Search results for "Conducta"
showing 10 items of 611 documents
Multicenter validation study for the certification of a CFTR gene scanning method using next generation sequencing technology.
2018
AbstractBackground:Many European laboratories offer molecular genetic analysis of theCFTRgene using a wide range of methods to identify mutations causative of cystic fibrosis (CF) and CFTR-related disorders (CFTR-RDs). Next-generation sequencing (NGS) strategies are widely used in diagnostic practice, and CE marking is now required for most in vitro diagnostic (IVD) tests in Europe. The aim of this multicenter study, which involved three European laboratories specialized in CF molecular analysis, was to evaluate the performance of Multiplicom’s CFTR MASTR Dx kit to obtain CE-IVD certification.Methods:A total of 164 samples, previously analyzed with well-established “reference” methods for t…
Targeting Nonsense: Optimization of 1,2,4-Oxadiazole TRIDs to Rescue CFTR Expression and Functionality in Cystic Fibrosis Cell Model Systems
2020
Cystic fibrosis (CF) patients develop a severe form of the disease when the cystic fibrosis transmembrane conductance regulator (CFTR) gene is affected by nonsense mutations. Nonsense mutations are responsible for the presence of a premature termination codon (PTC) in the mRNA, creating a lack of functional protein. In this context, translational readthrough-inducing drugs (TRIDs) represent a promising approach to correct the basic defect caused by PTCs. By using computational optimization and biological screening, we identified three new small molecules showing high readthrough activity. The activity of these compounds has been verified by evaluating CFTR expression and functionality after…
The role of extracellular calcium in bone metastasis
2016
AbstractThis review summarizes the role of extracellular calcium, as found present in the bone tissue, in the process of bone metastasis.
Efectos organizacionales y activacionales de la testosterona sobre la asunción de riesgos en conductas económicas: una revisión sistemática
2017
Resumen El objetivo de esta revision sistematica es evaluar la influencia de la testosterona circulante (efectos activacionales) y de la exposicion prenatal a ella (efectos organizacionales) sobre la asuncion de riesgos en conductas economicas, evaluando los trabajos de investigacion existentes hasta la fecha acerca de la tematica. La base bibliografica analizada se obtuvo de distintas bases de datos especializadas en el ambito de la psicologia y las neurociencias. Los resultados obtenidos concluyen en una relacion contrastada entre la testosterona circulante y la asuncion de riesgo financiero. En lo referente a la exposicion prenatal se evidencia un estado inmaduro de la investigacion sobr…
Predicting response to transdiagnostic iCBT for emotional disorders from patient and therapist involvement
2021
Background Transdiagnostic iCBT has been shown to be effective for the treatment of emotional disorders. Less is known about the optimal level of therapist and patient involvement in these interventions. Specific characteristics of Internet-delivered interventions include treatment adherence (e.g., amount of review of the materials) and guidance (e.g., amount of therapist support). Exploring the importance of these elements in treatment outcome may help to maximize the efficiency of Internet-delivered psychological interventions. Aim In this study, we aimed to analyze the relationship between patient and therapist involvement (i.e., platform usage and amount of therapist guidance) in a samp…
Motivational strategies, working alliance, and protherapeutic behaviors in batterer intervention programs: A randomized controlled trial
2020
ABSTRACT Motivational strategies are among the most promising approaches to improve the effectiveness of batterer intervention programs (BIPs). An individualized motivational plan (IMP) is one of these motivational strategies. The present study aimed to explore whether adding an IMP to a standard BIP improved the participant-facilitator working alliance and participants' protherapeutic behaviors. To this end a randomized controlled trial was conducted. One hundred fifty-three men convicted of intimate partner violence were randomly assigned to either a standard BIP (control condition, n = 79) or a standard BIP plus IMP (experimental condition, n = 74). Working alliance (i.e., general workin…
Implementation of a Positive Technology Application in Patients With Eating Disorders: A Pilot Randomized Control Trial.
2018
Background: Positive psychological interventions (PPIs) have been suggested to produce benefits in patients with eating disorders (ED) by improving well-being, which might act as a buffer of the harmful effects caused by the disorder. Best Possible Self (BPS) is a PPI which consists of writing and envisioning a future where everything has turned out in the best possible way. In this regard, positive technology (PT) can be of considerable benefit as it allows to implement specific PPIs that have already shown efficacy. Objective: This study tested the preliminary efficacy of the BPS exercise implemented through a PT application and carried out for 1 month, in improving positive functioning m…
How is the Driver's Workload Influenced by the Road Environment?
2017
Abstract This paper focuses on the study of the driver's workload while driving on a rural two-lane road with different traffic flows. The aim of the research is to examine a parameter that could be representative of the driving effort, quite sensible to the external factors that cause disturbance to the regular driving activity. To solve this problem, the authors used a specific instrumented vehicle for monitoring some physiological parameters of the driver (as the eye movements and the Galvanic Skin Resistance), referring their values to the road context. The results are very interesting and confirm that knowing the workload is useful to improve the road safety only if it is related to th…
Social support and resilience to foster prosocial behaviours during the COVID-19 pandemic confinement: an explanatory model (Apoyo social y resilienc…
2021
The containment measures taken because of the COVID-19 pandemic have had consequences on human thought and behaviour. The purpose of this study is to contrast an explanatory model of prosocial behaviours during confinement by analysing different variables involved. The study sample was made up of 946 participants (70.9% female) and had an average age of 35.25 (SD = 13.98). Participants completed a series of online questionnaires. The results show that social support is a predictor of prosocial behaviours and resilience is a mediator in this relationship;living with others is a protective factor for social support;not working during confinement is a predictor for prosocial behaviours;and bei…
L'estudi de la deshumanització i la infrahumanització en psicologia
2010
L'estudi psicosocial sobre la conducta antisocial i la crueltat dels éssers humans reconeix l'existència d'una representació deshumanitzadora de l'altre. El propòsit d'aquest article és presentar els avanços empírics en l'estudi de la infrahumanització, com a atribució diferencial de sentiments en l'endogrup i en l'exogrup. Atès que els sentiments 'per exemple, l'amor, l'esperança, el menyspreu, el ressentiment' es consideren emocions exclusivament humanes, les persones no sols atribueixen més sentiments a l'endogrup que no als exogrups, sinó que neguen a aquests últims la capacitat de vivenciar-ne. Ara oferim, en primer lloc, una descripció de les distintes perspectives que s'han utilitzat…