Search results for "Cyclin"
showing 10 items of 1021 documents
High-gradient accelerating structure studies and their application in hadrontherapy
2013
198 páginas. Tesis doctoral del Departamento de Física Atómica, Molecular y Nuclear, de la Universidad de Valencia.
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.
2003
International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …
Strawberry fields forever: that is, how many grams of plastics are used to grow a strawberry?
2019
In the agricultural sector, plastic is one of the most important tools for improving the managerial and economic performance of companies. The horticultural production under protected cultivation, in particular, makes abundant use of plastic polymers. Polymers that mostly turn into waste. This study aims to identify the main characteristics and factors affecting the decision of farmers operating in the strawberry production sector to recycle the plastic material used on-farm and quantify the plastic used in relation to the different types of materials used. Data come from one of the Italian most specialized areas in the strawberry sector, Marsala. Main findings show that behind a typical 25…
About_Change
2022
Il contributo raccoglie i rapporti epilogativi (Research Report) di una specifica ricerca condotta sulla tecnologia come scienza applicata al patrimonio dell’esistente oltre le good practices, al di fuori di nicchie elitarie poco rappresentative della comune produzione edilizia. Queste, ora, hanno bisogno di un approccio tecnologicamente flessibile, innestato sul consenso e sulla partecipazione evolutiva del già fatto e dal potersi ancora fare (Germanà, 2008). Ci riferiamo alla tecnologia edilizia come scienza del costruire capace di innescare nuovi percorsi del fare inerenti ai processi di trasformazione, completamento e rigenerazione dell’esistente; da ricerche ‘sensibili’ a nuove qualità…
On the degree of binder activity of reclaimed asphalt and degree of blending with recycling agents
2020
It is common practice to assume full blending of the aged binder of reclaimed asphalt (RA) within the design of new asphalt mixtures. Although being practical, this assumption has often led designers to asphalt mixtures lacking binder. Hence, going towards recycled asphalt mixtures (RAM) there is a need to have a better understanding of the blending phenomena, to have a general agreement on terminology and finally adapting RA classification and mix design procedures accordingly. This manuscript aims at being both a reference and stimulus for the scientific community to work in this direction and on this basis provides a nomenclature and a theoretical framework of the blending phenomena. The…
Effects of Chinese youth consumer recycling behavior decisions : application of TPB theory to beverage container recycling system adoption
2016
Increasing municipal waste is a challenge that China is facing during decades, especially along with the economic growth. Although recycling is apparently an efficient method to deal with the problem, 2% of solid waste recycled in China revealed there is barrier in the path. The recycling system is developing in China by government and companies, hence understanding and predicting Chinese consumers’ acceptance of the system is necessary. This research is aim to understand the Chinese youth consumers’ recycling behavior through the view on beverage container recycling behavior. Hypothesizes in this study is proposed according to the theoretical framework of the TPB, which is attitude toward …
Re-Urban | De-frag. Progetti per trasformare la circonvallazione di Palermo
2014
This article presents a short survey of contemporary approaches to re-cycling, up-cycling and recovering urban freeways. Further, it introduces the assumptions and some initial descriptions of cases study of the Degree studio "In-FRA. Architettura e infrastruttura nella città contemporanea", that Z. Tesoriere conducts since 2013 at the University of Palermo. The studio focuses on how enhancing architectural conditions of urban freeways in contemporary urban realm, with particular attention to the circonvallazione of Palermo.
RECYCLING AND THERMOMECHANICAL DEGRADATION OF POLYETHYLENE/ORGANO-MODIFIED CLAY NANOCOMPOSITES
2013
The future of bottle recycling in the United States of America
2012
In this Master’s thesis, the future of bottle recycling in the United States of America will be examined through interest, incentive and an infrastructure (iii) model. One of the American ways to recycle bottles, namely, the Dream Machine initiative, will be compared to the Finnish bottle recycling system. It will shed light through surveys done from Finnish high school students and randomly selected Americans about bottle recycling behaviour. In addition, two supportive surveys were administered to bring validity about the possible behavioral change through properly implemented recycling systems. The main conclusion is that through a proper implementation of a bottle recycling system, Amer…