Search results for "Crohn’"

showing 10 items of 32 documents

HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Exper…

2021

Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have therapeutic potential in the treatment of several immune disorders, including ulcerative colitis, owing to their regenerative and immunosuppressive properties. We recently showed that MSCs engineered to overexpress hypoxia-inducible factor 1-alpha and telomerase (MSC-T-HIF) and conditioned with pro-inflammatory stimuli release EVs (EVMSC-T-HIFC) with potent immunomodulatory activity. We tested the efficacy of EVMSC-T-HIFC to repolarize M1 macrophages (Mφ1) to M2-like macrophages (Mφ2-like) by analyzing surface markers and cytokines and performing functional assays in co-culture, including efferocytosis and T-cel…

MaleCrohn’s diseasemedicine.medical_treatmentimmunomodulationMiceIntestinal mucosaCrohn DiseaseMedicineBiology (General)TelomeraseSpectroscopyCell PolarityGeneral MedicineComputer Science ApplicationsChemistryCytokinemacrophage repolarizationhypoxia-inducible factor 1-alphaCytokinesmesenchymal stromal cellsMyofibroblastGastroenterología y hepatologíaQH301-705.5CatalysisArticleInorganic ChemistryExtracellular VesiclesYoung AdultImmune systemCell AdhesionHuman Umbilical Vein Endothelial CellsAnimalsHumansPhysical and Theoretical ChemistryColitisEfferocytosisQD1-999Molecular BiologyAcute colitisbusiness.industryOrganic ChemistryMesenchymal stem cellMesenchymal Stem Cellsmedicine.diseaseHypoxia-Inducible Factor 1 alpha SubunitDisease Models AnimalTrinitrobenzenesulfonic AcidCancer researchbusiness
researchProduct

Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study

2020

Abstract Background The role of the gut microbiota in Crohn’s disease (CD) is established and fecal microbiota transplantation (FMT) is an attractive therapeutic strategy. No randomized controlled clinical trial results are available. We performed a randomized, single-blind, sham-controlled pilot trial of FMT in adults with colonic or ileo-colonic CD. Method Patients enrolled while in flare received oral corticosteroid. Once in clinical remission, patients were randomized to receive either FMT or sham transplantation during a colonoscopy. Corticosteroids were tapered and a second colonoscopy was performed at week 6. The primary endpoint was the implantation of the donor microbiota at week 6…

Microbiology (medical)AdultMaleCrohn’s diseasemedicine.medical_specialtymedicine.drug_class[SDV]Life Sciences [q-bio]ColonoscopyPilot ProjectsGut floraMicrobiologyGastroenterologySeverity of Illness Indexlcsh:Microbial ecologylaw.inventionFecal microbiota transplantation03 medical and health sciencesFeces0302 clinical medicineRandomized controlled trialCrohn DiseaselawAdrenal Cortex HormonesInternal medicinemedicineClinical endpointHumansSingle-Blind Method030304 developmental biology0303 health sciencesCrohn's diseasebiologymedicine.diagnostic_testMicrobiotaResearchRemission Inductionbiology.organism_classificationmedicine.disease3. Good healthClinical trialTransplantationCrohn's diseaseTreatment OutcomeResearch DesignRandomized controlled trialCorticosteroidlcsh:QR100-130030211 gastroenterology & hepatologyFemaleMicrobiome
researchProduct

Evaluation of Changes in Gut Microbiota in Patients with Crohn’s Disease after Anti-Tnfα Treatment: Prospective Multicenter Observational Study

2020

Background: Crohn’s disease is believed to result from the interaction between genetic susceptibility, environmental factors and gut microbiota, leading to an aberrant immune response. The objectives of this study are to evaluate the qualitative and quantitative changes in the microbiota of patients with Crohn’s disease after six months of anti-tumor-necrosis factor (anti-TNFα) (infliximab or adalimumab) treatment and to determine whether these changes lead to the recovery of normal microbiota when compared to a control group of healthy subjects. In addition, we will evaluate the potential role of the Faecalibacterium prausnitzii/Escherichia coli and Faecalibacterium prausnitzii/Clostridium…

Project ReportCrohn’s diseasemedicine.medical_specialtyanti-TNFαHealth Toxicology and MutagenesisFaecalibacterium prausnitziilcsh:MedicineDiseaseGut flora03 medical and health sciences0302 clinical medicineCrohn DiseaseInternal medicinemedicineAdalimumabEscherichia coli and Clostridium coccoides groupHumansProspective Studies030304 developmental biology0303 health sciencesCrohn's diseasebiologygut microbiotabusiness.industryFaecalibacterium prausnitziiTumor Necrosis Factor-alphalcsh:RPublic Health Environmental and Occupational Healthmedicine.diseasebiology.organism_classificationInfliximabGastrointestinal MicrobiomeDysbiosis030211 gastroenterology & hepatologyCalprotectinbusinessDysbiosismedicine.drugInternational Journal of Environmental Research and Public Health
researchProduct

Dzīves kvalitāte pacientiem ar iekaisīgo zarnu slimībām Latvijā

2017

Ievads: čūlains kolīts (ČK) un Krona slimība (KS) ir divas galvenās neizārstējamās iekaisīgu zarnu slimības (IZS), kuras bez slimībai specifiskajiem simptomiem būtiski ietekmē arī pacientu dzīves kvalitāti (DzK). Darba mērķi: Novērtēt pacientu ar IZS dzīves kvalitāti, korelāciju starp slimības gaitu un DzK, salīdzināt ČK un KS pacientu dzīves kvalitāti un noskaidrot, vai pastāv korelācija starp DzK un klīniskajiem un demogrāfiskiem rādītājiem. Materiāls un metodes: Tika atlasīti gan stacionēti, gan ambulatori pacienti, kuriem tika lūgts aizpildīt IZS anketu (IZSA), novērtējot sociālos, emocionālos u.c. aspektus, kā arī otru anketu ar vispārīgiem un demogrāfiskiem datiem. Rezultāti: Kopā pēt…

Quality of life (QOL)Crohn’s Disease (CD)Inflammatory Bowel Disease Questionnaire (IBDQ)Ulcerative Colitis (UC)Inflammatory Bowel Disease (IBD)Medicīna
researchProduct

Estudio de la prevalencia de incontinencia fecal y alteración de la calidad de vida referida a la misma en pacientes con enfermedad inflamatoria inte…

2017

RESUMEN Objetivos: Conocer la prevalencia de la incontinencia fecal (IF) en los pacientes con Enfermedad Inflamatoria Intestinal Crónica (EIIC) y analizar su impacto en la calidad de vida. Métodos: Estudio prospectivo aleatorizado, descriptivo y analítico en 726 pacientes con EIIC (Enfermedad de Crohn (EC) y Colitis Ulcerosa (CU)) pertenecientes al departamento de salud del Hospital Clínico de Valencia. Se excluyen pacientes<18 años, pacientes con colitis indeterminadas, portadores de colostomías, ileostomías, reservorios o deterioro cognitivo. Se recogen variables demográficas, características fenotípicas de su EIIC, antecedentes personales y actividad de la EIIC. Se evalúa la calidad de v…

SF-36- Cuestionario calidad de vida en generalEP- Enfermedad perianalFactores de riesgo de incontinencia fecalCU- Colitis UlcerosaEIIC- Enfermedad Inflamatoria intestinal crónicaEC- Enfermedad de CrohnHCUV- Hospital Clínico Universitario de ValenciaIF- Incontinencia fecalIBDQ-32- Intestinal bowel disease questionaireECCO- European Crohn’s and colitis organitationCuestionario de wexnerCV- Calidad de vidaFIQLS- Cuestionario de calidad de vida en la incontinencia
researchProduct

Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase

2015

Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …

WT wild typeApolipoprotein BEMSA electrophoretic mobility shift assayMPO myeloperoxidaseIκB kinaseDSS dextran sodium sulphatemTOR the mammalian target of rapamycinRT-PCR real-time polymerase chain reactionNF-κBchemistry.chemical_compound540 ChemistryApoA-I apolipoprotein A-I10038 Institute of Clinical ChemistryOriginal ResearchTNF tumor necrosis factorbiologyIBD inflammatory bowel diseaseChemistryGastroenterologyMyeloperoxidase10076 Center for Integrative Human PhysiologyMEICS murine endoscopic index of colitis severityTumor necrosis factor alphalipids (amino acids peptides and proteins)3-MA 3-methyl adenineNF-κB nuclear factor κBHDL high-density lipoproteinLC3II light chain 3 IIPBS phosphate-buffered salinep-IKK phosphorylated IκB kinase610 Medicine & healthICAM intracellular adhesion molecule246-Trinitrobenzenesulfonic acidTg transgenicmedicineAutophagyCD Crohn’s disease2715 GastroenterologyColitislcsh:RC799-869KO knockoutHepatologyApolipoprotein A-IAutophagyInflammatory Bowel DiseaseTNBS 246-trinitrobenzenesulfonic acidmedicine.diseaseMolecular biologyIL interleukinsiRNA small interfering RNAPI-3 phosphatidylinositol-3Immunologybiology.protein2721 Hepatologylcsh:Diseases of the digestive system. GastroenterologyPFA paraformaldehydeLipoproteinDAPI 4′6-diamidino-2-phenylindoleCMGH Cellular and Molecular Gastroenterology and Hepatology
researchProduct

Prevalence of endodontic infection in patients with Crohn ́s disease and ulcerative colitis

2021

[Background] Previous studies have linked apical periodontitis (AP) to inflammatory bowel disease (IBD). The aim of this study was to compare the prevalence of AP and root canal treatment (RCT) in patients with ulcerative colitis (UC) and Crohn ́s disease (CD).

burning mouth syndromeCrohn’s diseasemedicine.medical_specialtyMultivariate analysisRoot canalefficacyDiseaseLogistic regressionInflammatory bowel diseaseGastroenterologyInflammatory bowel disease03 medical and health sciences0302 clinical medicinesystematic reviewCrohn DiseaseToot canal treatmentApical periodontitisInternal medicinePrevalencemedicineHumansGeneral DentistryUNESCO:CIENCIAS MÉDICASPeriodontitisCrohn's diseaseOral Medicine and Pathologybusiness.industryResearch030206 dentistrylow level laser therapymedicine.diseaseUlcerative colitisdigestive system diseasesRoot Canal TherapyCross-Sectional Studiesmedicine.anatomical_structureOtorhinolaryngologyUlcerative colitisColitis UlcerativeSurgerybusinessPeriapical Periodontitis
researchProduct

Vulvar involvement in pediatric Crohn’s disease: a systematic review

2018

Purpose: The aim of the study is to report a systematic review (from 2000 to 2017) of all pediatric cases of vulvar Crohn’s disease (VCD) and to highlight the key-points for a correct diagnosis and management of this rare condition. Methods: An electronic search using the Pubmed/Medline, Scopus, EMBASE, Cochrane database and Google Scholar database was performed according to PRISMA guidelines. Results: Twenty pediatric studies and 22 cases of VCD were included for analysis. All the articles reported a single case, except two articles where two cases, respectively, are described. Clinical vulvar examination showed the following main manifestations: vulvar erythema (9/22 cases, 40.9%), vulv…

endocrine systemmedicine.medical_specialtyPediatric Crohn's diseaseVulvar edemaAdministration TopicalAdministration OralDiseasePerineumGastroenterologyVulvaPediatric Crohn’s disease030207 dermatology & venereal diseases03 medical and health sciencesPediatric Crohn’s disease0302 clinical medicineCrohn DiseaseObstetrics and gynaecologyMetronidazoleInternal medicineEdemaHumansMedicineVulvar diseaseChildbusiness.industryObstetrics and GynecologyGeneral MedicineDermatologyExtra-intestinal Crohn’s disease030220 oncology & carcinogenesisVulvar edemaFemaleVulvar DiseasesExtra-intestinal Crohn’s diseasebusinessExtra-intestinal Crohn’s disease; Pediatric Crohn’s disease; Vulvar disease; Vulvar edema; Obstetrics and Gynecology
researchProduct

Telemedicine Is an Effective Tool to Monitor Disease Activity in IBD Patients in the COVID-19 Era: A Single Centre Experience Based on Objective Data

2022

Background: The COVID-19 outbreak has led IBD clinics to adopt a remote monitoring approach in order to guarantee an adequate follow-up of patients with inflammatory bowel disease (IBD) and ensure the rules of social distancing. Aim: The aim of the study was to perform a survey on IBD patients who underwent remote monitoring in our tertiary referral center, to assess adherence, patients&rsquo; perceptions and satisfaction, and finally their opinions for future monitoring. Furthermore, we evaluated changes in disease activity and Quality of Life (QoL) using validated questionnaires. Methods: Consecutive patients with IBD scheduled for follow-up visits were switched to remote monitoring throu…

inflammatory bowel disease; COVID-19; telemedicine; ulcerative colitis; Crohn’s DiseaseHepatologyinflammatory bowel diseaseGastroenterologyCrohn's Disease.COVID-19telemedicineulcerative coliti
researchProduct

Cytomegalovirus Pneumonia: A Possible Cause of Death in Patients With Crohn's Disease

2013

.

medicine.medical_specialtyCrohn's diseaseGastrointestinal agentCytomegalovirus pneumoniaHepatologyCrohn diseasebusiness.industryGastroenterologymedicine.diseaseCytomegalovirus Cytomegalovirus Infections ColitisGastroenterologyCytomegalovirus pneumonia Crohn’s diseaseAntibodies monoclonalInternal medicinemedicineIn patientbusinessCause of deathAmerican Journal of Gastroenterology
researchProduct