Search results for "Cross-Over Studies"
showing 10 items of 212 documents
Rapid Self-Hypnosis: A New Self-Hypnosis Method and Its Comparison with the Hypnotic Induction Profile (HIP)
2001
Despite its clinical importance, there are few systematic studies on the application of self-hypnosis. Rapid Self-Hypnosis (RSH) was created to provide a new procedure that is easy, comfortable, fosters alertness, and can be done covertly in everyday life. We present it as an alternative to the self-hypnosis version of the Hypnosis Induction Profile (HIP). Using a crossover design, we found in an experimental session that the RSH and the HIP produced comparable objective and subjective scores in the Barber Suggestibility Scale (BSS). However, as compared with the HIP, participants rated RSH as significantly more coherent, pleasant, faster and easier to learn, more likely to be used in every…
Preference between two methods of active-alert hypnosis: not all techniques are created equal.
1999
Abstract In a cross-over design (N = 80), we compared the differential liking and preference for two hypnotic techniques involving physical activity: Active-alert and waking-alert (or alert-hand) procedures. Participants expressed significantly higher liking and preference for the waking-alert as compared to the active-alert procedure. The latter technique, which also had significantly lower suggestibility scores (Cardena et al., 1998) was also associated with a significantly higher attrition rate (23%). These significant differences may be explained by the greater physical effort and difficulty associated with the active-alert technique. It seems that the waking-alert method extends the ad…
Safety and tolerability of slow-release oral morphine versus methadone in the treatment of opioid dependence
2014
Opioid substitution treatment (OST) for opioid dependence may be limited by adverse events (AEs). Increasing the range of therapeutic options optimizes outcomes and facilitates patient management. An international, multi-center, two-phase study investigated the efficacy and safety of slow-release oral morphine (SROM) versus methadone in patients receiving methadone therapy for opioid dependence. In phase 1 (two way cross-over, 11 weeks each period) patients were randomized to SROM or methadone oral solution. In phase 2 (25 weeks), patients continued treatment with SROM (group A) or switched from methadone to SROM (group B). In total, 211 out of 276 completed phase 1 and 198 entered phase 2 …
Effects of different electrical stimulation currents and phase durations on submaximal and maximum torque, efficiency, and discomfort: a randomized c…
2021
Abstract Background Neuromuscular electrical stimulation (NMES) is an important therapeutic tool for rehabilitation. However, best stimulation parameters remain to be determined. Objective To determine the influence of different electrical stimulation currents and phase durations on torque, efficiency, and discomfort. Methods Using a cross-over design, kHz frequency alternating currents (KFAC) and pulsed currents (PC) with narrow (200 µs) or wide (500 µs) phase durations were randomly applied on knee extensor muscles of healthy participants with a minimum of seven days between sessions. The NMES-evoked torque, NMES-efficiency, and discomfort (visual 0−10 cm analogue scale) were measured for…
Neomuscular fatigue to power loading using a weight-stack device fitted with or without additional rubber band resistance
2014
The addition of a rubber band (RB) to traditional weight-based resistance may be beneficial regarding the deceleration phase common during explosive power actions with light weights. This would lead to greater force and muscle activity during the latter part of the movement, but this may influence the distribution of neuromuscular fatigue. Fifteen men performed 2 knee extension power loadings (5 × 5 × 40% of 1 repetition maximum [1RM]) using a typical weight-stack device without (WS) and with the addition of a RB (WS + RB) in a crossover design. Concentric contractions were performed as fast as possible, and analyzed for torque, velocity, power, and vastus lateralis and medialis surface ele…
Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application
1994
Pharmacokinetics and bioavailability of benperidol were determined in 13 schizophrenic patients after acute administration of 6 mg benperidol as an intravenous (i.v.) bolus injection, orally as liquid, and orally as tablets using a partially randomized cross-over design. Drug plasma levels were determined by high performance liquid chromatography with electrochemical detection and subjected to model independent pharmacokinetic analyses. After i.v. dosing the geometric means (mean-g) were 3.2 min for the distribution half-life, 5.80 h for the elimination half-life (t1/2 beta), 4.21 l/kg for the distribution volume, 7.50 h for the mean residence time (MRT), and 0.50 l/(h*kg) for the clearance…
Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: a double blinded cro…
2017
Background Using a double-blinded randomized crossover design, this study aimed to evaluate acute postoperative pain management, swelling and trismus in 46 volunteers undergoing extractions of the two lower third molars, in similar positions, at two different appointments who consumed a tablet of either NE (naproxen 500 mg + esomepraz ole 20 mg) or only naproxen (500 mg) every 12 hours for 4 days. Material and Methods Parameters were analyzed: self-reported pain intensity using a visual analog scale (VAS) pre- and postoperative mouth opening; incidence, type and severity of adverse reactions; total quantity consumed of rescue medication; and pre- and postoperative swelling. Results Female v…
Performance, balance and posture variations with Occlusal Splint and Taopatch® devices: a retrospettive cross-over study
2021
Background The aim of the study was to evaluate how muscular performances, balance and posture were influenced applying Occlusal Splints and Taopatch® 8 (Tao Technologies Srls, Cittadella, Padua, Italy) devices in athletes. Methods Eighteen athletes, 7 females and 11 males, with an average age of 23.8 years, were included. Two devices were used: 1) a customized soft occlusal splint to be applied to the lower ach; 2) nanotechnological devices based on carbon nanotubules and quantum dots (Taopatch®) positioned on C7 and xiphoid process. Four functional tests were performed: surface electromyography (sEMG), kinesiography, the squat jump and counter movement jump and handgrip test. The tests we…
Effects of L-Carnitine L-Tartrate Supplementation on Muscle Oxygenation Responses to Resistance Exercise
2008
Previous research has shown that L-carnitine L-tartrate (LCLT) supplementation beneficially affects markers of hypoxic stress following resistance exercise. However, the mechanism of this response is unclear. Therefore, the primary purpose of this study was to determine the effects of LCLT supplementation on muscle tissue oxygenation during and after multiple sets of squat exercise. Nine healthy, previously resistance-trained men (25.2 +/- 6.years, 91.2 +/- 10.2 kg, 180.2 +/- 6.3 cm) ingested 2 g.d of LCLT or an identical placebo for 23 days in a randomized, balanced, crossover, double-blind, placebo-controlled, repeated-measures study design. On day 21, forearm muscle oxygenation was measu…
Maintenance treatment for opioid dependence with slow‐release oral morphine: a randomized cross‐over, non‐inferiority study versus methadone
2012
Aims To compare the efficacy of slow-release oral morphine (SROM) and methadone as maintenance medication for opioid dependence in patients previously treated with methadone. Design Prospective, multiple-dose, open label, randomized, non-inferiority, cross-over study over two 11-week periods. Methadone treatment was switched to SROM with flexible dosing and vice versa according to period and sequence of treatment. Setting Fourteen out-patient addiction treatment centres in Switzerland and Germany. Participants Adults with opioid dependence in methadone maintenance programmes (dose ≥50 mg/day) for ≥26 weeks. Measurements The efficacy end-point was the proportion of heroin-positive urine samp…