Search results for "Core"
showing 10 items of 1999 documents
Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance
2022
Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods We profiled 2,083 serum miRNAs in a discovery cohort (183 cases with NAFLD representing the complete NAFLD spectrum and 10 population controls). miRNA libraries generated by HTG EdgeSeq were sequenced by Illumina NextSeq. Selected serum miRNAs were profiled in 372 additional cases with NAFLD and 15 population controls by quantitative reverse transcriptase PCR. Results Levels of 275 miRNAs differed between cases and population controls. Fewer differences were seen wi…
Valodu centru mājaslapu analīze
2018
Šajā darbā uzmanība tiek veltīta galvenokārt Humanitāro zinātņu fakultātes Lietišķās valodniecības centra (LVC) apakšvietnes satura analīzei. Darba mērķis ir noteikt LVC mājaslapas semantiskos kodolus un pārbaudīt vietnes atslēgvārdu un atslēgu vārdkopu saderību Google meklētājprogrammā. Analīze tika veikta ar moderno Google rīku palīdzību un manuāli atpazīstot pašreizējos atslēgvārdus un atslēgu vārdkopas tīmekļa vietnes lapās. Šis pētījums uzsver semantiskā kodola sagatavošanas nozīmi pirms mājaslapas izstrādāšanas, kā arī to, kā ik pa laikam var pārbaudīt atslēgvārdu un atslēgu vārdkopu saderību (Google atpazīšanu). Empīriskais pētījums tika īstenots izmantojot kvalitatīvo un kvantitatīv…
Sorafenib for Hepatocellular Carcinoma: From Randomized Controlled Trials to Clinical Practice.
2015
Hepatocellular carcinoma is a challenging malignancy of global importance. It is the sixth most common solid malignancy and the third leading cause of cancer-related death, worldwide. Curative treatments at early stages include liver transplantation, resection and percutaneous ablation, while transarterial chemoembolization can improve survival in patients with intermediate tumor stage. Patients with mild, related symptoms and/or macrovascular invasion or extrahepatic spread are classified under the advanced stage. The standard of care in this group is sorafenib, an inhibitor of Raf kinase and vascular endothelial growth factor receptor, whose effectiveness has been proven by 2 recent rando…
(Table 1) Age determination of sediment profile SO90-41KL/63KA
2002
The 14C ages of planktonic foraminifers Globigerinoides sacculifer bracketing the Younger Dryas in a d18O record of Globigerinoides ruber from a laminated sediment core on the Pakistani continental margin suggest that surface reservoir ages in the Arabian Sea were in excess of 1000 years during the deglaciation. A least squares error fit of a detailed 14C chronology to the (atmospheric) tree ring record gave variable early Holocene reservoir ages between 780 and 1120 years, well above the prebomb value of 640 years. Mid-Holocene reservoir ages are less well constrained but were probably closer to the prebomb value. The method used to fit individual core sections to the tree ring record was …
Quantifying connected discourse in Spanish-speaking individuals with aphasia: The case of mixed aphasias
2017
• Characterization of mixed cases of aphasia, the most commonly attested in clinical practice.
Estratificación del riesgo de pacientes con dolor torácico sin elevación del segmento ST en la puerta de urgencias
2003
Objectives. To investigate the prognostic factors in patients who come to the emergency room with chest pain but without ST segment elevation. Patients and method. 743 consecutive patients were evaluated by recording clinical history, electrocardiogram and troponin I determination, and early (< 24 h) exercise testing was done for the low-risk subgroup of patients (n = 203). All patients were followed during 3 months for major events (acute myocardial infarction or death). Results. Major events occurred in 71 patients (9.6%). Multivariate analysis (C stadistic = 0.79; 95% CI 0.730.84; p = 0.0001) identified the following predictors: age ≥ 72 years (OR = 1.7; 95% CI, 1.0-2.9; p = 0.05), insul…
Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study
2022
[Purpose] The effect of high-dose imatinib (800 mg/day) on survival in the adjuvant treatment of patients with resected KIT exon 9–mutated gastrointestinal stromal tumors (GIST) is not established. Here, the association of dose and other clinicopathologic variables with survival was evaluated in a large multi-institutional European cohort.
(Table 2) Age determination of sediment core NIOP-C2_929
2007
In this study we present a sea surface temperature (SST) record from the western Arabian Sea for the last 20,000 years. We produced centennial-scale d18O and Mg/Ca SST time series of core NIOP929 with focus on the glacial-interglacial transition. The western Arabian Sea is influenced by the seasonal NE and SW monsoon wind systems. Lowest SSTs occur during the SW monsoon season because of upwelling of cold water, and highest SSTs can be found in the low-productivity intermonsoon season. The Mg/Ca-based temperature record reflects the integrated SST of the SW and NE monsoon seasons. The results show a glacial-interglacial SST difference of ~2°C, which is corroborated by findings from other Ar…
Penalized logistic regression for small or sparse data: interval estimators revisited
2015
This paper focuses on interval estimation in logistic regression models fitted through the Firth penalized log-likelihood. In this context, many authors have claimed superiority of the Likelihood ratio statistic with respect to the (wrong) Wald statistic via simulation evidence. We re-assess such findings by detailing the inferential tools also including in the comparisons the (right) Wald statistic and other statistics neglected in previous literature. In particular, we assess performances of the CIs estimators by simulation and compare them in a real data set. Differently from previous findings, the Likelihood ratio statistic does not appear to be the best inferential device in Firth pena…
The role of the silicatein-alpha interactor silintaphin-1 in biomimetic biomineralization.
2008
Biosilicification in sponges is initiated by formation of proteinaceous filaments, predominantly consisting of silicateins. Silicateins enzymatically catalyze condensation of silica nanospheres, resulting in symmetric skeletal elements (spicules). In order to create tailored biosilica structures in biomimetic approaches it is mandatory to elucidate proteins that are fundamental for the assembly of filaments. Silintaphin-1 is a core component of modularized filaments and also part of a spicule-enfolding layer. It bears no resemblance to other proteins, except for the presence of an interaction domain that is fundamental for its function as scaffold/template. In the presence of silicatein sil…