Search results for "Culturali"
showing 10 items of 2081 documents
Cholesterol facilitates interactions between α‐synuclein oligomers and charge‐neutral membranes
2015
AbstractOligomeric species formed during α-synuclein fibrillation are suggested to be membrane-disrupting agents, and have been associated with cytotoxicity in Parkinson’s disease. The majority of studies, however, have revealed that the effect of α-synuclein oligomers is only noticeable on systems composed of anionic lipids, while the more physiologically relevant zwitterionic lipids remain intact. We present experimental evidence for significant morphological changes in zwitterionic membranes containing cholesterol, induced by α-synuclein oligomers. Depending on the lipid composition, model membranes are either unperturbed, disrupt, or undergo dramatic morphological changes and segregate …
Secondary nucleation and accessible surface in insulin amyloid fibril formation.
2008
At low pH insulin is highly prone to self-assembly into amyloid fibrils. The process has been proposed to be affected by the existence of secondary nucleation pathways, in which already formed fibrils are able to catalyze the formation of new fibrils. In this work, we studied the fibrillation process of human insulin in a wide range of protein concentrations. Thioflavin T fluorescence was used for its ability to selectively detect amyloid fibrils, by mechanisms that involve the interaction between the dye and the accessible surface of the fibrils. Our results show that the rate of fibrillation and the Thioflavin T fluorescence intensity saturate at high protein concentration and that, surpr…
Multiple aggregation mechanism in Abeta(1-40) fibril formation
2011
A general characteristic of aggregation is the multiple interaction and cross-feedback among distinct mechanisms occurring at different hierarchical levels. The comprehension of the different species interconversion during aggregation is very important since emerging evidences indicate intermediate oligomeric aggregates as primary toxic species. In this context, Aβ amyloid peptide provides a challenging model for studying aggregation phenomena both for the complexity of its association process and for the direct implications in Alzheimer’s Disease. Indeed, aggregates growth conditions strongly affect their final morphology and their molecular structure as well as the time evolution of aggre…
Corrigendum to “Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites” [J. Colloid Interface Sci. 606…
2023
Analisi chimiche su un’antica veste infantile del XVII secolo
2012
"L'albero Falcone" e i suoi epigoni. La propagazione vegetale della memoria antimafia
2021
Le stragi di Capaci e via D’Amelio segnano un punto di svolta nel linguaggio con cui i movimenti antimafia costruiscono la memoria pubblica della violenza mafiosa. Uno dei tratti salienti di questa svolta è la proliferazione di luoghi di memoria che ruotano intorno a figure arboree. Il capostipite di questa genealogia è l’albero Falcone, noto come punto di raccolta per le manifestazioni del 23 maggio, la giornata della legalità. Nel corso degli anni ’90, il modello memoriale costruito intorno all’albero si sviluppa e si diffonde, mentre sono sempre già frequenti le piantumazioni di alberi in memoria delle vittime della mafia. L’articolo cerca di esplicitare le forme semiotiche soggiacenti a…
Fetid odors in Caralluma europaea (Guss.) N.E.Br. (Apocynaceae-Asclepiadoideae): a chemical characterization
2008
Recovering bronze metallurgy from archaeological artefacts for the production of reference materials in conservation science
2007
The production of reference Cu-based alloys is the first step of an original experimental protocol to be used in the field of conservation and restoration of metal artefacts. The production of these synthetic alloys has a double value. They can be used both as suitable substitutes of unique archaeological pieces for testing new materials and methods for conservation, and as guidelines for contemporary metal production. We report on a research activity focused on the recovery of the ancient production techniques from the investigation of archaeological copper-based artefacts. The chemical, physical and metallurgical characterization of several Cu-based artefacts, found in different Italian a…
La crisi vista da un archeologo. Alcune considerazioni sulla situazione attuale dei beni culturali
2015
Il contributo esamina la situazione dell'archeologia siciliana negli anni della crisi, non solo dal punto di vista dell'assenza di adeguati finanziamenti, quanto dal punto di vista della politica di tutela e valorizzazione dei beni culturali e dell'investimento nella formazione. Il punto di svolta in negativo è individuato nella legge 40 del 2000 che abolì i ruoli tecnici nell'amministrazione dei beni culturali. Perché dai beni culturali si abbia un ritorno economico è necessario investire in maniera sinergica sul beni culturali stessi, sulle infrastrutture e sulla promozione del turismo.
L’Archeologia tra formazione e pratica: il ruolo dell’Università in Sicilia
2014
The relationship between university and political and social institutions in Sicily has undergone a deep transformation since the end of the '80s. Before that period, university, as a teaching and research structure, was deeply linked with political institutions dealing with the management and preservation of cultural heritage; these institutions, on the other hand, offered the main chances of employment for graduates in humanities and archaeology. After that period, university and politic have undertaken instead, completely different ways, especially in the field of cultural heritage, due to a different economic context and a wider ideological change. The role of the university as a place …