Search results for "Cox1"

showing 2 items of 22 documents

Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low…

2014

SPE IPM UB; International audience; : The peroxisomal 3-ketoacyl-CoA thiolase B (ThB) catalyzes the thiolytic cleavage of straight chain 3-ketoacyl-CoAs. Up to now, the ability of ThB to interfere with lipid metabolism was studied in mice fed a routinely laboratory chow enriched or not with the synthetic agonist Wy14,643, a pharmacological activator of the nuclear hormone receptor PPARα. The aim of the present study was therefore to determine whether ThB could play a role in obesity and lipid metabolism when mice are chronically fed a synthetic High Fat Diet (HFD) or a Low Fat Diet (LFD) as a control diet. To investigate this possibility, wild-type (WT) mice and mice deficient for Thb (Thb(…

lathosterol.medicine.medical_specialtymedicine.drug_classLathosterolCarbohydrate metabolismBiologyCholesterol 7 alpha-hydroxylaseDiet High-FatBiochemistrylathosterolBile Acids and Saltschemistry.chemical_compoundMiceInternal medicineIntestine Smallmedicine[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyAnimals[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyInsulin-Like Growth Factor I[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology2. Zero hunger[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismbile acidsBile acidFatty acid metabolismCholesterolCholesterol HDLfood and beveragesLipid metabolismGeneral Medicine[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismAcetyl-CoA C-AcyltransferaseDietary FatsLiver GlycogenEndocrinologyCholesterolGlucosehypoglycemiade novo biosynthesis of cholesterolchemistryGrowth HormoneACOX1lipids (amino acids peptides and proteins)peroxisomal 3-ketoacyl-CoA thiolase B
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Phenotypic and genetic characterization of emerging trematodiasis: Fascioliasis and Schistosomiasis

2021

La Fascioliasis y la Esquistosomiasis son dos importantes trematodiasis (re)emergentes con gran impacto en la salud humana. Dada la necesidad de caracterizar las poblaciones de Trematodos involucradas, los objetivos de la presente investigación son: en primer lugar, analizar el impacto de la reinfección experimental por Fasciola hepatica en los fenotipos inmunológicos, clínicos y biológicos por medio de un diseño experimental que reproduce las condiciones habituales de reinfección/cronicidad en las zonas endémicas de la Fascioliasis humana; en segundo lugar, la caracterización fenotípica morfológica de huevos de Schistosoma haematobium de migrantes subsaharianos con Esquistosomiasis urogeni…

migrantsbovisreinfectionTh1CIASTh2sheddingepgmorphologyspainhaematobiumPCACVAmorphometricsIgG1hepaticaemergingfasciolamansoni:CIENCIAS MÉDICAS [UNESCO]anemiacytokinescox1TregUNESCO::CIENCIAS MÉDICASschistosomaeggTh17ITSmorphometry
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