Search results for "Crypt"
showing 10 items of 1111 documents
Exploiting Cryo-EM Structural Information and All-Atom Simulations To Decrypt the Molecular Mechanism of Splicing Modulators.
2019
Splicing modulators (SMs) pladienolides, herboxidienes, and spliceostatins exert their antitumor activity by altering the ability of SF3B1 and PHF5A proteins, components of SF3b splicing factor, to recognize distinct intron branching point sequences, thus finely calibrating constitutive/alternative/aberrant splicing of pre-mRNA. Here, by exploiting structural information obtained from cryo-EM data, and by performing multiple μs-long all-atom simulations of SF3b in apo form and in complex with selected SMs, we disclose how these latter seep into the narrow slit at the SF3B1/PHF5A protein interface. This locks the intrinsic open/closed conformational transitions of SFB1's solenoidal structure…
Structural effects of macrocyclic compounds and their partition in sodium dodecylsulphate aqueous solutions
2003
The partition of 1,4,7,10,13,16-esaoxacyclooctadecane (18C6), 4,7,13,16-tetraoxa-1,10-diazacyclooctadecane (2.2), 2,5,8,11,14,17-esaoxabicyclo[16.4.0]dicosane (B18C6) and 2,5,8,15,18,21-esoxatricyclo[20.4.0.09.14]esacosane (Cy218C6) in sodium dodecyl sulfate (SDS) aqueous solutions and their effect on the structure of surfactant aggregates has been investigated by small-angle neutron scattering. Results from data analysis have shown that by increasing macrocycle concentration the SDS micelles dimensions reduce for all systems investigated. At the same time information on macrocycles partition between the micellar and the continuous phase have been obtained. It was found that an appreciable …
Kinetic control in the chiral recognition of three-bladed propellers
2010
The ion pair of the stereolabile C(3)-symmetric, i(+)o proton complex [1H](+) of diaza-macropentacycle 1 and the configurationally stable Delta-TRISPHAT ([Delta-3](-)) anion exists in the form of two diastereomers, namely, [Delta-(1.H)][Delta-3] and [Lambda-(1.H)][Delta-3], the ratio of which, in terms of diastereomeric excess (de) decreases in the order [D(8)]THF (28%)CD(2)Cl(2) (22%)CDCl(3) (20%)[D(8)]toluene (16%)C(6)D(6) (7%)[D(6)]acetone (0%) at thermodynamic equilibrium. Except in the case of [D(6)]acetone, the latter is reached after a period of time that increases from 1 h ([D(8)]THF) to 24 h (CDCl(3)). Moreover, the initial value of the de of [1.H][Delta-3] in CDCl(3), before the t…
Paternal effects on functional gender account for cryptic dioecy in a perennial plant.
2004
7 páginas, 3 figuras, 1 tabla.
Molecular data attest to the occurrence of autochthonous Daphnia pulex (Crustacea, Branchiopoda) populations in Sicily, Italy
2021
Biological invasions are known to be among the most important threats to the long-term conservation of native biota, and their effects might be even more difficult to contrast when they are cryptic, i.e., when the non-native invaders cannot be easily recognised based on morphology, and can thus be confused with native taxa. Such cryptic invasions are known to widely occur in the cladoceran genus Daphnia O.F. Müller, 1785, so that the actual distribution and status of most species and lineages need to be checked with a genetic approach. In the frame of this work, we investigated if the Sicilian populations of D. (Daphnia) pulex Leydig, 1860 belonged to the allochthonous North American lineag…
Synthesis of (-)-Cryptopleurine by Combining Gold(I) Catalysis with a Free Radical Cyclization
2015
(R)-(–)-Cryptopleurine, a highly cytotoxic alkaloid found in Cryptocarya and Boehmeria species, was synthesized in high optical purity using a gold(I)-NHC catalyzed cyclization of an unsymmetrical phenanthrene precursor combined with a free radical cyclization to achieve closure of the C-ring.
A behavioural finance explanation of speculative bubbles: evidence from the bitcoin price development
2019
In 2008 a group of programmers, alias Satoshi Nakamoto, introduced bitcoin. Bitcoin is a cryptocurrency or virtual money derived from mathematical cryptography and is conceived as an alternative to government authorised currency. The founder anticipated, through bitcoin’s construction and his digital mining processes, that bitcoin prices would be relatively stable. However, the recent bitcoin price decline proves that bitcoin is extraordinarily volatile and is not that stable as hoped. Although some scientists have already shown that the fundamental value of bitcoin is zero, the price of bitcoin has reached over 19.000$ in December 2018. Since then, bitcoin prices dropped nearly 70% from th…
Next-Day Bitcoin Price Forecast
2019
This study analyzes forecasts of Bitcoin price using the autoregressive integrated moving average (ARIMA) and neural network autoregression (NNAR) models. Employing the static forecast approach, we forecast next-day Bitcoin price both with and without re-estimation of the forecast model for each step. For cross-validation of forecast results, we consider two different training and test samples. In the first training-sample, NNAR performs better than ARIMA, while ARIMA outperforms NNAR in the second training-sample. Additionally, ARIMA with model re-estimation at each step outperforms NNAR in the two test-sample forecast periods. The Diebold Mariano test confirms the superiority of forecast …
Virtual Currency: New Step in Monetary Development
2016
Abstract Money is perhaps the best recognized and at the same time less understood figure of economy. During the evolution of a monetary science starting from the eighteenth century and fundamental works on such questions as true nature and main functions of money, the approach and theories about monetary science have changed significantly up to date not reaching the final state. The twenty-first century can be characterized with a vast development of technologies and the increase use of the internet which significantly succeeded the development of monetary system introducing a new phenomenon - virtual currencies. While remaining rather illusive, virtual currencies have been broadly noted b…
Insufficiencies in European Union law and member state national law regarding cryptocurrency regulations and its illicit use
2022
Cryptocurrency market transactions and provided opportunities for individuals have highly increased the use of this new paradigm for pursuing illicit activities. The European Union has reacted to this situation and have started to imply certain regulations to restrict criminal activities such as tax evasion, money laundering, terrorist financing and others. The aim of this research is to recognize possible insufficiencies in directives, normative acts and proposals provided by the EU. Understanding the problems within these regulations will help in the constant development and creation of a unified legislation for cryptocurrency users within the EU, and possibly indicate a roadmap for other…