Search results for "D-"
showing 10 items of 12236 documents
Randomized Trial : D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans
2021
Background: Based on earlier studies, natural metabolite D-glyceric acid (DGA) does not seem to play any role in whole-body metabolism. Nevertheless, one ethanol oxidation-related rat study with controversial results raised our interest. According to preparatory studies for the regulatory approval of DGA, some highly conserved mechanism seems to subtly activate the cellular energy metabolism. Therefore, the present 25-days double-blind human study with placebo control was initiated. Purpose: The main target in the present study with 27 healthy 50–60-year-old human volunteers was to find out whether an “acute” 4-days and a longer 21-days exogenous DGA regimen caused moderate activation of th…
Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid
2022
It has been shown that small doses of oral D-glyceric acid (DGA) activate mitochondrial metabolism and reduce inflammation among 50–60-year-old healthy volunteers. The present results with the same small doses reveal that after a 4-day DGA regimen, a dose of DGA activated the HO-1 pathway acutely, while enhanced inflammatory status after the 4-day DGA regimen seemed to be able to downregulate the HO-1 pathway in non-acute measurement. Blood bilirubin was strongly upregulated towards the end of the altogether 21-day study period with positive associations towards improved inflammation and reduced blood triglycerides. After the 4-day DGA regimen, hepatic inflow of blood bilirubin with albumin…
Kriisinkestävä koulu
2022
Meitä edelleen kiusaavan pandemian alettua suomalainen yhteiskunta pysähtyi tai joutui muuttamaan käytäntöjään monella toiminta-alueella. Yksi koko yhteiskuntaa heijasteleva toiminta-alue oli koululaitos eri tasoillaan. Marja-Kristiina Lerkkanen tarkastelee artikkelissaan tuoreisiin tutkimustuloksiin perustuen opettajien työn ja työtilanteen muuttumista ja sen heijastumista niin oppilaisiin kuin koko koulun toimintaan. Esiin nousevat koulujen ja kotien resurssit selvitä muuttuneessa tilanteessa sekä täysin uudesta tilanteesta saatavat opit tulevaisuutta ajatellen. nonPeerReviewed
Income and Career Concerns Among Emerging Adults From Finland, Sweden, and the United Kingdom During COVID-19
2023
In this study, we examine the prevalence of income and career concerns among emerging adults in three different welfare states during COVID-19: Finland ( n = 309), Sweden ( n = 324), and the United Kingdom ( n = 343). This study also delves into how factors such as one’s self-perceived financial situation, generalized mistrust, loneliness and socio-demographics are related to emerging adults’ income and career concerns. Results showed that individuals from the United Kingdom were more likely to experience increased income and career concerns than those in Finland and Sweden. Our results also suggest that income concerns were associated with one’s current financial situation, future financi…
Is personality related to permanent earnings? Evidence using a twin design
2018
Using twin survey combined with register-based panel data on labor market outcomes, the authors examine the association between personality characteristics and long-term earnings among prime working-age individuals. The long-term earnings were measured over the 1990–2008 period. The sample contains 4,642 twin pairs, of which 53% are females. In contrast to previous studies, this paper uses the within-twin dimension of the data to control for shared family background and confounding genetic factors. The results suggest that unobserved genetic differences may introduce omitted variable bias in standard ordinary least square results. After controlling for shared environment and genetic backgro…
Techno-economic pre-feasibility study of wind and solar electricity generating systems for households in Central Finland
2014
The objective of this work is to investigate the viability of a wind, PV or hybrid wind-PV system supplemented with battery storage for electricity production to meet the electricity consumption of a typical household apartment in Central Finland. The assessment criteria for the analysis were cost of energy and total net present cost of each system configuration. We selected the Hybrid Optimization Model for Electric Renewables (HOMER) software, RETScreen, and PVsyst in our analysis and finally only HOMER was considered for performing system optimization analysis because of the creditability of its results. A PV-battery system is recognized as the most economically feasible option in our si…
Palladium-NHC (NHC = N-heterocyclic Carbene)-Catalyzed Suzuki–Miyaura Cross-Coupling of Alkyl Amides
2022
We report the Pd-catalyzed Suzuki–Miyaura cross-coupling of aliphatic amides. Although tremendous advances have been made in the cross-coupling of aromatic amides, C–C bond formation from aliphatic amides by selective N–C(O) cleavage has remained a major challenge. This longstanding problem in Pd catalysis has been addressed herein by a combination of (1) the discovery of N,N-pym/Boc amides as a class of readily accessible amide-based reagents for cross-coupling and (2) steric tuning of well-defined Pd(II)-NHC catalysts for cross-coupling. The methodology is effective for the cross-coupling of an array of 3°, 2°, and 1° aliphatic amide derivatives. The catalyst system is user-friendly, sinc…
Strictly correlated electrons approach to excitation energies of dissociating molecules
2019
In this work we consider a numerically solvable model of a two-electron diatomic molecule to study a recently proposed approximation based on the density functional theory of so-called strictly correlated electrons (SCE). We map out the full two-particle wave function for a wide range of bond distances and interaction strengths and obtain analytic results for the two-particle states and eigenenergies in various limits of strong and weak interactions, and in the limit of large bond distance. We then study the so-called Hartree-exchange-correlation (Hxc) kernel of time-dependent density functional theory which is a key ingredient in calculating excitation energies. We study an approximation b…
Digitalisaation vaikutukset työhyvinvointiin ja työtyytyväisyyteen
2021
Digitalisaatiota, työhyvinvointia ja työtyytyväisyyttä on tutkittu paljon. COVID -19 muutti työntekoa ja suurin osa työntekijöistä joutui siirtymään lyhyessä ajassa etätyöhön. Etätyöskentely on puolestaan nostanut esiin uusia työhyvin vointiin ja työtyytyväisyyteen liittyviä seikkoja. Olemme siirtyneet uudelle aika kaudelle työnteossa ja etätyöstä on tullut uusi normaali. Tämän tutkimuksen ai heena oli työn digitalisaatio ja etätyöskentely. Tutkimuskysymyksenä oli, miten työn digitalisaatio on vaikuttanut työhyvinvointiin ja työtyytyväisyyteen? Tutki muskysymykseen vastattiin käyttämällä tutkimusmetodina kirjallisuuskatsausta, jossa käytiin läpi lukuisia aineistoja, joissa oli käsitelty työ…
COVID-19 Remote Work : Body Stress, Self-Efficacy, Teamwork, and Perceived Productivity of Knowledge Workers
2021
Due to COVID-19, companies were forced to adopt new work processes, and reduce modern work environments such as collaboration spaces. Professionals from many fields were forced to work remotely, almost overnight. Little is known about the impact of such non-volunteer remote work on productivity, stress, and other key aspects of work performance. To further our understanding of the impacts of this situation and remote work in general, we conducted an exploratory study by studying 28 knowledge work professionals (researchers, software developers, interior designers, service designers, and development consultants) from the viewpoint of perceived productivity and aspects affecting it in this un…