Search results for "Continuation"

Counterexamples for unique continuation

1988

Analytic curves in power series rings

1990

Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications

2011

Thirty years after the discovery of HIV infection, there are numerous antiretroviral drugs that control the disease when administered in a potent combination referred to as Highly Active Antiretroviral Therapy (HAART). This therapy reduces the viral load and improves immune system reconstitution, leading to a significant reduction of HIV-related morbidity and mortality. However, HAART does not completely eliminate HIV, so treatment must continue throughout the patient's life. Prolonged use of HAART has been related to long-term adverse events that can compromise patient health. These deleterious effects have been reported for the majority of antiretroviral drugs and are the most common caus…

Arterial hypertension in cancer: The elephant in the room

2019

The great therapeutical success achieved by oncology is counterbalanced by growing evidences of cardiovascular (CV) toxicity due to many antineoplastic treatments. Cardiac adverse events may cause premature discontinuation of effective oncologic treatments or occur as late events undermining the oncologic success. Arterial hypertension is both the most common comorbidity in cancer patients and a frequent adverse effect of anticancer therapies. A pre-existing hypertension is known to increase the risk of other cardiac adverse events due to oncologic treatments, in particular heart failure. Moreover, as a strict association between cancer and CV diseases has emerged over the recent years, var…

Internal Simulation of an Agent’s Intentions

2013

We present the Associative Self-Organizing Map (A-SOM) and propose that it could be used to predict an agent’s intentions by internally simulating the behaviour likely to follow initial movements. The A-SOM is a neural network that develops a representation of its input space without supervision, while simultaneously learning to associate its activity with an arbitrary number of additional (possibly delayed) inputs. We argue that the A-SOM would be suitable for the prediction of the likely continuation of the perceived behaviour of an agent by learning to associate activity patterns over time, and thus a way to read its intentions.

A Dirichlet problem for the Laplace operator in a domain with a small hole close to the boundary

2016

We study the Dirichlet problem in a domain with a small hole close to the boundary. To do so, for each pair $\boldsymbol\varepsilon = (\varepsilon_1, \varepsilon_2 )$ of positive parameters, we consider a perforated domain $\Omega_{\boldsymbol\varepsilon}$ obtained by making a small hole of size $\varepsilon_1 \varepsilon_2 $ in an open regular subset $\Omega$ of $\mathbb{R}^n$ at distance $\varepsilon_1$ from the boundary $\partial\Omega$. As $\varepsilon_1 \to 0$, the perforation shrinks to a point and, at the same time, approaches the boundary. When $\boldsymbol\varepsilon \to (0,0)$, the size of the hole shrinks at a faster rate than its approach to the boundary. We denote by $u_{\bolds…

Multiplicity results for systems of asymptotically linear second order equations

2002

Abstract We prove the existence and multiplicity of solutions, with prescribed nodal properties, for a BVP associated with a system of asymptotically linear second order equations. The applicability of an abstract continuation theorem is ensured by upper and lower bounds on the number of zeros of each component of a solution.

Multiplicity results for asymptotically linear equations, using the rotation number approach

2007

By using a topological approach and the relation between rotation numbers and weighted eigenvalues, we give some multiplicity results for the boundary value problem u′′ + f(t, u) = 0, u(0) = u(T) = 0, under suitable assumptions on f(t, x)/x at zero and infinity. Solutions are characterized by their nodal properties.

Initiation and duration of dual antiplatelet therapy after inpatient percutaneous coronary intervention with stent implantation in Germany: An electr…

2017

Abstract Background Studies assessing the routine outpatient dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in Germany are scarce. The aim of this study was (i) to investigate the initiation and duration of DAPT after inpatient PCI with stent implantation in Germany, and (ii) to identify factors associated with DAPT discontinuation during the recommended treatment period. Methods This retrospective cohort study was based on data from a large German electronic healthcare database of the years 2004 to 2009. The study population comprised four groups of patients with acute coronary syndrome (ACS) or stable angina pectoris undergoing inpatient PCI with either ba…

Predictors of early discontinuation of dapagliflozin versus other glucose-lowering medications: a retrospective multicenter real-world study

2020

Background and aims: In routine clinical practice, early discontinuation of newly initiated glucose-lowering medications (GLM) is relatively common. We herein evaluated if the clinical characteristics associated with early discontinuation of dapagliflozin were different from those associated with early discontinuation of other GLM. Methods: The DARWIN-T2D was a multicenter retrospective study conducted at diabetes specialist outpatient clinics in Italy. We included 2484 patients who were initiated on dapagliflozin in 2015–2016 and 14,801 patients who were initiated on other GLM (DPP-4 inhibitors, GLP-1 receptor agonists, or gliclazide) in the same period. After excluding patients who had no…