Search results for "Cue"
showing 10 items of 1330 documents
The role of noticing in prospective memory forgetting.
2007
Two experiments used autonomic reactions (i.e., skin conductance responses; SCRs) in conjunction with behavioral responses to study retrieval processes in prospective memory. SCRs were recorded while participants performed a prospective memory task embedded in an ongoing task. Stimuli that received the same behavioral response (i.e., no prospective memory response) evoked different autonomic reactions as a function of whether they were versus were not prospective cues (Experiments 1 and 2) and as a function of whether they did versus did not share perceptual or conceptual features with prospective cues (Experiment 2). To the extent that SCRs provide an index of noticing a stimulus, increase…
The Functional Role of Large-scale Brain Network Coordination in Placebo-induced Anxiolysis
2018
Abstract Anxiety reduction through mere expectation of anxiolytic treatment effects (placebo anxiolysis) has enormous clinical importance. Recent behavioral and electrophysiological data suggest that placebo anxiolysis involves reduced vigilance and enhanced internalization of attention; however, the underlying neurobiological mechanisms are not yet clear. Given the fundamental function of intrinsic connectivity networks (ICNs) in basic cognitive processes, we investigated ICN activity patterns associated with externally and internally directed mental states under the influence of an anxiolytic placebo medication. Based on recent findings, we specifically analyzed the functional role of the…
High cognitive reserve in bipolar disorders as a moderator of neurocognitive impairment
2017
BackgroundCognitive reserve (CR) reflects the capacity of the brain to endure neuropathology, minimize clinical manifestations and successfully complete cognitive tasks. The present study aims to determine whether high CR may constitute a moderator of cognitive functioning in bipolar disorder (BD).MethodsOne hundred and two patients with BD and 32 healthy controls were enrolled. All patients met DSM-IV criteria for I or II BD and were euthymic (YMRS ≤ 6 and HDRS ≤ 8) during a 6-month period. All participants were tested with a comprehensive neuropsychological battery, and a Cerebral Reserve Score (CRS) was estimated. Subjects with a CRS below the group median were classified as having low C…
Detection and distraction effects for threatening information in social phobia and change after treatment.
2007
This work examines differences in the detection and distraction by social-threatrelated information between a social phobia group (SP; N533) and a normal control group (NC; N532). The change obtained after psychological treatment is also studied for the SP group. A paper-and-pencil visual search task is used, in which the emotional valence of the ‘‘target’’ (social threat, physical threat, and neutral words) and ‘‘distractor’’ (social threat, physical threat, neutral, and nonsense words) verbal stimuli is manipulated. Results indicate that there are no differences in the detection of social-threat targets between SP and NC participants. However, the performance of SP individuals is more imp…
Cue exposure in alcohol dependent patients: preliminary evidence for different types of cue reactivity.
2000
Craving is considered to be an important phenomenon in addictive behaviours. However, there is still an unresolved debate on what craving for alcohol means, how it is best measured and which clinical and therapeutical consequences its presence or absence may imply. Cue reactivity paradigms have been developed to elicit craving under standardized experimental conditions. Here we present preliminary results characterizing alcohol-dependent patients with regard to subjective and psychophysiological aspects of exposure to alcohol-associated cues in a cue reactivity paradigm. Thirty-six patients fulfilling at least 5 criteria of alcohol dependence according to DSM-IV criteria were studied after …
Optokinetic stimulation affects temporal estimation in healthy humans
2007
The representation of time and space are closely linked in the cognitive system. Optokinetic stimulation modulates spatial attention in healthy subjects and patients with spatial neglect. In order to evaluate whether optokinetic stimulation could influence time perception, a group of healthy subjects performed "time-comparison" tasks of sub- and supra-second intervals before and after leftward or rightward optokinetic stimulation. Subjective time perception was biased by the direction of optokinetic stimulation. Rightward optokinetic stimulation induced an overestimation of time perception compared with baseline and leftward optokinetic stimulation. These results indicate a directional bias…
Pseudoneglect in schizophrenia: A line bisection study with cueing
2007
Numerous authors have reported the existence of lateralised abnormalities towards the right side in patients with schizophrenia.In the present study, a manual line bisection task was used to assess the existence of a visuospatial bias in patients with schizophrenia as compared to healthy subjects and left unilateral neglect patients. In addition, we used a local cueing paradigm (consisting of a number placed on the right, on the left, or at both ends of the line).Healthy subjects showed a leftwards trend in the "no cue" condition (known as pseudoneglect) and neglect patients showed a right bias in all cue conditions. In contrast, patients with schizophrenia placed their manual estimation of…
Detached and distracted: ERP correlates of altered attentional function in depersonalisation.
2018
Abstract Depersonalisation (DP) is a psychological condition marked by feelings of disembodiment. In everyday life, it is frequently associated with concentration problems. The present study used visual event-related potentials (ERPs) in a Posner-type spatial cueing task with valid, invalid and spatially neutral cues to delineate the potential neurophysiological correlates of these concentration problems. Altered attentional functioning at early, sensory stages was found in DP patients but not in anxiety- and depression-matched psychosomatic patients without DP. Specifically, DP was associated with decreased suppression of stimuli at unattended locations, shown as absent processing costs fo…
Trait anxiety and autonomic indicators of the processing of threatening information: a cued S1-S2 paradigm.
2004
Abstract The aim of this study was to use autonomic parameters in a cued S1–S2 task to examine associations between the processing of threatening information and trait anxiety in normal individuals. Forty-six student volunteers were designated high- or low-anxious due to pre-defined cutoff scores on the STAI. A cued S1–S2 task was presented in which the type of warning signal (S1) was consistently related to either threatening or non-threatening pictures (S2). Ten threat and 10 non-threat pictures were randomly presented. Heart rate and electrodermal activity were recorded in the time interval between S1 and S2. Results indicated deeper heart rate decelerations on threatening trials in high…
Effects of post-extinction l-DOPA administration on the spontaneous recovery and reinstatement of fear in a human fMRI study
2015
Relapse is a pertinent problem in the treatment of anxiety disorders. In the laboratory, relapse is modeled as return of conditioned fear responses after successful fear extinction and is explained by insufficient retrieval and/or expression of the fear-inhibitory extinction memory that is generated during extinction learning. We have shown in mice and humans that return of fear can be prevented by administration of a single dose of the dopamine precursor l-3,4-dihydroxyphenylalanine (l-DOPA) immediately after extinction. In mice, this effect could be attributed to an enhancement of extinction memory consolidation. In our human study, we could not exclude that l-DOPA might have acted by int…