Search results for "Core"
showing 10 items of 1999 documents
Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion
2001
The structural protein VP6 of rotavirus, an important pathogen responsible for severe gastroenteritis in children, forms the middle layer in the triple-layered viral capsid. Here we present the crystal structure of VP6 determined to 2 A resolution and describe its interactions with other capsid proteins by fitting the atomic model into electron cryomicroscopic reconstructions of viral particles. VP6, which forms a tight trimer, has two distinct domains: a distal beta-barrel domain and a proximal alpha-helical domain, which interact with the outer and inner layer of the virion, respectively. The overall fold is similar to that of protein VP7 from bluetongue virus, with the subunits wrapping …
A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses.
2002
Virus like particles (VLPs) are known to induce potent B cell responses in the absence of adjuvants. Moreover, epitope-specific antibody responses may be induced by VLPs that contain peptides inserted in their immunodominant regions. However, due to steric problems, the size of the peptides capable of being incorporated into VLPs while still permitting capsid assembly, is rather limited. While peptides genetically fused to either the N- or C-terminus of VLPs present fewer assembly problems, the immune responses obtained against such epitopes are often limited, most likely because the epitopes are not optimally exposed. In addition, such particles may be less stable in vivo. Here, we show th…
Intentional replantation for the management of maxillary sinusitis.
2007
AIM: To present a case that emphasizes the importance of the use of intentional replantation as a technique to successfully treat a periapical lesion and an odontogenic maxillary sinusitis through the alveolus at the same time. SUMMARY: This case report presents a patient with odontogenic maxillary sinusitis secondary to periapical disease of a maxillary molar that had previously received root canal treatment. The molar was extracted, with drainage and rinsing of the maxillary sinus. The apices were resected extra-orally, the retrograde cavities prepared with ultrasound and retrograde fillings of silver amalgam placed. The tooth was then replanted. After 2 years, the patient was asymptomati…
Quantum and carbon dots conjugated molecularly imprinted polymers as advanced nanomaterials for selective recognition of analytes in environmental, f…
2021
Abstract Samples with complex matrix analyzed during explanation of pathogenesis of various diseases and food or environmental monitoring request advanced analytical and instrumental devices. Among the materials used for described purposes, quantum (QDs) or carbon dots (CDs) layered by molecularly imprinted polymer (MIP) shells have gained widespread attention. Unique optical and physicochemical properties of QDs/CDs together with high MIPs selectivity make the QD/CD-MIP conjugates capable of adsorbing specific target molecules – such a binding event is then transduced as the optical signal of the response by the QDs/CDs. This review includes brief introduction on principles of imprinting p…
The low-latitude monsoon climate during Dansgaard–Oeschger cycles and Heinrich Events
2000
During the last 100,000 years Dansgaard–Oeschger cycles (D/O cycles) and Heinrich Events have been the dominant signal of past climate variability over Greenland and the North Atlantic. The succession of stadials (cold) and interstadials (warm) associated with these cycles has been documented in records from the entire northern hemisphere, South America, New Zealand, Antarctica, the South Atlantic and the Southern Ocean. Evidently, climate forcing in the D/O band affects both hemispheres. The origin and cause of these teleconnected patterns is still unknown, even if a large proportion of the cooling in Europe and northern Asia during Heinrich Events is a meteorological response to cold surf…
On the potential of NoC virtualization for multicore chips
2008
As the end of Moores-law is on the horizon, power becomes a limiting factor to continuous increases in performance gains for single-core processors. Processor engineers have shifted to the multicore paradigm and many-core processors are a reality. Within the context of these multi-core chips, three key metrics point themselves out as being of major importance, performance, fault-tolerance (including yield), and power consumption. A solution that optimizes all three of these metrics is challenging. As the number of cores increases the importance of the interconnection network-on-chip (NoC) grows as well, and chip designers should aim to optimize these three key metrics in the NoC context as …
Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy
2020
Background Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its intensity. The objective of this study was to determine the effect of zinc in OM in children with acute leukemia in the early stages of oncological treatment. Material and Methods This quasi-experimental study evaluated OM in 2 groups (control group: conventional hospital management, and experimental group: administration of 50 mg of zinc gluconate daily plus conventional hospital management). OM severity was recorded at a two-month follow-up. Results Forty-nine patients (26 i…
The Acts project: track reconstruction software for HL-LHC and beyond
2019
The reconstruction of trajectories of the charged particles in the tracking detectors of high energy physics experiments is one of the most difficult and complex tasks of event reconstruction at particle colliders. As pattern recognition algorithms exhibit combinatorial scaling to high track multiplicities, they become the largest contributor to the CPU consumption within event reconstruction, particularly at current and future hadron colliders such as the LHC, HL-LHC and FCC-hh. Current algorithms provide an extremely high standard of physics and computing performance and have been tested on billions of simulated and recorded data events. However, most algorithms were first written 20 year…
Concept and Development of Modular VLIW Processor Based on FPGA
2010
Modern FPGA chips, with their larger memory capacity and reconfigurability potential, are opening new frontiers in rapid prototyping of embedded systems. With the advent of high density FPGAs it is now possible to implement a high performance VLIW processor core in an FPGA. Architecture based on Very Long Instruction Word (VLIW) processors are an optimal choice in the attempt to obtain high performance level in embedded system. In VLIW architecture, the effectiveness of these processors depends on the ability of compilers to provide sufficient instruction level parallelism(ILP) in program code. Using advanced compiler technology could take these functions, This paper describes research resu…
Multiple modular very long instruction word processors based on field programmable gate arrays
2007
Modern field programmable gate array (FPGA) chips, with their large memory capacity and reconfigurability potential, are opening new frontiers in rapid prototyping of embedded systems. With the advent of high-density FPGAs, it is now possible to implement a high-performance very long instruction word (VLIW) processor core in an FPGA. This paper describes research results about enabling the DSP TMS320 C6201 model for real-time image processing applications by exploiting FPGA technology. We present a modular DSP C6201 VHDL model with a variable instruction set. We call this new development a minimum mandatory modules (M3) approach. Our goals are to keep the flexibility of DSP in order to shor…