Search results for "Criteri"
showing 10 items of 807 documents
French Endocrine Society Guidance on endocrine side effects of immunotherapy.
2018
The management of cancer patients has changed due to the considerably more frequent use of immune checkpoint inhibitors (ICPIs). However, the use of ICPI has a risk of side effects, particularly endocrine toxicity. Since the indications for ICPI are constantly expanding due to their efficacy, it is important that endocrinologists and oncologists know how to look for this type of toxicity and how to treat it when it arises. In view of this, the French Endocrine Society initiated the formulation of a consensus document on ICPI-related endocrine toxicity. In this paper, we will introduce data on the general pathophysiology of endocrine toxicity, and we will then outline expert opinion focusing…
Imaging standardisation in metastatic colorectal cancer: a joint EORTC-ESOI-ESGAR expert consensus recommendation
2022
Background: Treatment monitoring in metastatic colorectal cancer (mCRC) relies on imaging to evaluate the tumor burden. Response Evaluation Criteria in Solid Tumors (RECIST) provide a framework on reporting and interpretation of imaging findings yet offer no guidance on a standardized imaging protocol tailored to mCRC patients. Imaging protocol heterogeneity remains a challenge for the reproducibility of conventional imaging endpoints and is an obstacle for research on novel imaging endpoints. Patients and methods: Acknowledging the recently highlighted potential of radiomics and artificial intelligence (AI) tools as decision support for patient care in mCRC, a multidisciplinary, internatio…
ANOVA-MOP: ANOVA Decomposition for Multiobjective Optimization
2018
Real-world optimization problems may involve a number of computationally expensive functions with a large number of input variables. Metamodel-based optimization methods can reduce the computational costs of evaluating expensive functions, but this does not reduce the dimension of the search domain nor mitigate the curse of dimensionality effects. The dimension of the search domain can be reduced by functional anova decomposition involving Sobol' sensitivity indices. This approach allows one to rank decision variables according to their impact on the objective function values. On the basis of the sparsity of effects principle, typically only a small number of decision variables significantl…
NAUTILUS framework : towards trade-off-free interaction in multiobjective optimization
2016
In this paper, we present a framework of different interactive NAUTILUS methods for multiobjective optimization. In interactive methods, the decision maker iteratively sees solution alternatives and provides one’s preferences in order to find the most preferred solution. We question the widely used setting that the solutions shown to the decision maker should all be Pareto optimal which implies that improvement in any objective function necessitates allowing impairment in some others. Instead, in NAUTILUS we enable the decision maker to make a free search without having to trade-off by starting from an inferior solution and iteratively approaching the Pareto optimal set by allowing all obje…
A solution process for simulation-based multiobjective design optimization with an application in the paper industry
2014
In this paper, we address some computational challenges arising in complex simulation-based design optimization problems. High computational cost, black-box formulation and stochasticity are some of the challenges related to optimization of design problems involving the simulation of complex mathematical models. Solving becomes even more challenging in case of multiple conflicting objectives that must be optimized simultaneously. In such cases, application of multiobjective optimization methods is necessary in order to gain an understanding of which design offers the best possible trade-off. We apply a three-stage solution process to meet the challenges mentioned above. As our case study, w…
Interactive Nonlinear Multiobjective Optimization Methods
2016
An overview of interactive methods for solving nonlinear multiobjective optimization problems is given. In interactive methods, the decision maker progressively provides preference information so that the most satisfactory Pareto optimal solution can be found for her or his. The basic features of several methods are introduced and some theoretical results are provided. In addition, references to modifications and applications as well as to other methods are indicated. As the role of the decision maker is very important in interactive methods, methods presented are classified according to the type of preference information that the decision maker is assumed to provide. peerReviewed
A New Hybrid Mutation Operator for Multiobjective Optimization with Differential Evolution
2011
Differential evolution has become one of the most widely used evolution- ary algorithms in multiobjective optimization. Its linear mutation operator is a sim- ple and powerful mechanism to generate trial vectors. However, the performance of the mutation operator can be improved by including a nonlinear part. In this pa- per, we propose a new hybrid mutation operator consisting of a polynomial based operator with nonlinear curve tracking capabilities and the differential evolution’s original mutation operator, to be efficiently able to handle various interdependencies between decision variables. The resulting hybrid operator is straightforward to implement and can be used within most evoluti…
Flexible Data Driven Inventory Management with Interactive Multiobjective Lot Size Optimization
2021
We study data-driven decision support and formalise a path from data to decision making. We focus on lot sizing in inventory management with stochastic demand and propose an interactive multi-objective optimisation approach. We forecast demand with a Bayesian model, which is based on sales data. After identifying relevant objectives relying on the demand model, we formulate an optimisation problem to determine lot sizes for multiple future time periods. Our approach combines different interactive multi-objective optimisation methods for finding the best balance among the objectives. For that, a decision maker with substance knowledge directs the solution process with one’s preference inform…
Multiobjective shape design in a ventilation system with a preference-driven surrogate-assisted evolutionary algorithm
2019
We formulate and solve a real-world shape design optimization problem of an air intake ventilation system in a tractor cabin by using a preference-based surrogate-assisted evolutionary multiobjective optimization algorithm. We are motivated by practical applicability and focus on two main challenges faced by practitioners in industry: 1) meaningful formulation of the optimization problem reflecting the needs of a decision maker and 2) finding a desirable solution based on a decision maker’s preferences when solving a problem with computationally expensive function evaluations. For the first challenge, we describe the procedure of modelling a component in the air intake ventilation system wi…
Projections onto the Pareto surface in multicriteria radiation therapy optimization
2015
Purpose: To eliminate or reduce the error to Pareto optimality that arises in Pareto surface navigation when the Pareto surface is approximated by a small number of plans. Methods: The authors propose to project the navigated plan onto the Pareto surface as a postprocessing step to the navigation. The projection attempts to find a Pareto optimal plan that is at least as good as or better than the initial navigated plan with respect to all objective functions. An augmented form of projection is also suggested where dose–volume histogram constraints are used to prevent that the projection causes a violation of some clinical goal. The projections were evaluated with respect to planning for int…