Search results for "Context"
showing 10 items of 6304 documents
ABCL-346: Overall Survival with Tafasitamab + Lenalidomide (LEN) vs Routinely Administered Therapies for ASCT-Ineligible Relapsed or Refractory (R/R)…
2021
Context Tafasitamab+LEN, a chemotherapy-free, novel treatment for R/R DLBCL, demonstrated efficacy in ASCT-ineligible patients in the single-arm Phase II L-MIND study (NCT02399085). Objective To compare outcomes in patients treated with tafasitamab+LEN in the L-MIND study with matched patient populations treated with commonly administered NCCN-/ESMO-recommended therapies for non-transplant-eligible patients with R/R DLBCL in routine clinical practice. Design RE-MIND2 (NCT04150328) is an observational, retrospective cohort study. The L-MIND tafasitamab+LEN cohort was matched with RE-MIND2 patients using estimated propensity score-based 1:1 nearest neighbor matching balanced for nine patient …
History of education and the struggle for intellectual liberation in post-Soviet Baltic space after the fall of the Berlin Wall
2014
This study on a “new” history of education is written from the perspective of a participant in the process of discarding Soviet intellectual and physical boundaries. The fall of the Berlin Wall has, over the past two decades, become a continuous process in post-Soviet societies, when the now liberated historians of education were faced with a new challenge, namely integration into the newly opened world. The only allowed theory, Marxism-Leninism, reduced historians of education to superficial methodology and its trivialisation. However, the collapse of the USSR did not immediately result in new theoretical concepts, because historians were busy discovering fresh facts in newly accessed arch…
Cropland and grassland management
2014
According to the latest National Inventory, the Italian agricultural sector is a source of GHGs with 34.5 Mt of CO2 eq in 2009, corresponding to 7 % of the total emissions (excluding LULUCF). In particular, more than half (19.1 Mt of CO2 eq) are N2O emissions from soils. Although the national methodology is in accordance with Tier 1 and 2 approaches proposed by the IPCC (2006), still empirical emission factors are used to assess the emission from fertilizer (e.g. 0.0125 kg N2O–N kg−1 N from synthetic fertilizers). Disaggregated data at sub-national level, including models and inventory measurement systems required by higher order methods (i.e. Tier 3), are not available in Italy so far and …
Implementation of Content and Language Integrated Learning at Schools in Latvia
2017
The European Union supports multilingualism and promotes the learning of foreign languages since their knowledge enhances understanding among peoples and increases employability. To increase the efficiency and effectiveness of foreign language education in schools, Content and Language Integrated Learning (CLIL) has been promoted in Europe; this has influenced ways in which Latvia nowadays approaches bilingual education. A qualitative case study was undertaken to explore the implementation of CLIL at schools in Latvia, CLIL being seen as an element of bilingual education. This article outlines the development of CLIL in Latvia, which is largely embedded in national level policies which have…
A discursive analysis of oppositional interpretations of the agro-food system: A case study of Latvia
2015
Abstract This article critically reflects on the literature that addresses the complexity of food systems, which is often caught in application of simplistic binary oppositions of local vs. global, short vs. long, sustainable vs. intensive, etc. It then goes on to show, through a case study analysis of food-system discourses in Latvia how the binary oppositions surrounding with food systems, are actually mobilised in a specific national context. Agro-food systems are often explained through binary opposing knowledge systems that, depending on the theoretical affiliation of the author, might be called frames, narratives or discourses. These powerful instruments are used to explain, and often…
Cluster-based active learning for compact image classification
2010
In this paper, we consider active sampling to label pixels grouped with hierarchical clustering. The objective of the method is to match the data relationships discovered by the clustering algorithm with the user's desired class semantics. The first is represented as a complete tree to be pruned and the second is iteratively provided by the user. The active learning algorithm proposed searches the pruning of the tree that best matches the labels of the sampled points. By choosing the part of the tree to sample from according to current pruning's uncertainty, sampling is focused on most uncertain clusters. This way, large clusters for which the class membership is already fixed are no longer…
Silver Oxide Mediated Monotosylation of Poly(ethylene glycol) (PEG): Heterobifunctional PEG via Polymer Desymmetrization
2017
Heterobifunctional poly(ethylene glycol)s (PEGs) are key structures for bioconjugation in the context of the “PEGylation” strategy to enhance blood circulation times of, for example, peptide drugs or “stealth” liposomes. The formation of heterobifunctional PEGs from symmetric PEG diols is challenging because of limited yields of the targeted monofunctional product and difficulties associated with separation steps. On the basis of a detailed comparison of reaction conditions, we have investigated a “polymer desymmetrization” strategy to maximize the yields of monofunctional PEG tosylate. The tosylation reaction in the presence of the heterogeneous catalyst silver oxide and potassium iodide i…
Enzymatic biodiesel: Challenges and opportunities
2014
The chemical-catalyzed transesterification of vegetable oils to biodiesel has been industrially adopted due to its high conversion rates and low production time. However, this process suffers from several inherent drawbacks related to energy-intensive and environmentally unfriendly processing steps such as catalyst and product recovery, and waste water treatment. This has led to the development of the immobilized enzyme catalyzed process for biodiesel production which is characterized by certain environmental and economical advantages over the conventional chemical method. These include room-temperature reaction conditions, elimination of treatment costs associated with recovery of chemical…
PET: Theoretical Background and Practical Aspects
2012
Positron emission tomography (PET) is a nuclear medicine imaging tool utilized for investigation of physiological processes in vivo. PET uses the decay characteristics of positron-emitting radionuclides which are produced in a cyclotron and then used to label compounds involved in physiological processes. Usually, the labeled compound—the tracer—is administered intravenously and distributed in the tissue. The radionuclide decays and the emitted photons are detected by the PET scanner. PET then offers the possibility to compute three-dimensional images of the biodistribution and kinetics of the regional radioactivity concentration. There are several options to analyze reconstructed PET image…
Minor changes in the macrocyclic ligands but major consequences on the efficiency of gold nanoparticles designed for radiosensitization
2016
International audience; Many studies have been devoted to adapting the design of gold nanoparticles to efficiently exploit their promising capability to enhance the effects of radiotherapy. In particular, the addition of magnetic resonance imaging modality constitutes an attractive strategy for enhancing the selectivity of radiotherapy since it allows the determination of the most suited delay between the injection of nanoparticles and irradiation. This requires the functionalization of the gold core by an organic shell composed of thiolated gadolinium chelates. The risk of nephrogenic systemic fibrosis induced by the release of gadolinium ions should encourage the use of macrocyclic chelat…