Search results for "Cyclin"
showing 10 items of 1021 documents
Daidzein has neuroprotective effects through ligand-binding-independent PPARγ activation.
2011
Phytoestrogens are a group of plant-derived compounds that include mainly isoflavones like daidzein. Phytoestrogens prevent neuronal damage and improve outcome in experimental stroke; however, the mechanisms of this neuroprotective action have not been fully elucidated. In this context, it has been postulated that phytoestrogens might activate the peroxisome proliferator-activated receptor-γ (PPARγ), which exerts neuroprotective effects in several settings. The aim of this study was to determine whether the phytoestrogen daidzein elicits beneficial actions in neuronal cells by mechanisms involving activation of PPARγ. Our results show that daidzein (0.05-5 μM) decreases cell death induced b…
Age and gender differences in half-Ironman triathlon performances - the Ironman 70.3 Switzerland from 2007 to 2010
2012
Beat Knechtle,1,2 Christoph Alexander Rüst,2 Thomas Rosemann,2 Romuald Lepers31Gesundheitszentrum St Gallen, St Gallen, Switzerland; 2Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland; 3INSERM U1093, Faculty of Sport Sciences, University of Burgundy, Dijon, FranceBackground: To date, the age-related decline and gender differences in performance have been investigated for both Olympic and Ironman distance triathlons, but not for the intermediate distance (ie, the half-Ironman distance triathlon covering 1.9 km swimming, 90 km cycling and 21.1 km running, Ironman 70.3®). We determined the age-related differences in performan…
Validity of a novel device for indoor analysis of cyclists' drag area
2021
Cyclists need to measure aerodynamic resistance accurately and reliably, as well as economically. Devices such as Notio Aerostick, an equipment device that includes one pitot tube, have appeared for this purpose. The aim of this study is, therefore, to test the reliability and degree of agreement in the evaluation of the CdA (coefficient of aerodynamic drag), assessed by means of the Notio Aerostick compared to the Virtual Elevation (VE) and Martin mathematical models.Seventeen professional cyclists rode in a 250-metre-long velodrome covered with a concrete surface with their own time trial bikes. Each cyclist completed three rides of 15 laps at constant speed for the evaluation of the CdA,…
Participation and performance trends in ultra-triathlons from 1985 to 2009.
2011
International audience; We examined the changes in participation and performance trends in ultra-triathlons, from the Double Iron (7.6 km swimming, 360 km cycling, 84.4 km running) to the Deca Iron (38 km swimming, 1800 km cycling, 422 km running), between 1985 (first year of a Double Iron) and 2009 (25 years). The mean finish rate for all distances and races was 75.8%. Women accounted for ∼8-10% of the ultra-triathlons starters. For Double and Triple Iron, the number of finishers per year increased, from 17 to 98 and from 7 to 41, respectively. In the Deca Iron, the finishers per race have remained <20 since the first event was held, up to 2009. Concerning World best performances, the men …
Development of energy-saving innovative hydraulic mortars reusing spent coffee ground for applications in construction
2023
This paper reports the development of green bio-composite mortars, obtained reusing spent coffee ground (SCG), an agri-food residue, in the light of the Circular Economy approach. This process can boost the sustainability in Construction and proposes an alternative to SCG disposal in landfill, potentially dangerous to humans and the environment. For the first time, specimens were produced and compared using different blends of conventional hydraulic binders (ordinary Portland cement and natural hydraulic lime); SCG partially substituted sand (up to 15 wt.%, with a 2.5% increment) for the aggregate mix. The manufacturing process was performed at ambient conditions (20°C, 65% RH) resulting hi…
Physical exercise induces rapid release of small extracellular vesicles into the circulation
2015
Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the circulation. Healthy individuals were subjected to an incremental exercise protocol of cycling or running until exhaustion, and EVs were isolated from blood plasma samples taken before, immediately after and 90 min after exercise. Small EVs with the size of 100–130 nm, that carried proteins character…
The heterogeneity of the Mexican lithospheric mantle: Clues from noble gas and CO2 isotopes in fluid inclusions
2022
The abundance of mantle-derived rocks and lavas, in combination with its tectonic evolution, render Mexico a perfect laboratory to investigate the chemical and the isotopic heterogeneity of the lithospheric mantle. New data on the composition of noble gases and CO2in Mexican mantle xenoliths and lavas is reported. Our samples consist of six ultramafic nodules from the Durango Volcanic Field (DVF) and the San Quintin Volcanic Field (SQVF), monogenetic complexes belonging to the Mexican Basin and Range province; and four lavas from the Sierra Chichinautzin (SCN), a Quaternary monogenetic volcanic field located in the Mexican volcanic arc. Ne and Ar isotopes in fluid inclusions reveal mixing b…
Eastern Ancient Terrane of the North China Craton
2016
Based on the spatial distribution of ancient rocks and zircons, three ancient terranee older than ca. 2.6 Ga have recently been identified in the North China Craton, namely the Eastern, Southern, and Central Ancient Terranee. The Eastern Ancient Terrane is the best studied and understood of the three ancient terranes. It has a long geological history back to ca. 3.8 Ga ago and includes the areas of Anshan-Benxi, eastern Hebei, eastern Shandong and western Shandong. In Anshan-Benxi, several different types of 3.8 Ga rocks were discovered together with 3.1–3.7 Ga rocks, whereas 2.9–3.0 Ga K-rich granites and 2.5 Ga syenogranite occur on larger scales. In eastern Hebei, 3.0–3.4 Ga rocks and ol…
Generation of early Archaean grey gneisses through melting of older crust in the eastern Kaapvaal craton, southern Africa
2014
Abstract We report zircon ages, Hf-in-zircon isotopes as well as whole-rock geochemistry and Hf–Nd isotopic systematics for Palaeoarchaean grey gneisses of the Ancient Gneiss Complex of Swaziland, the oldest components of the Kaapvaal craton, southern Africa. The Hf-in-zircon isotopic compositions in these compositionally heterogeneous, multicomponent, migmatitic gneisses are highly variable, even in the oldest zircons dating back to 3.66 Ga, suggesting growth of zircon from melts representing a mix of juvenile and anatectic material derived from differentiated continental crust of Eoarchean to late Hadean age. In contrast, the initial Nd and Hf whole-rock isotopic compositions are frequent…
Palaeozoic arc magmatism in the Central Asian Orogenic Belt of Kazakhstan: SHRIMP zircon ages and whole-rock Nd isotopic systematics
2008
Abstract Early Palaeozoic tonalite to granodiorite intrusions in northern Kazakhstan are associated with lode gold mineralization and have SHRIMP zircon ages of 457.3 ± 6.6 Ma (Aksu), 452.9 ± 5.6 Ma and 447.4 ± 5.4 Ma (both Zholymbet). The Stepnyak intrusion contains large xenoliths with an age of 480.6 ± 5.0 Ma. One early Palaeozoic zircon from a porphyritic diorite at Stepnyak has a core with a near-concordant 207Pb/206Pb age of 3888 ± 1.5 Ma, whereas other xenocrystic grains are between 983 and 2698 Ma old. The early Archaean age is probably inherited from unexposed basement of the Kokchetav Massif and represents the oldest crustal material so far known from the Asian continent. It appea…