Search results for "Conductance"

Wide-range thermometer based on the temperature-dependent conductance of planar tunnel junctions

2000

The effect of the Fermi–Dirac distribution on the current through standard planar tunnel junctions is a suitable basis for thermometry in a wide temperature range. In particular, it extends the range spanned by Coulomb-blockade thermometers up to room temperature.

Influence of CO in the structural and electrical properties of Pt nanocontacts: comparison with H2 molecule addition.

2009

Density-functional theory is used to determine the atomic structure and the zero-bias conductance of Pt nanocontacts upon CO addition. Three stable atomic configurations of the nanocontacts, in conjunction with a statistical analysis of their electrical response, are enough to explain the main features of the experimental conductance histograms. Remarkably, the role of nonlocal effects when approaching the exchange-correlation potential within density-functional theory turns out to be crucial for CO molecular-based systems. Finally, a comparison with H(2) molecule addition on Pt nanocontacts is presented.

2019

Abstract This article contains intensity and aversiveness ratings of electrical stimuli and data on electrodermal activity (skin conductance level and skin conductance response) during an implicit conditioning procedure. Further, answers from a questionnaire on contingency awareness are provided. The experiment consisted of three phases. In the acquisition, two types of visual stimuli (CS+ and CS-) were coupled to weakly and moderately painful electrical stimuli presented to the participants’ (N = 48) dominant hand. In the test phase, after both CS+ and CS- only the weakly painful electrical stimuli were presented. In the contingency test phase, no more electrical stimuli were presented and…

A versatile model of steady state O2 supply to tissue. Application to skeletal muscle

1990

A model of combined convective and diffusive O2 transport to tissue is suggested which allows for the calculation of PO2 distributions in a cuboid tissue region with arbitrary microvascular geometries and blood flows. Carrier-facilitated O2 diffusion in the erythrocytes and in the tissue and red blood cell reaction kinetics are considered. The model is based on analytical descriptions of the PO2 fields of single erythrocytes surrounded by carrier-free layers in an infinite three-dimensional space containing an O2 carrier such as myoglobin. These PO2 fields are overlaid to obtain a solution of the differential equation of diffusion in respiring tissue. The model has been applied to a situati…

1996

The uses of atomic force microscopy, scanning tunneling microscopy, electron spectroscopic imaging, electron energy loss spectroscopy and low voltage, high resolution scanning electron microscopy in polymer research are reviewed

Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives.

2015

Abstract Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological approach to treat these diseases is to promote the translational readthrough of premature stop codons by small molecules aiming to restore the full-length protein. The compound PTC124 (Ataluren) was reported to promote the readthrough of the premature UGA stop codon, although its activity was questioned. The potential interaction of PTC124 with mutated mRNA was recently suggested by molecular dynamics (MD) studies highlighting the importanc…

Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents.

2020

In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed by a mixture of two polyhydrohydroxyethtylaspartamide copolymers containing a loading of Ivacaftor of 15.5 % w/w were produced. These Nanoparticles were incorporated into microparticles to obtain NiM that were characterized in terms of size and size distribution, interaction with CF-AM by rheological and turbidimetric studies as well as by aerodynamic diameter measurements. Finally the activity of Ivacaftor into these NiM was evaluated by in vitr…

HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF

2019

The present invention relates to heterocyclic nitrogen compounds, use thereof as a medicament and pharmaceutical compositions thereof. Furthermore, the invention provides combinations of compounds of general formula (I) with therapeutic agents, such as correctors, potentiators and amplifiers of dysfunctional proteins.

Impaired Transporter Associated with Antigen Processing (TAP) Function Attributable to a Single Amino Acid Alteration in the Peptide TAP Subunit TAP1

2003

Abstract The heterodimeric peptide transporter TAP belongs to the ABC transporter family. Sequence comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance regulator and the functional properties of selective amino acids in these ABC transporters postulated that the glutamic acid at position 263 and the phenylalanine at position 265 of the TAP1 subunit could affect peptide transporter function. To define the role of both amino acids, TAP1 mutants containing a deletion or a substitution to alanine at position 263 or 265 were generated and stably expressed in murine and human TAP1−/− cells. The different TAP1 mutants were characterized in terms of expression and funct…

Characterization of Emergence of the Coulomb Blockade in a Pearl-Like DNA-AuNP Assembly

2023

Due to its superior self-assembly properties and vast functionalization pos-sibilities DNA has long been one of the most promising candidates forfabrication of nanoscale electrical components using molecular buildingblocks. There exist already many demonstrations on optical devices based onorganizing metallic nanoparticles (NP) via DNA self-assembly, but despite thepromises only few DNA based electrical devices or studies have been realizedso far. Here we study the gold NP conjugated and metallized DNA TX-tile-structure, which we recently showed to exhibit the room temperature Coulombblockade, the pre-requisition for a single electron transistor. The properties ofthe obtained Coulomb blocka…