Search results for "Continuation"
showing 10 items of 276 documents
Patient perspectives in the management of asthma: improving patient outcomes through critical selection of treatment options
2010
Asthma is a chronic inflammatory disorder of the airways that requires long-term treatment, the goal of which is to control clinical symptoms for extended periods with the least possible amount of drugs. International guidelines recommend the addition of an inhaled long-acting beta2-agonist (LABA) to a low- to medium-dose inhaled corticosteroid (ICS) when low doses of ICS fail to control asthma symptoms. The fixed combined administration of ICS/LABA improves patient compliance, reducing the risk of therapy discontinuation. The relative deposition pattern of the inhaled drug to the target site is the result of a complex interaction between the device used, the aerosol formulation and the pat…
Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients
2008
Background Hereditary angioedema (HAE) due to C1 inhibitor deficiency is clinically characterized by relapsing skin swellings, abdominal pain attacks, and life-threatening upper airway obstruction. Treatment with androgens prevents attacks for those with this condition. Objective To examine the benefits and risks of long-term treatment with danazol. Methods Data were generated retrospectively from 118 German and Danish patients who had HAE due to C1 inhibitor deficiency and were treated with danazol from 2 months to 30 years. The frequency and severity of acute attacks were registered before and during danazol treatment, and adverse effects to the treatment were noted. Data were collected b…
Duality of moduli in regular toroidal metric spaces
2020
We generalize a result of Freedman and He [4, Theorem 2.5], concerning the duality of moduli and capacities in solid tori, to sufficiently regular metric spaces. This is a continuation of the work of the author and Rajala [12] on the corresponding duality in condensers. peerReviewed
Physician Perspectives on Unresolved Issues in the Management of Ulcerative Colitis: The UC Horizons Project.
2015
BACKGROUND There is still uncertainty about what constitutes the best therapeutic practice in ulcerative colitis (UC). OBJECTIVE The purpose of the "UC Horizons Project" was to raise a series of questions regarding the management of UC to provide responses based on the best scientific evidence available. METHODS The 11 members of the scientific committee prepared draft answers to the 10 questions from available evidence after a literature search. A total of 48 Spanish gastroenterology specialists nationwide participated in the project. The national meeting discussed the 10 issues in working groups and reached consensus regarding the recommendations by anonymous, interactive vote following t…
Early virologic response with pegylated interferons
2004
Abstract Recently, 12-week evaluation of viral response has been recommended as a means of reducing antiviral treatment morbidity and costs. The development of early stopping rules relies on an important assumption: rules must minimise discontinuation of treatment in patients who might ultimately respond after completion of the full course of therapy. Minimising loss of potential responders is the most important clinical goal in defining an early stopping rule because it provides the most sustained virological responders. This definition of the rule relies on maximising the negative predictive value. Conversely, rules that select patients based on optimising the positive predictive value pr…
Realizacja zasady równości w zakresie dostępu do dóbr kultury narodowej
2021
Celem niniejszego tekstu jest udowodnienie, że art. 6 ust. 1 jest przepisem wskazującym na szczegółową dziedzinę, w której zastosowanie ma zasada równości wyrażona w treści art. 32 i 33 Konstytucji RP. Aby tego dowieźć, wyjaśniono, jak równość odnosi się do zakresu podmiotów uprawnionych do tego, aby im upowszechniać i udostępniać dobra kultury narodowej. Udowodnione zostało również, że odniesienie równości do upowszechniania i udostępniania dóbr kultury narodowej wymaga zastosowania uprzywilejowania wyrównawczego wynikającego z przesłanek faktycznych, a nie tylko prawnych. Przy okazji tak zakrojonych badań wykazane zostało również, że art. 6 ust. 1 jest także konkretyzacją art. 5 in fine o…
L'admission ou le rejet d'une créance dans une procédure collective n'a pas autorité de la chose jugée dans la deuxième procédure collective ouverte …
2004
International audience; (Com. 3 déc. 2003, Mme Baptiste c/ Dechriste ès qualités, pourvoi n° Z 02-14.474, arrêt n° 1712 FS-P+B+I, D. 2004, AJ p. 62 et les obs.)
Anakinra drug retention rate and predictive factors of long-term response in systemic juvenile idiopathic arthritis and adult onset still disease
2019
Background and Objective: Only a few studies have reported long-term efficacy of interleukin (IL)-1 inhibition in systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still disease (AOSD). Herein we report on the effectiveness of anakinra (ANA), expressed in terms of drug retention rate (DRR), and evaluate the predictive factors of drug survival in a cohort of patients with sJIA and AOSD. Patients and Methods: This is a multicenter study reviewing retrospectively the medical records from 61 patients with sJIA and 76 with AOSD, all treated with ANA in 25 Italian tertiary referral centers. Results: The cumulative retention rate of ANA at 12-, 24-, 48-, and 60-month of follow-up was 7…
Analytic continuation and numerical evaluation of the kite integral and the equal mass sunrise integral
2017
We study the analytic continuation of Feynman integrals from the kite family, expressed in terms of elliptic generalisations of (multiple) polylogarithms. Expressed in this way, the Feynman integrals are functions of two periods of an elliptic curve. We show that all what is required is just the analytic continuation of these two periods. We present an explicit formula for the two periods for all values of $t \in {\mathbb R}$. Furthermore, the nome $q$ of the elliptic curve satisfies over the complete range in $t$ the inequality $|q|\le 1$, where $|q|=1$ is attained only at the singular points $t\in\{m^2,9m^2,\infty\}$. This ensures the convergence of the $q$-series expansion of the $\mathr…
A randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus
2021
BACKGROUND Oral lichen planus (OLP) is a common, frequently symptomatic, immune-mediated disease. Various treatments have been used for symptomatic OLP, including corticosteroids and immunosuppressants administered topically or systemically. The aim of this study was to compare the effectiveness of topical dexamethasone vs. topical cyclosporine in treatment of symptomatic OLP. MATERIAL AND METHODS Thirty-two patients with biopsy-proven symptomatic OLP were randomly assigned to two therapeutic groups: dexamethasone 2mg/5ml or cyclosporine 100mg/ml, both administered topically in a swish and spit method three times a day for 4 weeks. The patients were followed up for a total of 6 months. Asse…