Search results for "Cyclin"
showing 10 items of 1021 documents
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
Design for recyclability and the avoidance of waste: the case of printed paper in Germany
1999
This paper discusses the generation of process waste in printed paper recycling and some factors affecting the amount of de-inking waste. The effects on waste generation by paper grades, which are designed for improved recyclability, are pointed out. The amount of waste generated is considered as the improvement in recyclability. This corresponds to a reduction in the use of materials that cannot be recycled, which, in the case of paper means lowering their mineral content. Two scenarios of a dynamic model of the fluxes of printed paper in Germany between 1993 and 2000 are used to analyse the amount of waste generated. No product changes are assumed in the first scenario, whereas improved …
Replication Data for: Cartobike transcripts focus group interviews
2020
This dataset contains replication data for our journal article "Cumbersome but desirable – breaking the code of everyday cycling". The dataset includes the transcripts (one file for each transcript) from the nine focus group interviews conducted as the qualitative part of the project From cars to bikes (Cartobike). The interviews were conducted after each of the three cycling periods, covering the autumn, winter and spring season, respectively, for each of the three included bike types, i.e. ebike with trailer, longtail bike and traditional bike with trailer. The main aim of the interviews was to explore participants' (parents of young children attending kindergarten) experiences with using…
Cumbersome but desirable—Breaking the code of everyday cycling
2020
IntroductionCycling for transport could integrate physical activity (PA) into daily routines and potentially increase total PA levels. However, for parents with young children, most factors affecting transport mode choice tend to facilitate car use. Greater insight is necessary into reasons for (not) using sustainable transport modes in parents with young children. Therefore, the objective of this study was to explore the experiences, including motives, perceptions, attitudes, and norms, of parents of young children by using an e-bike, a longtail bike, and a traditional bike for everyday travel to the workplace, kindergarten, and the grocery store during the autumn, winter, and spring, in n…
Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma
2010
Notch can act as an oncogene or as a tumour suppressor and thus can either promote or inhibit tumour cell growth. To establish Notch status in Ewing's sarcoma family of tumours (ESFT), we investigated the Notch pathway by gene expression profiling meta-analysis or immunohistochemistry in samples obtained from 96 and 24 ESFT patients, respectively. We found that although Notch receptors were highly expressed, Notch did not appear to be active, as evidenced by the absence of Notch receptors in cell nuclei. In contrast, we show that Notch receptors known to be active in colon adenocarcinoma, hepatocarcinoma, and pancreatic carcinoma stain cell nuclei in these tumours. High expression of the No…
Progress in neuropathology of the neuronal ceroid lipofuscinoses.
1999
Abstract Since the last, 6th, International Congress on Neuronal Ceroid-Lipofuscinoses, neuropathological advances in neuronal ceroid lipofuscinoses (NCL) have been made in several areas: (1) In adult NCL (ANCL) lipopigments have now been repeatedly confirmed to contain subunit c of mitochondrial ATP synthase and even sphingolipid activators (saposins). ANCL lipopigments have also been confirmed in extracerebral tissues including skin, skeletal muscle, and spleen, but not yet lymphocytes (2). Among circulating blood cells not only B cells and subclasses of T lymphocytes, i.e., CD4 + , CD8 + , and CD56 cells, but also monocytes have been found to contain NCL lipopigments, indicating that thi…
An in vitro study showing the three-dimensional microenvironment influence over the behavior of head and neck squamous cell carcinoma
2011
Objectives: The Head and Neck Squamous Cell Carcinoma (HNSCC) ranks sixth worldwide. The mechanisms of growth, invasion and metastasis of this pathology are extensively studied and generally related to specific variations in signaling pathways like the PI3K-Akt; however most of these competent studies have been performed bidimensionally, which may hide important questions. This study sought to analyze the influence of the microenvironment upon the behavior of HNSCC. Study Design: The status of pAkt, NF-κB and Cyclin D1 proteins was accessed through immunofluorescence and western blot methods in HNSCC cell lines originating from tongue, pharynx and metastatic lymph node when submitted to a t…
Kit Is Expressed by Epithelial Cells In Vivo
2003
In mammalian skin, stem cell factor (SCF) regulates the proliferation and maturation of mast cells and melanocytes, which are thought to be the only cutaneous cells that express the Kit-tyrosine kinase receptor (Kit) and respond to epithelial and mesenchymal-derived SCF. We previously had noted, however, the presence of Kit+ cells in murine hair follicles, in an introepithelial tissue compartment devoid of melanocytes and mast cells. Here we have identified the nature of this Kit+ population of cells in hair follicles of C57BL/6 mice. Anagen hair follicles showed strong Kit immunoreactivity not only in the pigmentary unit above the follicular dermal papilla but also in a much more proximall…
The effects of mental fatigue on sport-related performance
2018
International audience; Mental fatigue is known to increase subjective feelings of fatigue and to decrease cognitive performance, but its impact on physical performance remains poorly understood. The aim of this chapter was to review the results of 29 studies published between 2009 and April 2018 and focusing on the impact of mental fatigue on sport-related performance. Taken all studies together, it appears that mental fatigue impairs endurance performance, motor skills performance and decision-making performance. However, maximal force production is not reduced in the presence of mental fatigue. These observations suggest that mental fatigue impairs sport-related performance during exerci…
Recycling plus: A new recipe for the formation of Alpine-Himalayan orogenic mantle lithosphere
2013
Abstract The origin of the lithospheric mantle beneath accretionary orogens is enigmatic; although severe compression of the buoyant crust occurs, the mantle lithosphere is generally thought to be removed and returned to the convecting mantle. We suggest that during the accretion of oceanic arcs and small continental blocks in the Mediterranean region, and more generally throughout the whole Alpine–Himalayan orogenic belt, the mantle lithosphere is newly created and composed of intimately mixed peridotite and crustal material from the forearc region. Potassium-rich volcanic rocks emplaced sometimes more than 30 Ma after the formation of this lithosphere carry evidence for the presence of ex…