Search results for "Core"

Corrigendum to “Polyvascular subclinical atherosclerosis in familial hypercholesterolemia: The role of cholesterol burden and gender” [Nutr Metab Car…

2019

International audience; Background and aim: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disease characterized by a heterogeneous phenotype. The assessment of cardiovascular (CV) risk is challenging for HeFH. Cholesterol burden (CB) allows to estimate the lifelong exposure to high levels of cholesterol. The aim of this study was to analyze the distribution of subclinical athero-sclerosis and the relationship between atherosclerosis and the CB in a sample of HeFH patients, focusing on sex-related differences. Methods and Results: 154 asymptomatic HeFH subjects underwent coronary-artery-calcium score (CACs) and Doppler ultrasound of carotid and femoral arteries. Yearly lipid…

Pressurized intraperitoneal aerosol chemotherapy with cisplatin and doxorubicin or oxaliplatin for peritoneal metastasis from pancreatic adenocarcino…

2020

Background: Systemic chemotherapy for pancreatic adenocarcinoma (PDAC) and cholangiocarcinoma (CC) with peritoneal metastases (PM) is affected by several pharmacological shortcomings and low clinical efficacy. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is expected to maximize exposure of peritoneal nodules to antiblastic agents. This study aims to evaluate safety and efficacy of PIPAC for PM of PDAC and CC origin. Methods: This is a retrospective analysis of consecutive PDAC and CC cases with PM treated with PIPAC at two European referral centers for peritoneal disease. We prospectively recorded from August 2016 to May 2019 demographic, clinical, surgical, and oncological data…

Conditions for achieving invisibility of hyperbolic multilayered nanotubes

2016

Invisibility of nanotubes has recently been demonstrated in highly anisotropic metamaterials in the transition regime from hyperbolic to elliptic dispersion [Sci. Rep. 5 (2015) 16027]. In such study, the characterization of a realistic multilayered metamaterial was carried out by means of an effective medium approach providing average components of the permittivity tensor and wave fields. Here, the edge effects of the metal-dielectric stratified nanotube for different combinations were thoroughly analyzed. We show how the boundary layers, which in principle remain fully irrelevant in the estimation of the effective permittivity of the nanotube, however play a critical role in the scattering…

How important is culture to understand political protest?

2021

Abstract The literature considers nonviolent protests among the most important predictors of transitions towards democracy and democratic reforms. This study addresses the conditionsmaking countries more likely to experience nonviolent instead of violent forms of protest. While the literature emphasizes economic and political predictors of protest at the country level, we expand the study of nonviolent-vs-violent protest by incorporating cultural predictors. To do so, we use a newly developed time-pooled cross-sectional database covering an established set of orientations from the World Values Survey, known as “emancipative values”. Estimating the prevalence of these values at the country l…

Steroidal saponins from Dioscorea preussii.

2014

Abstract Three new steroidal saponins, named diospreussinosides A–C (1–3), along with two known ones (4, 5) were isolated from rhizomes of Dioscorea preussii. Their structures were elucidated mainly by 1D and 2D NMR spectroscopic analysis and mass spectrometry as (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O-α- l -rhamnopyranosyl-(1 → 4)-α- l -rhamnopyranosyl-(1 → 4)-β- d -glucopyranoside (1), (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O-α- l -rhamnopyranosyl-(1 → 4)-α- l -rhamnopyranosyl-(1 → 4)-[α- l -rhamnopyranosyl-(1 → 2)]-β- d -glucopyranoside (2), and (24S,25R)-17α,24,25-trihydroxyspirost-5-en-3β-yl-O-α- l -rhamnopyranosyl-(1 → 4)-α- l -rhamnopyranosyl-(1 → 4)-[α- l -rhamnopyranosyl-(1 → …

Liver stiffness, a non-invasive marker of liver disease: a core study group report

2010

The ability to evaluate liver stiffness non-invasively in clinical practice by measuring transient elastography using FibroScan® has resulted in considerable interest and enthusiasm. A core study group, organized by the Italian Association for the Study of the Liver, has assessed the usefulness of FibroScan® in the diagnosis and management of liver disease in clinical practice. The group concluded that FibroScan® is a valuable, non-invasive technique and have developed a consensus report form for registering transient elastography results. In this article, we report the findings of the study group.

P.0170 Distinct polygenic risk scores in clusters of psychotic subjects with different premorbid trajectories and current IQ

2021

Are Polygenic Risk Scores for Major Mental Disorders Associated with General or Specific Psychosis Symptom dimensions?

2019

Background Psychotic symptoms can be conceptualised as dimensions of psychopathology cutting across diagnostic boundaries. Thus, they might be considered enhanced quantitative phenotypes to relate to genetic variants as summarised by Polygenic Risk Scores (PRSs) for Major Mental Disorders (MMDs), including Schizophrenia (SZ), Bipolar Disorder (BP), and Major Depressive Disorder (MDD). The objectives of this study were to: 1) identify the dimensional structure of symptoms at First Episode Psychosis (FEP), testing whether a bi-factor model statistically fits the conceptualization of psychosis as a single common construct (general psychosis factor) while also recognising multidimensionality (p…

Phase transitions in a colloidal dispersion flowing through a cylindrical capillary

2008

The flow of a charged-stabilized colloidal dispersion of crystalline equilibrium structure through a cylindrical capillary is investigated. The simultaneous existence of up to three differently ordered states is observed under conditions of stationary flow. The evolution of their concentric arrangement along the capillary is determined by Bragg microscopy. For sufficient low fluxes, stationary phase distributions are obtained. While the apparent viscosity is non-monotonous and non-Newtonian, the corresponding velocity profiles are found to be piecewise parabolic and are compatible to numerical calculations. Furthermore, we test the assumption of a constant yield stress determining the radia…

Core-Shell Microgels with Switchable Elasticity at Constant Interfacial Interaction.

2016

Hydrogels based on poly(N-isopropylacrylamide) (pNIPAAm) exhibit a thermo-reversible volume phase transition from swollen to deswollen states. This change of the hydrogel volume is accompanied by changes of the hydrogel elastic and Young's moduli and of the hydrogel interfacial interactions. To decouple these parameters from one another, we present a class of submillimeter sized hydrogel particles that consist of a thermosensitive pNIPAAm core wrapped by a nonthermosensitive polyacrylamide (pAAm) shell, each templated by droplet-based microfluidics. When the microgel core deswells upon increase of the temperature to above 34 °C, the shell is stretched and dragged to follow this deswelling i…