Search results for "Confinement"
showing 10 items of 213 documents
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
2021
Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we show that nuclear envelope ruptures induce DNA damage that promotes senescence in non-transformed cells and induces an invasive phenotype in human breast cancer cells. We find that the endoplasmic reticulum (ER)-associated exonuclease TREX1 translocates into the nucleus after nuclear envelope rupture and is required to induce DNA damage. Inside the mammary duct, cellular crowding leads to nuclear envelope ruptures that generate TREX1-dependent DNA damage, thereby driving the …
COVID-19, Gender Housework Division and Municipality Size in Spain
2022
The COVID-19 health crisis brought with it an increase in the workload on family members due to the restriction of services and the suspension of formal and informal care networks. Numerous studies have analyzed how home confinement have affected different gender gaps, including the gender gap related to chores within the home. This research aims to contribute to the existing literature from the perspective of gender geography by introducing the variable municipality size in the analyses. Our research in the case of Spain shows the COVID-19 health crisis to have had a significant impact on gender gaps, albeit to varying degrees. Women, especially those living in small municipalities, experi…
A Theoretical Model to Evaluate the Compressive Behaviour of RС Jacketed Columns
2016
Reinforced concrete (RC) jacketing is becoming increasingly common among the different retrofit techniques for poor RC members, due to its economical and practical advantages. Experimental investigations in the literature have shown that the actual axial capacity of RC jacketed members can be substantially lower than that analytically evaluated by adapting the most common theoretical models for confined concrete. This fact can be explained by taking into account the presence of tensile stresses developing in the concrete, due to a mutual interaction between the inner core and the external jacket. This phenomenon is relevant especially in members where the concrete properties of the jacket a…
Flexural behavior of R.C. columns externally wrapped with FRP sheets
2012
In the present paper the compressive and flexural behavior of R.C. columns externally wrapped with FRP layers is examined. The investigation refers to a short compressed R.C. member having circular transverse cross-section and reinforced with longitudinal bars and transverse hoops or spirals. A first phase of the investigation was addressed to describing the constitutive laws of constituent materials (confined concrete core, steel bars in compression and in tension, FRP in tension). The second phase of the research was addressed to deriving the compressive and flexural responses in terms of load-axial shortening curves and momentaxial force interaction domain, to be compared with experiment…
Compressive response of concrete columns under service conditions strengthened by confining devices: from the local to the global behavior.
Il rinforzo di colonne in calcestruzzo armato tramite materiali polimerici fibrorinforzati (FRP) o tramite incamiciature in acciaio conferisce agli elementi strutturali degli edifici esistenti un elevato incremento di capacità portante e deformativa grazie alle proprietà dei materiali che svolgono la funzione di confinamento. Conoscere adeguatamente le proprietà meccaniche degli elementi in calcestruzzo confinato risulta di fondamentale importanza nell’ambito di un progetto di sistemi di rinforzo strutturale. Tuttavia, le normative attualmente vigenti non forniscono prescrizioni su come tenere in considerazione la presenza dei carichi di esercizio sugli elementi strutturali al momento dell’…
A Handy Stress-Strain Law for FRP Confined Concrete
2006
Performance Assessment of Basalt FRCM for the Confinement of Clay Brick Masonry Cylinders
2021
Fibre Reinforced Cementitious Matrix (FRCM) composites have been proved to be a suitable strengthening material for masonry structures in the last years. Moreover, basalt fibres are increasingly used as reinforcement of composites as a more sustainable alternative to glass fibres. The goal of this work is to investigate the effectiveness of basalt FRCM to confine masonry circular columns. A total of eighteen clay brick masonry cylinders were tested in compression. The specimens were cored from two different masonry assemblies and wrapped with one or two layers of BFRCM composite. The stress-strain curves and the gains of strength and strain capacity of confined cylinders compared to the con…
Numerical analysis of the effects of PBO-FRCM confinement on RC columns
2018
This paper presents a finite element (FE) analysis on the behavior of reinforced concrete (RC) squared and rectangular columns strengthened by PBO-FRCM, under axial force and bending moment. The modeling technique adopted for the compressive behavior of confined concrete is previously validated developing FE models for specimens of plain concrete wrapped by PBO-FRCM and comparing the numerical results with those obtained by experimental tests on squared and rectangular confined columns. Then, the model of the RC element is developed reproducing the load condition of columns in a MRF loaded by horizontal forces with constant axial load applied to the pillar during the analysis. The numerical…