Search results for "Cyclin"
showing 10 items of 1021 documents
An Ethnographic Exploration of Southern Norwegian Second-Hand Cultures
2019
Master's thesis Global development and planning UT506 - University of Agder 2019 n this era of online shops and big retail shops, second-hand markets still exist in many places, including in Norway. Second-hand markets in this thesis consist of flea markets and second-hand shops. Flea markets open in spring, summer, and autumn in Southern Norway. These markets are established by various communities, clubs, and organizations. Some flea markets are also opened by individuals. On the other hand, thrift shops or bruktbutikker open through year. Second-hand shops are also established by non-profit organizations or individuals. This study explores the culture of second-hand marketsin Southern Nor…
Prostacyclin inhibits adhesion of polymorphonuclear leukocytes to human vascular endothelial cells due to adhesion molecule independent regulatory me…
2002
Prostacyclin is an important endothelial mediator involved in the interaction of neutrophils (PMN) with the vessel wall. Many studies have shown the beneficial effects of prostacyclin in ischemia and reperfusion. However, no previous study has investigated the direct effects of the prostacyclin analogs iloprost (ILO) and alprostadil (PGE(1)) on the endothelial part of the adhesion process. Human umbilical vein endothelial cells (HUVECs) were grown to confluence, stimulated with 300 U/ml TNF-alpha and treated with increasing concentrations of ILO and PGE(1). The cells were washed to remove TNF and the inhibitors and adhesion of fluorescence-green labeled PMN was determined microscopically. I…
Indomethacin enhances endothelial NO release — evidence for a role of PGI2 in the autocrine control of calcium-dependent autacoid production
1998
Objective: We studied whether NO or prostacyclin (PGI2), which are continuously released by endothelial cells, have autocrine/paracrine effects on the calcium-dependent autacoid production by modulating the intracellular Ca2+ concentration ([Ca2+]i). Methods: Histamine(His)-induced [Ca2+]i increases (Fura 2-method) and NO-dependent cGMP increase were measured in human umbilical vein endothelial cells (HUVECs) before and after cyclooxygenase inhibition or application of cAMP- and cGMP-elevating drugs. Results: 0.3 μM His increased endothelial [Ca2+]i from 77±2 nM to 418±59 nM. The His-induced [Ca2+]i increases were significantly attenuated following treatment with PGI2 (by 23%) and forskolin…
Phytoestrogens increase the capacity of serum to stimulate prostacyclin release in human endothelial cells
2003
Both the estrogen receptor (ER) alpha and beta isoforms are expressed in the endothelium. The ER beta has been assigned a crucial role in normal vascular wall function. Prostacyclin has been ascribed a beneficial effect on vessel wall physiology. Isoflavones bind with higher affinity to ER beta. We investigated the hypothesis that their administration to postmenopausal women can promote endothelial prostacyclin production.Twenty-five healthy postmenopausal women with mild climacteric symptoms received capsules containing 55 mg/day isoflavones derived from soy and red clover for 6 months. Cultured human umbilical vein endothelial cells (HUVECs) were exposed for 24 h to serum collected before…
Risvegli
2015
Il contributo descrive il lavoro condotto per il workshop PMO/Re-verse Hyper-cycling “Costa Sud”. La suggestione dalla quale si è partiti nell’affrontare le attività del workshop è stata quella di riconoscere nella Costa Sud di Palermo i “materiali” e, piuttosto che individuare i cicli interrotti, quelli “dormienti”, cioè quegli elementi dotati di energia potenziale che possa con facilità essere rimessa in circolo per “risvegliare” il metabolismo urbano dell’area. La volontà è stata quella di ricostruire, a partire dalle potenzialità esistenti, una visione che dall’individuazione dei singoli materiali avvia azioni di hyper-cycle per la costruzione di una nuova immagine del tratto di mare, e…
Manipolazione tipologica
2021
The team, since the early stages of the project, has worked with the will to seize, in collaboration and multidisciplinary dialogue, an opportunity for cultural and scientific growth to achieve shared solutions. The regeneration of the area subject of this study has assumed four elementary actions as operational tools declined to the urban, architectural and technological scale: include, subtract, add and connect. In Tor Bella Monaca, the lack of sense of urbanity is the real cause of environmental discomfort. The size, the layout and the position of the large residential units deprive the inhabitants of a sense of belonging to the city that has been reformulated by reorganizing the greener…
Motivating Physical Activity for Individuals with Intellectual Disability through Indoor Bike Cycling and Exergaming.
2022
People with intellectual disabilities have more sedentary lifestyles than the general population. Regular physical activity is of both medical and social importance, reducing the risk of cardiovascular disease and promoting functioning in everyday life. Exergames have been envisioned for promoting physical activity; however, most of them are not user-friendly for individuals with intellectual disabilities. In this paper, we report the design, development, and user acceptance of a mobile health solution connected to sensors to motivate physical activity. The system is mounted on an indoor stationary bicycle and an ergometer bike tailored for people with intellectual disabilities. The develop…
Influence of a new bicycle crank design on aerobic parameters of non-cyclists
2012
The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model.
2015
International audience; To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylamino-2'-7'-difluorofluorescein diacetate) and DAR-4M-AM (diaminorhodamine-4M). This method revealed that nitric oxide production could be co-localized with the tumor xenograft in 46% of the embryos. In 85% of these embryos, tumors were vascularized and blood vessels were observed on day 4 post injection. Furthermore, we demonstrated by qRT-PCR that the transplanted glioma ce…
Occurrence of Drug-Resistant Bacteria in Two European Eel Farms
2005
ABSTRACT The occurrence of strains that are resistant to oxolinic acid, oxytetracycline, sulfamethoxazole-trimethoprim, and nitrofurantoin among heterotrophic bacteria, including human and fish pathogens, in two freshwater eel farms was investigated. High levels of individual- and multiple-drug-resistant bacteria were detected, although sampling events were not correlated with clinical outbreaks and drug therapy.