Search results for "Cyclin"

Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor

2020

Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …

Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia

2017

ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…

Spatial Succession for Degradation of Solid Multicomponent Food Waste and Purification of Toxic Leachate with the Obtaining of Biohydrogen and Biomet…

2022

A huge amount of organic waste is generated annually around the globe. The main sources of solid and liquid organic waste are municipalities and canning and food industries. Most of it is disposed of in an environmentally unfriendly way since none of the modern recycling technologies can cope with such immense volumes of waste. Microbiological and biotechnological approaches are extremely promising for solving this environmental problem. Moreover, organic waste can serve as the substrate to obtain alternative energy, such as biohydrogen (H2) and biomethane (CH4). This work aimed to design and test new technology for the degradation of food waste, coupled with biohydrogen and biomethane prod…

Mercury concentration and speciation in volcanic aquifers: measurements in Italy and Guadeloupe (Lesser Antilles)

2008

Pyöräilyn hyötysuhteiden yhteyksiä

2017

Pyöräilytyössä hyötysuhdetta (ulkoisen polkemistyön suhdetta kokonaisenergiankulutukseen)on helppo tutkia ja tällaiseen metaboliseen tehokkuuteen onkin määritelty monia erilaisia mittareita. Fysiologisten ja biomekaanisten muuttujien vaikutuksia näihin eri tavoin määritettyihin hyötysuhteisiin tunnetaan hyvinkin, mutta tätä ennen ei olla juurikaan tutkittu mitkä ovat eri tavoin määriteltyjen hyötysuhteiden keskinäiset suhteet. Tutkimukseen osallistui 14 perustervettä fyysisesti aktiivista 31 ± 6 vuotiasta mies- (n = 12)ja naistutkittavaa (n = 2). Tutkittaville laskettiin kuusi erilaista metabolisen tehokkuuden arvoa: vakioteholla (150 W) kokonais- ja nettohyötysuhde, kaksi työhyötysuhdetta …

A Green Approach for Recycling Compact Discs

2023

Compact discs (CDs) and digital versatile discs (DVDs) are mainly made by polycarbonate disc, a thin layer of aluminum or silver, a thin layer of a coating and a thin layer of a label of paper or PET. The recycling of these discs is difficult due to the removal of these non-polymeric layers and to our best knowledge, no industrial plants have been resent for their recycling. In this work, we propose a facile way to remove the non-polymeric layers and investigate the effect of the repetitive extrusion process on the processability and on the mechanical properties of the recycled polycarbonate. A few works have been published dealing with both the removal of the non-polymeric layers and the m…

Laboratorio camerte 2016

2017

Le tematiche affrontate nella XXVI edizione del ‘Seminario Internazionale e Premio di Architettura e Cultura Urbana’ hanno rivolto l’attenzione al risanamento e al riuso di spazi, di luoghi e di quartieri urbani dismessi, abbandonati o degradati. Le riflessioni concettuali, teoriche, analitiche, ma soprattutto progettuali presentate nei Seminari e nei Laboratori hanno fornito ulteriori contributi nella proposizione di nuove realtà funzionali indirizzate alla riqualificazione di territori urbani ritenuti oggi ‘vuoti’ non vivibili. Quanto emerso trova riscontro nelle riflessioni introduttive al Seminario del Direttore del SACU, arch. Giovanni Marucci, che sottolinea come sia presente nel prog…

High-Performance Lead-Acid Batteries Enabled by Pb and PbO2 Nanostructured Electrodes: Effect of Operating Temperature

2021

Lead-acid batteries are now widely used for energy storage, as result of an established and reliable technology. In the last decade, several studies have been carried out to improve the performance of this type of batteries, with the main objective to replace the conventional plates with innovative electrodes with improved stability, increased capacity and a larger active surface. Such studies ultimately aim to improve the kinetics of electrochemical conversion reactions at the electrode-solution interface and to guarantee a good electrical continuity during the repeated charge/discharge cycles. To achieve these objectives, our contribution focuses on the employment of nanostructured electr…

Novel green bio-composite geopolymeric thermo-plasters for innovative building applications: upcycling spent coffee ground

2022

This study proposes the reuse of spent coffee ground and biomass fly ash in the development of green geopolymeric thermo-plastering for innovative building applications. The former waste is the major residue of the brewing process, that is usually used as fertilisers or disposed of in landfill with extreme harmfulness for the natural environment. The latter is an industrial waste generated during the Kraft paper-pulp process, that is usually landfilled. The mortar is produced with a combination of metakaolin (30 wt.%) and biomass fly ash (70 wt.%), and natural siliceous sand filled with spent coffee ground (up to 17.5 wt.%). The high amount of reused waste makes the material an optimum cand…

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…