Search results for "Coste"

showing 10 items of 368 documents

Beliefs and preferences regarding biological treatments for severe asthma

2020

Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as throu…

Severe asthmaBehavior; Belief; Biological drug; Severe asthmainterleukine 5 IgEMULTICENTERDiseaseOmalizumabADD-ON THERAPYBehavior Belief Biological drug Severe asthmaDOUBLE-BLIND0302 clinical medicineMedicine and Health SciencesImmunology and AllergyEosinophil IL5 [Eos]030223 otorhinolaryngologyPulmonologistssevere asthma biological drug belief behavior3. Good healthBeliefSAFETYmedicine.druglcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinemedicine.medical_specialtyEos: Eosinophil IL5ImmunologyBiological drugSpecialtylong-acting beta2-agonist OMASocio-culturaleSettore MED/10 - Malattie Dell'Apparato RespiratorioArticle03 medical and health sciencesQuality of life (healthcare)Omalizumab. OMA/IL5 Omalizumab plus anti-IL5 moleculeOMALIZUMABmedicineIntensive care medicineAsthmaBehaviorINterasma Scientific Network LABAbusiness.industryMEPOLIZUMABmedicine.diseaseEFFICACYICS inhaled corticosteroidsLIFE030228 respiratory systemImmunoglobulin E INESNETAllergistslcsh:RC581-607businessMepolizumab
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Benralizumab Effectiveness in Severe Eosinophilic Asthma with and without Chronic Rhinosinusitis with Nasal Polyps: A Real-World Multicenter Study

2021

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) affects around 60% of patients with severe eosinophilic asthma (SEA). Benralizumab was recently approved for SEA add-on treatment. Objective: To assess the real-world effectiveness of benralizumab in SEA with or without CRSwNP. Methods: We conducted a multicenter observational study, including patients with SEA treated with benralizumab for 24 weeks in 12 Italian specialized facilities. Asthma exacerbations, Asthma Control Test (ACT), lung function, oral corticosteroid (OCS) dosage, and eosinophil and basophil count in peripheral blood were recorded at baseline and after 4, 12, and 24 weeks. The 22-item Sino-Nasal Outcome Test (S…

Severe asthmaVital capacitymedicine.medical_specialtymedicine.drug_classSettore MED/10 - Malattie Dell'Apparato RespiratorioAntibodies Monoclonal HumanizedFEV1/FVC ratiochemistry.chemical_compoundNasal PolypsInternal medicinemedicineHumansImmunology and AllergyNasal polypsAnti-Asthmatic AgentsIL-5Nasal polypbusiness.industryMinimal clinically important differenceBenralizumabFunctional endoscopic sinus surgeryrespiratory systemEosinophilBenralizumabmedicine.diseaseAsthmaChronic rhinosinusitismedicine.anatomical_structureReal-worldchemistryChronic rhinosinusitiCorticosteroidbusinessHumanThe Journal of Allergy and Clinical Immunology: In Practice
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¿Por qué existen los bancos?

2004

La incorporación reciente a la teoría bancaria contemporánea de las herramientas de análisis de las teorías de la agencia y de la economía de la información ha modificado nuestra visión tradicional del negocio bancario, ampliando las funciones que realizan estos intermediarios. El estudio de estas funciones y de las ventajas comparativas que poseen los bancos en el ejercicio de las mismas constituirá el eje central de nuestro trabajo. De los resultados de este análisis concluiremos que la existencia de los bancos se justifica porque estas entidades, a través de las funciones que realizan, permiten una mejor colocación de los recursos financieros, beneficiando a demandantes y oferentes de fo…

Sistema bancario; Coste de transacción; Información; Riesgo financiero Pagos; Liquidez bancaria; Intermediación financiera; Activos financieros; Pasivos financierosUNESCO::CIENCIAS ECONÓMICAS::Actividad económica::Dinero y operaciones bancarias
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N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

2021

Appropriately responding to stressful events is essential for maintaining health and well-being of any organism. Concerning social stress, the response is not always as straightforward as reacting to physical stressors, e.g., extreme heat, and thus has to be balanced subtly. Particularly, regulatory mechanisms contributing to gaining resilience in the face of mild social stress are not fully deciphered yet. We employed an intrinsic social hierarchy stress paradigm in mice of both sexes to identify critical factors for potential coping strategies. While global transcriptomic changes could not be observed in male mice, several genes previously reported to be involved in synaptic plasticity, l…

Social stressMethyltransferase complexbehaviorQH301-705.5sex differenceStressorCell BiologyBiologydominancechemistry.chemical_compoundtranscriptomicschemistryCorticosteroneepigenetic modificationSynaptic plasticityChronic stressmethyltransferaseMRNA methylationN6-MethyladenosineBiology (General)NeuroscienceDevelopmental BiologyFrontiers in Cell and Developmental Biology
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Effects of chronic treatment with testosterone propionate on aggression and hormonal levels in intact male mice.

1998

Effects of testosterone propionate, an anabolic-androgenic steroid (AAS), on aggression in gonadally intact male mice were examined. Animals were given weekly injections of 3.75, 7.5, 15, and 30 mg/kg of drug or sesame oil for 10 weeks. During the last 3 weeks, behavioral tests were conducted and at the end of the experiment, body, liver and testes weight and hormonal data were collected. The treatment had minimal behavioral and endocrine effects. It resulted in shorter latencies of 'threat' only in the last agonistic encounter, increases in testosterone levels and decreases in testes weight in a non-linear dose-dependant way. The action of treatment was different on threat and attack, the …

Testosterone propionateMalemedicine.medical_specialtymedicine.drug_classEndocrinology Diabetes and MetabolismIndividualityTesticlechemistry.chemical_compoundMiceEndocrinologyAnabolic AgentsCorticosteroneInternal medicinemedicineAgonistic behaviourAnimalsTestosteroneSocial BehaviorBiological PsychiatryTestosteroneDose-Response Relationship DrugEndocrine and Autonomic SystemsAggressionAndrogenAggressionPsychiatry and Mental healthmedicine.anatomical_structureEndocrinologychemistrymedicine.symptomPsychologyArousalCorticosteroneAgonistic BehaviorHormonePsychoneuroendocrinology
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Update on the Management of Pediatric Psoriasis: An Italian Consensus

2022

Introduction Psoriasis affects children with a considerable burden in early life. Treating pediatric psoriasis is challenging also because of the lack of updated specific guidelines. With the recent approval of several biologics for pediatric psoriasis and the ongoing COVID-19 pandemic, the management of young psoriatic patients is facing major changes. A revision of treatment recommendations is therefore needed. Methods In September 2021, a board of six Italian dermatologists convened to update treatment recommendations. The board issued evidence- and consensus-based statements covering relevant areas of pediatric psoriasis, namely: assessment of psoriasis severity, management of children …

Topical corticosteroidsAdolescentBiologicSystemic therapyCorticosteroid-sparingHealth-related quality of lifePediatric psoriasisDermatologyBiologicsAdolescentsPlaque psoriasiAdolescents; Biologics; Children; Corticosteroid-sparing; Health-related quality of life; Pediatric psoriasis; Plaque psoriasis; Systemic therapy; Topical corticosteroidsSettore MED/35Pediatric psoriasiPlaque psoriasisSettore MED/35 - MALATTIE CUTANEE E VENEREEChildren
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Repercusión en la productividad de las empresas por la implantación de los sistemas de calidad a través de los costos de calidad

2008

Es indudable que la calidad es una variable estratégica relevante en un entorno competitivo, que garantiza cuotas de mercado mayores y tasas de beneficios que, normalmente, son crecientes con el nivel de calidad. Esta afirmación se relativiza cuando introducimos consideraciones de costos. Esta ponencia es una aproximación empírica al análisis de los costos de calidad, así como de los sistemas, metodologías y herramientas de gestión de la calidad. Se han contrastado varias hipótesis con tests estadísticos aplicados a información procedente de encuestas de 182 empresas españolas certificadas en la Norma ISO 9000. Además de obtener una panorámica descriptiva referente a los costos y la gestión…

UNESCO::CIENCIAS ECONÓMICAS:CIENCIAS ECONÓMICAS [UNESCO]Costes de calidad ISO 9000 Calidad Total Comunidad Valenciana
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¿Por qué existen los bancos?

2004

Victor.E.Barrios@uv.es La incorporación reciente a la teoría bancaria contemporánea de las herramientas de análisis de las teorías de la agencia y de la economía de la información ha modificado nuestra visión tradicional del negocio bancario, ampliando las funciones que realizan estos intermediarios. El estudio de estas funciones y de las ventajas comparativas que poseen los bancos en el ejercicio de las mismas constituirá el eje central de nuestro trabajo. De los resultados de este análisis concluiremos que la existencia de los bancos se justifica porque estas entidades, a través de las funciones que realizan, permiten una mejor colocación de los recursos financieros, beneficiando a demand…

UNESCO::CIENCIAS ECONÓMICAS::Economía sectorial::Finanzas y segurosSistema bancario ; Coste de transacción ; Información ; Riesgo financiero ; Pagos ; Liquidez bancaria ; Intermediación financiera ; Activos financieros ; Pasivos financieros
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Dibujos de Ximo Sanchis. La construcción del territorio valenciano

2021

Los dibujos del arquitecto Ximo Sanchis (1946) son una parte relevante de su visión de la arquitectura complementaria a sus proyectos y obras. Estas dos vertientes, dibujo y arquitectura, confluyen en una interpretación del territorio del País Valenciano que es significativa de los cambios que ha experimentado durante las últimas décadas. Una reflexión que se despliega en diferentes niveles. Por un lado, la imagen antrópica como síntesis de las construcciones ligadas al cultivo de regadío se complementa con las perspectivas de los terrenos de secano y los huertos de palmeras como rasgos históricos relevantes de este paisaje. Por otro, el panorama de la costa, invadida por los usos vacaciona…

UNESCO::HISTORIApanorama costeroterritorio valencianodibujo arquitectónico:HISTORIA [UNESCO]perfil urbano
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El coste de la vida en la universidad

2003

International audience

Universidad[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationCoste de la vida[ SHS.EDU ] Humanities and Social Sciences/EducationEtudiant[SHS.ECO]Humanities and Social Sciences/Economics and FinanceVieEnseignement supérieurUniversitéJEL : I - Health Education and WelfareJEL: I - Health Education and Welfare[ SHS.ECO ] Humanities and Social Sciences/Economies and financesCoût de l'enseignement[SHS.ECO] Humanities and Social Sciences/Economics and FinanceCoûtComputingMilieux_MISCELLANEOUS
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