Search results for "Controlled Clinical Trials as Topic"

showing 9 items of 19 documents

The effect of probiotics as a treatment for constipation in elderly people: A systematic review.

2016

Abstract Purpose Treating constipation in elderly people remains a challenge; the administration of probiotics may be a valid therapy for this problem as an alternative to traditional drug-based treatments. The objective of this systematic review was to evaluate the efficiency of probiotics in treating constipation in elderly people. Methods Articles related to this topic and published, without any time limitations, in the Medline, Embase, Scopus, Lilacs, or Cochrane databases were systematically reviewed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The primary search terms were ‘constipation’ and ‘probiotics’. The main inclusion crite…

MaleAgingmedicine.medical_specialtyHealth (social science)ConstipationMEDLINEAlternative medicinePlaceboGastroenterologylaw.invention03 medical and health sciencesProbiotic0302 clinical medicinelawInternal medicinemedicineHumans030212 general & internal medicineIntensive care medicineAgedAged 80 and overbusiness.industryClinical study designProbioticsSystematic review030211 gastroenterology & hepatologyObservational studyFemaleControlled Clinical Trials as TopicGeriatrics and Gerontologymedicine.symptombusinessGerontologyConstipationArchives of gerontology and geriatrics
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Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multicenter, three-armed randomized…

2017

Depression is one of the most common mental disorders and will become one of the leading causes of disability in the world. Internet-based CBT programs for depression have been classified as well established following the American Psychological Association criteria for empirically supported treatments. The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program Smiling is fun with (LITG) and without psychotherapist support (TSG) compared to usual care. The perspective used in our analysis is societal. A sample of 296 depressed patients (mean age of 43.04 years; 76% female; BDI-II mean score = 22.37) from primary care services in four Sp…

MaleSpanish PeopleEconomicsPsychological interventionSocial SciencesSeverity of Illness Indexlaw.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Learning and Memory0302 clinical medicineHispanoamericanosEthnicitiesPsychologyAnálisis de intención de tratarlcsh:Sciencemediana edadancianoDepressionAntidepressantsadulto:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]Humanosadulto joven:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic::Intention to Treat Analysis [Medical Subject Headings]Psicoterapia:Information Science::Information Science::Computing Methodologies::Computer Systems::Computer Communication Networks::Internet [Medical Subject Headings]medicine.medical_specialtyEvidence-based practiceGrupos control03 medical and health sciences:Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Cost-Benefit Analysis [Medical Subject Headings]Drug TherapySeverity of illnessHumans:Persons::Persons::Age Groups::Adult [Medical Subject Headings]psicoterapiaAgedPharmacologyDepressive DisorderDepressive Disorder MajorInternetPrimary Health CareMood Disorderslcsh:RBiology and Life SciencesSonrisa030227 psychiatryHealth CareAnálisis costo-beneficio:Check Tags::Female [Medical Subject Headings]Economic evaluationlcsh:QPopulation GroupingsNeuroscienceGerontologyFinancial ManagementCost effectivenessCost-Benefit Analysishumanosadolescentelcsh:MedicineTrastorno depresivoRandomized controlled triallawDepresiónMedicine and Health Sciences030212 general & internal medicineMultidisciplinaryAdultoPharmaceuticsresultado del tratamientoFemeninoDrugsCost-effectiveness analysisMiddle AgedTelemedicineTreatment OutcomeSociedades científicasFemale:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Communication::Nonverbal Communication::Facial Expression::Smiling [Medical Subject Headings]Estudios de seguimiento:Persons::Persons::Population Groups::Ethnic Groups::Hispanic Americans [Medical Subject Headings]telemedicinaResearch ArticleAdultAdolescent:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control Groups [Medical Subject Headings]:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychotherapy [Medical Subject Headings]Cost-Effectiveness AnalysisMEDLINEYoung Adulttrastorno depresivoAtención primaria de saludMental Health and PsychiatryIndirect CostsmedicineLearningíndice de gravedad de la enfermedadPrimary Care:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder [Medical Subject Headings]:Health Care::Health Care Economics and Organizations::Organizations::Societies::Societies Scientific [Medical Subject Headings]Cognitive Behavioral Therapybusiness.industryCognitive Psychology:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Follow-Up Studies [Medical Subject Headings]Economic AnalysisPsychotherapyPeople and PlacesPhysical therapyCognitive Science:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings]businessFinance
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Efficacy of a blended low-intensity internet-delivered psychological programme in patients with multimorbidity in primary care: study protocol for a …

2019

BackgroundThe World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, health care systems are mainly designed for the management of individual diseases. Given the difficulty in delivering face-to-face psychological treatments, alternative models of treatment delivery have been proposed, emphasizing the role of technologies such as the Internet. The aim of this study is to assess the efficacy in Primary Care (PC) of a blended low-intensity psychological intervention applied using information and communication technologies (ICTs) for the treatment of …

MaleTecnología de la informaciónhumanosPsychological interventiondepresiónEnsayo clínico controlado aleatoriolaw.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]dolor lumbarStudy Protocol0302 clinical medicineRandomized controlled triallawlcsh:PsychiatryDepresiónHealth careGlobal healthMedicine030212 general & internal medicineRandomized Controlled Trials as Topic:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]Depressionensayos clínicos controlados aleatorizados como asuntoMultimorbilidadadultoPrimary careLow back pain:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]Psychiatry and Mental healthdiabetes mellitus:Information Science::Information Science::Computing Methodologies::Computer Systems::Computer Communication Networks::Internet [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Pain::Back Pain::Low Back Pain [Medical Subject Headings]Femalemedicine.symptomAdultmedicine.medical_specialtyenfermedad crónicalcsh:RC435-571:Check Tags::Male [Medical Subject Headings]03 medical and health sciencesInformation and communication technologies (ICTs)Atención primaria de saludIntervention (counseling)Humans:Persons::Persons::Age Groups::Adult [Medical Subject Headings]:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]InternetPrimary Health Carebusiness.industry:Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings]Multimorbidity:Health Care::Health Care Facilities Manpower and Services::Health Personnel::Physicians::Physicians Primary Care [Medical Subject Headings]medicine.diseaseComorbidity030227 psychiatryClinical trial:Check Tags::Female [Medical Subject Headings]Diabetes Mellitus Type 2SpainChronic DiseasePhysical therapyRandomized controlled trial (RCT)business:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings]Low Back PainBMC psychiatry
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Non small cell lung cancer patients with ECOG PS2: unsolved questions and lessons from clinical trials

2005

In the last two decades the results of medical treatment of advanced non-small cell lung cancer (NSCLC) have constantly improved even if they are still far from being considered satisfactory. Today systemic cisplatin-based chemotherapy (CT) is able to increase survival and improve cancer-related symptoms in patients with advanced ‘wet’ stage III and metastatic stage IV NSCLC, but it not clear if the benefits of CT also apply to patients with poor performance status (PS) [1, 2]. PS is the most powerful independent prognostic factor in advanced NSCLC since it is a reliable measure of functional independence, ability to perform daily activities and work, and a strong predictor of survival and …

Oncologymedicine.medical_specialtyLung Neoplasmsbusiness.industryDrugs Investigationallung cancer performance status 2 chemotherapy best supportive careHematologymedicine.diseaseClinical trialRegimenOncologyQuality of lifeCarcinoma Non-Small-Cell LungInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansControlled Clinical Trials as TopicStage (cooking)Lung cancerbusinessAdverse effectSurvival rateSurvival analysisNeoplasm StagingAnnals of Oncology
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Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, a…

2008

Background We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004. Objective To ensure that this consensus remains current. Methods In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted. Results This consensus algorithm …

Pulmonary and Respiratory MedicineConsensus algorithmmedicine.medical_specialtyCanadaC1 inhibitor deficiencyConsensus Development Conferences as TopicInternational CooperationImmunologyMEDLINEEcallantidemedicineImmunology and AllergyHumansHungarybusiness.industryAngioedemas HereditaryState of the art reviewEvidence-based medicinemedicine.diseaseBlood DisorderFamily medicineHereditary angioedemaControlled Clinical Trials as TopicbusinessAlgorithmsmedicine.drugAnnals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology
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Aspirin use and breast cancer risk: a meta-analysis and meta-regression of observational studies from 2001 to 2005

2007

Purpose To examine the recent epidemiological studies on aspirin use and breast cancer risk published from 2001 to 2005 within a meta-analysis, to investigate reasons for heterogeneity between the individual studies and to analyse a dose-response-relationship considering frequency and duration of use. Methods We systematically searched for cohort-studies and case-control-studies from 2001–2005, which evaluated the association between aspirin and breast cancer risk. We calculated a pooled estimate for the relative risk (RR) and investigated reasons for heterogeneity between the individual studies and analysed a dose-response-relationship using random effects mixed models. Results We identifi…

RiskOncologymedicine.medical_specialtyEpidemiologyBreast NeoplasmsDrug Administration ScheduleBreast cancerInternal medicineEpidemiologymedicineHumansPharmacology (medical)Meta-regressionAspirinModels StatisticalAspirinDose-Response Relationship Drugbusiness.industryAnti-Inflammatory Agents Non-SteroidalReproducibility of Resultsmedicine.diseaseRandom effects modelSurgeryMeta-analysisRelative riskRegression AnalysisFemaleObservational studyControlled Clinical Trials as Topicbusinessmedicine.drugPharmacoepidemiology and Drug Safety
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Effect of a common exercise programme with an individualised progression criterion based on the measurement of neuromuscular capacity versus current …

2021

IntroductionHigh-load resistance training has shown positive effects in pain and function in lower limb tendinopathies. However, some authors suggest that current exercise programmes produce an increase in tolerance to load and exercise in general but without fixing some existing issues in tendinopathy. This may indicate the need to include training aspects not currently taken into account in the current programmes. The main objective of this study will be to compare the effect of a common exercise protocol for the three predominant lower limb tendinopathies (Achilles, patellar and gluteal), based on an individualised control of the dose and training of specific aspects of the neuromuscular…

Sports medicinehipFerides i lesions Tractamentknee:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Quality of lifeInformed consent:Anatomy::Body Regions::Extremities::Lower Extremity [Medical Subject Headings]:Anatomy::Musculoskeletal System::Tendons::Achilles Tendon [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Rehabilitation::Exercise Therapy [Medical Subject Headings]1506Randomized Controlled Trials as Topic:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]foot & ankleMedicina física y rehabilitaciónRrehabilitation medicineGeneral MedicineExercise TherapyTreatment OutcomeLower Extremity:Anthropology Education Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings]MedicineRodillamedicine.medical_specialtyBest practiceCaderaRehabilitation MedicineIntervention (counseling)medicineHumans1727:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]Protocol (science)sports medicineFootbusiness.industryPieMedicina deportivamedicine.diseaseClinical trialTendinopathy:Diseases::Musculoskeletal Diseases::Muscular Diseases::Tendinopathy [Medical Subject Headings]Physical therapyQuality of LifeTobilloAnkleTendinopathyTendinitisbusiness
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A central nervous system-focused treatment approach for people with frozen shoulder: protocol for a randomized clinical trial

2019

Background: Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist. The aim of this study will be to compare the effectiveness of a central nervous system (CNS)-directed treatment program versus a standard medical and physical therapy care program on outcomes in participants with FS. Methods/design: The study is a two-group, randomized clinical trial with blinding of participants and assessors. Participants will be recruited via referrals fr…

Time FactorsJoint mobilizationDolor de hombro:Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings]Shoulder painShoulder adhesive capsulitisPsychological interventionMedicine (miscellaneous)law.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Disability EvaluationStudy ProtocolDiscrimination Psychological0302 clinical medicineRandomized controlled trialFeedback Sensorylaw:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities [Medical Subject Headings]:Diseases::Musculoskeletal Diseases::Joint Diseases::Bursitis [Medical Subject Headings]Pharmacology (medical)030212 general & internal medicineRange of Motion ArticularPhysiotherapyFisioterapiaRandomized Controlled Trials as Topic:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]lcsh:R5-920Shoulder JointFrozen shoulder:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Disability Evaluation [Medical Subject Headings]Treatment OutcomeCohortlcsh:Medicine (General):Anatomy::Musculoskeletal System::Skeleton::Joints::Shoulder Joint [Medical Subject Headings]medicine.medical_specialtyBlindingSensationContext (language use)03 medical and health sciencesBursitismedicineHumansPhysical Therapy Modalities:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System [Medical Subject Headings]business.industry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Range of Motion Articular [Medical Subject Headings]Recovery of FunctionCapsulitismedicine.disease:Phenomena and Processes::Biological Phenomena::Recovery of Function [Medical Subject Headings]Sistema nervioso central:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Sensation [Medical Subject Headings]SpainCentral nervous systemOrthopedic surgeryShoulder adhesivePhysical therapy:Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis::Feedback Physiological::Feedback Sensory [Medical Subject Headings]business030217 neurology & neurosurgery
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Suspected Nonceliac Gluten Sensitivity Confirmed in Few Patients After Gluten Challenge in Double-Blind, Placebo-Controlled Trials

2017

A double-blind, placebo-controlled, gluten challenge has been proposed to confirm a diagnosis of non-celiac gluten sensitivity (NCGS) in patients without celiac disease who respond to a gluten-free diet. To determine the accuracy of this approach, we analyzed data from 10 double-blind, placebo-controlled, gluten challenge trials, comprising 1312 adults. The studies varied in the duration of the challenge (ranging from 1 day to 6 weeks), daily doses for the gluten challenge (ranging from 2 g to 52 g; 3 studies administered less than 8 g/day), and composition of the placebo (gluten-free products, xylose, whey protein, rice, or corn starch containing fermentable carbohydrates). Most of the stu…

medicine.medical_specialtyGlutensGluten sensitivityPlacebodigestive systemGastroenterologyDouble blind03 medical and health sciences0302 clinical medicinegluten-free dietInternal medicineMedicineHumansIn patient030212 general & internal medicineFood scienceceliac disease; gluten-free diet; irritable bowel syndrome; wheat allergyIrritable bowel syndromechemistry.chemical_classificationirritable bowel syndromeHepatologybusiness.industryDiagnostic Tests RoutineGastroenterologynutritional and metabolic diseasesmedicine.diseaseGlutendigestive system diseaseswheat allergychemistry030211 gastroenterology & hepatologyControlled Clinical Trials as TopicFODMAPbusinessWheat allergyceliac diseaseFood Hypersensitivity
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