Search results for "Cripto"
showing 10 items of 863 documents
Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus
2020
We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini&ndash
Guidelines for biomarker discovery in endometrium: correcting for menstrual cycle bias reveals new genes associated with uterine disorders
2021
Abstract Transcriptomic approaches are increasingly used in reproductive medicine to identify candidate endometrial biomarkers. However, it is known that endometrial progression in the molecular biology of the menstrual cycle is a main factor that could affect the discovery of disorder-related genes. Therefore, the aim of this study was to systematically review current practices for considering the menstrual cycle effect and to demonstrate its bias in the identification of potential biomarkers. From the 35 studies meeting the criteria, 31.43% did not register the menstrual cycle phase. We analysed the menstrual cycle effect in 11 papers (including 12 studies) from Gene Expression Omnibus: t…
Transcriptional Rewiring, Adaptation, and the Role of Gene Duplication in the Metabolism of Ethanol of Saccharomyces cerevisiae
2020
Ethanol is the main by-product of yeast sugar fermentation that affects microbial growth parameters, being considered a dual molecule, a nutrient and a stressor. Previous works demonstrated that the budding yeast arose after an ancient hybridization process resulted in a tier of duplicated genes within its genome, many of them with implications in this ethanol “produce-accumulate-consume” strategy. The evolutionary link between ethanol production, consumption, and tolerance versus ploidy and stability of the hybrids is an ongoing debatable issue. The implication of ancestral duplicates in this metabolic rewiring, and how these duplicates differ transcriptionally, remains unsolved. Here, we …
Characterizing Cavities in Model Inclusion Fullerenes: A Comparative Study
2001
Abstract: The fullerene-82 cavity is selected as a model system in order to test several methods for characterizing inclusion molecules. The methods are based on different technical foundations such as a square and triangular tessellation of the molecular surface, spherical tessellation of the molecular surface, numerical integration of the atomic volumes and surfaces, triangular tessellation of the molecular surface, and cubic lattice approach to the molecular volume. Accurate measures of the molecular volume and surface area have been performed with the pseudorandom Monte Carlo (MCVS) and uniform Monte Carlo (UMCVS) methods. These calculations serve as a reference for the rest of the meth…
Relationship between authors’ keywords in journal papers and indexing terms in databases ISOC, IME and ICYT
2005
The keywords provided by authors in their scientific articles and the descriptors assigned to those articles in various databases are analysed to find out the role played by these keywords during the indexing process. In order to do that, 108 periodical publications proportionally distributed between Social Sciences and Humanities (36 journals), Science and Technology (36) and Medical and Health Sciences (36) were selected. Ten articles were selected from each of the 108 journals from different years, so that we worked altogether on 1080 articles meeting two conditions: including keywords and being indexed in the databases ISOC, ICYT or IME. Then, we proceeded to draw a comparison between t…
Información directa al paciente de medicamentos de prescripción médica: estudio de opinión entre prescriptores y pacientes
2018
En 2002, el Parlamento Europeo rechazó abrumadoramente la propuesta de la Dirección de la Comisión Europea General de Empresas e Industria para autorizar la publicidad directa de los medicamentos con receta directamente al público (PDC). Sin embargo, la presión de la industria farmacéutica puede equiparar la normativa en Europa con lo que sucede en EE. UU. y Nueva Zelanda, donde la propia industria farmacéutica es capaz de proporcionar información de medicamentos bajo prescripción utilizando los canales por los que habitualmente se suministra publicidad general (prensa, TV, radio, internet, etc.). El presente estudio tiene como objetivo principal conocer si hay diferencias de opinión entre …
La emergencia viral como consecuencia de la interacción entre las variabilidades genéticas del virus y huésped
2015
La variabilidad genética en las poblaciones de huéspedes para la susceptibilidad al patógeno es esencial para la propagación de un virus emergente. Los modelos matemáticos predicen que la tasa de difusión del patógeno se frena a medida que aumenta la frecuencia y la diversidad de alelos de resistencia en la población huésped148,230. Sin embargo, las pruebas experimentales de esta hipótesis son escasas. Por ese motivo, este trabajo aborda la cuestión de cuánta heterogeneidad genética del huésped es necesaria para el cambio del destino evolutivo del virus. El modelo de patosistema experimental utilizado en este trabajo está compuesto por el Virus del grabado del tabaco (TEV), aislado At17b (T…
Lisämateriaali artikkeliin "Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent".
2022
Electronic material for Kesäniemi J, Jernfors T, Lavrinienko A, Kivisaari K, Kiljunen M, Mappes T & Watts PC. 2019. Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent. Molecular Ecology 28: 4620–4635. Contains transcriptome annotation data and output of differential expression and gene ontology enrichment analyses. Parts of the dataset originally published in DRYAD (https://doi.org/10.5061/dryad.j3c6r69).
Variability of the human gut microbiota in space, time, and associated with the irritable bowel syndrome
2013
Esta tesis doctoral se centra en el estudio de una de las comunidades microbianas más complejas y de mayor interés biomédico: la microbiota asociada al intestino distal de humanos. El objetivo principal ha sido estudiar las alteraciones potenciales de la microbiota intestinal en relación con el síndrome del intestino irritable (SII), el desorden funcional del tracto gastrointestinal más común en sociedades occidentales. Nuestra aproximación forma parte de una visión actual sobre las relaciones entre microorganismos y hospedadores que trasciende la clásica y estrecha mirada sobre patógenos concretos y enfermedades infecciosas y la desplaza hacia una concepción más de conjunto, que valora los…
QUALITY ASSURANCE IN PREUNIVERSITY ROMANIAN EDUCATION WITHIN THE EU INTEGRATION
2013
The Purpose of this work is to show the importance of quality assurance in Romanian pre-university education. The research objectives are:identification of quality performance descriptors of Romanian pre-university education,identify performance improvement indicators as Research methodology is documented by capturing the qualitative analysis. The results of the research led to the understanding of the extent to which quality Romanian preuniversity education management is, compared to Europe.