Search results for "Crest"

The effect of bone marrow-derived stem cells associated with platelet-rich plasma on the osseointegration of immediately placed implants

2020

Background Stem cells associated with growth factors have been shown to improve bone healing and the osseointegration of dental implants. A Brazilian miniature pig model was used to evaluate the effect of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) associated with platelet-rich plasma (PRP) on the osseointegration of immediately placed dental implants. Material and methods A total of four male adult miniature pigs were used in this study. BM-MSCs from each pig were isolated from the iliac crest and expanded in vitro. The undifferentiated BM-MSCs were mixed with autologous PRP and implanted in the post-extraction sockets at the experimental sites before implant placement …

The value of by-catch data: how species-specific surveys can serve non-target species

2019

Camera trapping has a wide range of research application, but, while research designs are often focused on the study of a single focal species, cameras can also record other non-target species. Occupancy modeling using by-catch data can be a valuable resource to gain information on these species maximizing the scientific effort and efficiency of wildlife surveys. In this study, we used by-catch data from a European wildcat (Felis silvestris silvestris) survey in Southern Italy to assess the habitat covariates determinant for the occupancy of the crested porcupine (Hystrix cristata). We recorded 33 detections at 17 out of 51 cameras (naive occupancy = 0.33). The best models fitted the data w…

Spatial Context of Breeding Ponds and Forest Management Affect the Distribution and Population Dynamics of the Great Crested Newt

2016

Intensive forest management and landscape degradation are threats to amphibian populations. We modelled and compared the extinction and colonization dynamics of the great crested newt in four different spatial contexts that describe landscape change from past to present and future forest landscapes in eastern Finland. In future landscape scenarios, we explored the effects of two forest use intensities with different logging rotation times. The introduction of fish into breeding ponds has been the main cause of local extinctions of the great crested newt. In the future, intensifying land-use and shorter logging rotation will decrease the connectivity between ponds the most. In conservation p…

Sema3a plays a role in the pathogenesis of CHARGE syndrome

2018

CHARGE syndrome is an autosomal dominant malformation disorder caused by heterozygous loss of function mutations in the chromatin remodeler CHD7. Chd7 regulates the expression of Sema3a, which also contributes to the pathogenesis of Kallmann syndrome, a heterogeneous condition with the typical features hypogonadotropic hypogonadism and an impaired sense of smell. Both features are common in CHARGE syndrome suggesting that SEMA3A may provide a genetic link between these syndromes. Indeed, we find evidence that SEMA3A plays a role in the pathogenesis of CHARGE syndrome. First, Chd7 is enriched at the Sema3a promotor in neural crest cells and loss of function of Chd7 inhibits Sema3a expression…

Distance of the alveolar antral artery from the alveolar crest. Related factors and surgical considerations in sinus floor elevation

2016

Background In a variable proportion of maxillary sinuses alveolar antral artery is located close to the residual ridge, increasing the chances for haemorrhagic complications during sinus floor elevation procedures. Material and Methods Retrospective observational study of CBCT explorations performed for implant-treatment planning. The upper first molar area was selected for this study. The relative uncertainty (standard deviation of the measurement divided by its mean and expressed as a percentage from 0% to 100%) was chosen for determining the observational errors. For modeling the chances of AAA detection, the generalized additive models (GAM) approach was chosen. Results A total of 240 m…

How to make a tongue: Cellular and molecular regulation of muscle and connective tissue formation during mammalian tongue development

2018

IF 6.614 (2016); International audience; The vertebrate tongue is a complex muscular organ situated in the oral cavity and involved in multiple functions including mastication, taste sensation, articulation and the maintenance of oral health. Although the gross embryological contributions to tongue formation have been known for many years, it is only relatively recently that the molecular pathways regulating these processes have begun to be discovered. In particular, there is now evidence that the Hedgehog, TGF-Beta, Wnt and Notch signaling pathways all play an important role in mediating appropriate signaling interactions between the epithelial, cranial neural crest and mesodermal cell pop…

11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

2020

High-risk 11q deleted neuroblastomas typically display undifferentiated/poorly differentiated morphology. Neuroblastoma is thought to develop from Schwann cell precursors and undifferentiated neural crest (NC) derived cells. It is therefore vital to understand mechanisms involved in the block of differentiation. We identify an important role for oncogenic ALK-ERK1/2-SP1 signaling in maintenance of undifferentiated NC-derived progenitors via repression of DLG2, a tumor suppressor in neuroblastoma. DLG2 is expressed in the ‘bridge signature’ that represents the transcriptional transition state when neural crest cells or Schwann Cell Precursors become chromaffin cells of the adrenal gland. We …

2021

Maxillofacial hard tissues have several differences compared to bones of other localizations of the human body. These could be due to the different embryological development of the jaw bones compared to the extracranial skeleton. In particular, the immigration of neuroectodermally differentiated cells of the cranial neural crest (CNC) plays an important role. These cells differ from the mesenchymal structures of the extracranial skeleton. In the ontogenesis of the jaw bones, the development via the intermediate stage of the pharyngeal arches is another special developmental feature. The aim of this review was to illustrate how the development of maxillofacial hard tissues occurs via the cra…

Patterns of differentiation in extraosseous Ewing's sarcoma cells. An in vitro study.

1994

BACKGROUND In vitro, tissue culture-associated differentiation assays have facilitated the identification of multiple tumor-cell types. METHODS We have investigated the capability of differentiation of three extraosseous Ewing's sarcoma cell lines toward a neural and muscular direction by in vitro stimulation with dibutyryl cyclic adenosine-monophosphate (db cAMP) and 5-azacytidine, respectively. RESULTS Elongation of cytoplasmic processes and increase of neural markers chromogranin, S-100 protein, and glial fibrillary acidic protein were observed after db cAMP treatment of these lines and neurosecretory granules as well as myelin figures were demonstrated ultrastructurally. These results s…

Significance of pre-treatment panoramic radiographic assessment of edentulous patients-A survey

2010

Objectives: The present study was undertaken to review the significance of pre-treatment panoramic radiographic assessment of edentulous patients, in the dental patient population of Haryana, India. Study Design: In this study a total of 525 completely edentulous patients were selected randomly. A panoramic radiograph was taken using Panoramic machine (Rotagraph plus) and all the radiographs were evaluated by 2 oral radiology specialists for the following clinically significant radiographic findings: retained root fragments, embedded teeth, radiolucencies, radiopacities and location of the mental foramen at the crest of the residual alveolar ridge. The data were analyzed using the chi squar…