential building
2015
The paper focuses on the evaluation of the impact on residential buildings of innovative control logics defined for a rational utilization of the electric loads and air-conditioning systems. The control logics are implementable thanks to a Decision Support and Energy Management Systems developed by the same authors and easily installable in new and still-existing houses. The paper shows how a significant reduction of the primary energy consumption can be obtained by controlling the air-conditioning units together with the other electric loads of the house. After having explained how the control logics operate, a simulation tool is described, developed for a preliminary evaluation of their e…