Search results for "Coste"

Competition for resources modulates cell-mediated immunity and stress hormone level in nestling collared doves (Streptopelia decaocto)

2008

International audience; Competitive stress imposed by hatching asynchrony may affect developmental trajectories of offsprings by regulating resource allocation between growth and other fitness-related traits. For instance, the down-regulation of immunity is a commonly observed phenomenon under stressful conditions. However, physiological mechanisms that regulate resources allocation to growth and immune functions in response to competition for resources, as well as inter-sexual differences in physiological strategies, are still poorly investigated. To partially fill this gap, we first conducted a descriptive study on chicks of the collared dove (Streptopelia decaocto), a species producing t…

Corticosteroids in oncology: Use, overuse, indications, contraindications. An Italian Association of Medical Oncology (AIOM)/ Italian Association of …

2022

Corticosteroids (CSs) are widely used in oncology, presenting several different indications. They are useful for induction of apoptosis in hematological neoplasms, for management of anaphylaxis and cytokine release/hypersensitivity reaction and for the symptomatic treatment of many tumour- and treatment-related complications. If the employment of CSs in the oncological setting results in several benefits for patients and satisfaction for clinicians, on the other hand, many potential adverse events (AEs), both during treatment and after withdrawal of CSs, as well as the duality of the effects of these compounds in oncology, recommend being cautious in clinical practice. To date, several gray…

Forest management is associated with physiological stress in an old–growth forest passerine

2003

We investigated how physiological stress in an area-sensitive old-growth forest passerine, the Eurasian treecreeper (Certhia familiaris), is associated with forest fragmentation and forest structure. We found evidence that the concentrations of plasma corticosterone in chicks were higher under poor food supply in dense, young forests than in sparse, old forests. In addition, nestlings in large forest patches had lower corticosterone levels and a better body condition than in small forest patches. In general, corticosterone levels were negatively related to body condition and survival. We also found a decrease in corticosterone levels within the breeding season, which may have been a result …

Profile of intranasal corticosteroids in italy: Safety, cost/effectiveness, local and systemic adverse effects

2014

Background: Allergic Rhinitis is a common and often debilitating disease that affect, nowadays, not only young people. For this reason an effective treatment is necessary to minimize the impact of allergic rhinitis in general population. Objective: The aim of this review is to inquire intranasal corticosteroids. Results: We have obtained several randomized, double-blind, placebo-controlled clinical trials, by a MEDLINE search. We analyzed the safety profile, the adverse effects described by the authors, the relation between cost/effectiveness. We have made a search for trade profile, dosage and chemical characteristics by on-line handbook. Discussion: Several studies demonstrate that intran…

Modificazioni recenti della linea di costa connesse con l’azione antropica: esempi dalla Sicilia.

2008

Reducción de los costes de las empresas por la certificación en las normas ISO 9000 de calidad

2004

En este trabajo presentamos los resultados obtenidos mediante una encuesta postal a las empresas certificadas en la norma ISO 9000 de la Comunidad Valenciana. El objetivo fundamental es saber si el ahorro de costes que produce la certificación en las normas ISO 9000 de calidad es mayor que los costes que ocasiona, así como las variables influyen en la reducción de los costes. Los resultados son: El 43% de empresas reducen sus costes totales El porcentaje de ahorro que consiguen es del 9.45% de media. Cuantos más años llevan las empresas certificadas, cuanto mayor es la empresa, el sector industrial, si la empresa es exportadora, las motivaciones por las que se certificaron, el tener una bue…

Los costes de calidad en las empresas certificadas en la norma ISO 9000 de la Comunidad Valenciana

2005

En este trabajo estudiamos la evolución de los costes de calidad en las empresas que se han certificado en las normas ISO 9000 de calidad. La metodología ha sido un estudio empírico con una muestra de las empresas certificadas en la Comunidad Valenciana. Algunos de los resultados son que las empresas reducen en términos generales los costes de fallos internos y externos y aumentan los de prevención y evaluación al certificarse en las normas ISO 9000. También destacamos que son pocas las empresas que mides estos costes sobre todo por tratarse de empresas certificadas

Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist

2015

Chronic obstructive pulmonary disease (COPD) is characterised by chronic pulmonary inflammation punctuated by periods of viral exacerbations. Recent evidence suggests that the combination of roflumilast with corticosteroids may improve the compromised anti-inflammatory properties of corticosteroids in COPD. We analyzed differential and combination anti-inflammatory effects of dexamethasone and roflumilast N-oxide in human bronchial epithelial cells (HBECs) stimulated with viral toll like receptor (TLR) agonists. Lung tissue and HBECs were isolated from healthy (n = 15), smokers (n = 12) and smokers with COPD (15). TLR3 expression was measured in lung tissue and in HBECs. IL-8 secretion was …

The effects of glucocorticoids on thymidine kinase and nucleoside phosphotransferase during development of chicken embryo retina.

1983

AbstractThymidine kinase in chick embryo retina reaches its highest values on the 8–10th day of development, then declines reaching the lowest value at hatching. The rate of DNA synthesis essentially follows this activity while, in contrast, nucleoside phosphotransferase increases progressively during development. Glucocorticoids at 5 × 10−6M lower the level of thymidine kinase in isolated retinas of chick embryo. The most effective steroid was hydrocortisone. The effect was observed in retinas from 8–18-day-old chick embryo and, except on the 18th day, was always of the same magnitude. We suggest that a glucocorticoid can be the natural factor responsible for the marked fall in thymidine k…

Mucoadhesive Solid Lipid Microparticles (SLM) for sustained release of corticosteroids to the lungs

2016

Pulmonary delivery is the preferred route of drug administration in the treatment of many respiratory disease, such as asthma and chronic obstructive pulmonary disease (COPD). Over the years, several kinds of carriers have been studied for sustained release of corticosteroids and bronchodilators to the lungs. Solid Lipid Microparticles (SLM) due to their biocompatibility and size (3-5 µm) can reach the bronchial epithelium directly, circumvent first pass metabolism and avoid systemic toxicity [1,2]. In this work we describe the preparation and the characterization of two different systems subjected to chitosan and alginate coating for sustained release of fluticasone propionate (FP) into th…