Search results for "D1"
showing 10 items of 3056 documents
Immunomodulatory and Hematopoietic Effects of Recombinant Human Interleukin-6 in Patients with Advanced Renal Cell Cancer
1996
Interleukin-6 (IL-6) is a cytokine with pleiotropic biologic activities on B cells, T cells, and hematopoietic progenitors. The present study was undertaken to assess pharmacodynamic effects of subcutaneous administration of IL-6 on blood counts, immunologic parameters, and acute-phase reactants. Blood samples were taken from patients with advanced renal cell cancer participating in a phase II trial of recombinant human IL-6. Multiparameter FACS analyses of peripheral blood mononuclear cells were performed using antibodies against CD3, CD4, CD8, HLA-DR, CD56, CD28, CD38, CD19, sIgM, and sIgG. Serum levels of IL-10, soluble CD23 (sCD23), sCD25, IL-1 receptor antagonist protein (IL-1RA), solu…
Concentrations, composition, and sources of ice-nucleating particles in the Canadian High Arctic during spring 2016
2019
Modelling studies suggest that the climate and the hydrological cycle are sensitive to the concentrations of ice-nucleating particles (INPs). However, the concentrations, composition, and sources of INPs in the atmosphere remain uncertain. Here, we report daily concentrations of INPs in the immersion freezing mode and tracers of mineral dust (Al, Fe, Ti, and Mn), sea spray aerosol (Na+ and Cl−), and anthropogenic aerosol (Zn, Pb, NO3-, NH4+, and non-sea-salt SO42-) at Alert, Canada, during a 3-week campaign in March 2016. In total, 16 daily measurements of INPs are reported. The average INP concentrations measured in the immersion freezing mode were 0.005±0.002, 0.020±0.004, and 0.186±0.040…
Association between Serum Heat Shock Proteins and Gamma-Delta T Cells—An Outdated Clue or a New Direction in Searching for an Anticancer Strategy? A …
2021
HSPs demonstrate a strong association with gamma-delta (γδ) T cells. Most of the studies regarding interactions between the parameters were conducted in the 1990s. Despite promising results, the concept of targeting γδ T cells by HSPs seems to be a forgotten direction due to potent non-peptidic phosphoantigens rather than HSPs have been found to be the essential stimulatory components for human γδ cells. Currently, with greater knowledge of lymphocyte diversity, and more accurate diagnostic methods, we decided to study the correlation once again in the neoplastic condition. Twenty-one children with newly diagnosed acute lymphoblastic leukaemia (ALL) were enrolled on the study. Serum HSP90 c…
Melatonin and phytomelatonin: Chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animals—an overview
2021
Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of several physiological processes in both animals and plants. In the last century, it was reported that this molecule may be produced in high concentrations by several species belonging to the plant kingdom and stored in specialized tissues. In this review, the main information related to the chemistry of melatonin and its metabolism has been summarized. Furthermore, the biosynthetic pathway characteristics of animal and plant cells have been compared, and the main differences between the two systems highlighted. Additionally, in order to investigate the distribution of this indolamine in the plan…
QUALITY OF GROUNDWATER AND AQUATIC HUMIC SUBSTANCES FROM MAIN RESERVOIRE OF GROUND WATER No. 333
2015
The conducted research included the estimation of the quality of groundwater from the Main Reservoir of Ground Water No. 333 area in Opole District, Poland. The groundwater in the analyzed region shows high diversity in quality. The main threat for the quality of water in this region is the human household activity. The main pollutants of groundwater are: dissolved phosphorus, nitrate and ammonium. The quality and quantity of dissolved humic substances in groundwater were also investigated. The results showed that the contents of water-extractable organic carbon varied. Presently, the analyzed groundwater is characterized by large differences in dissolved forms of organic carbon. During mig…
Les ultimes feux de la résistance païenne dans l'antiquité tardive
2010
Os trabalhos recentes do autor convidam a um exame renovado do significado ideológico e religioso de certas fontes historiográficas importantes do final do século IV, entre as quais a História Augusta. De fato, parece que esta obra se inscreve, com outras, no contexto do último combate conduzido contra o cristianismo triunfante pelos derradeiros defensores da antiga religião da qual Nicômaco Flaviano sênior surge como o principal líder. De 384, data da morte de Pretextato, a 395. data da morte de Teodósio, os pagão puderam preservar os cultos antigos, chegando inclusive a armar-se em boa medida por este motivo, na batalha de Frígido. Entre 395 e 408, isto é, até o desaparecimento de Estili…
Brookite, the Least Known TiO2 Photocatalyst
2013
Brookite is the least studied TiO2 photocatalyst due to the difficulties usually encountered in order to obtain it as a pure phase. In this review, a comprehensive survey of the different methods available for preparing brookite powders and films is reported. Attention has been paid both to the most traditional methods, such as hydrothermal processes at high temperatures and pressures, and to environmentally benign syntheses using water soluble compounds and water as the solvent. Papers reporting the photocatalytic activity of pure and brookite-based samples have been reviewed.
BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.
2014
BRAF-V600E expression is identified in hematopoietic progenitor and precursor myeloid dendritic cells in patients with high-risk LCH, and enforced expression of BRAF-V600E in CD11c+ cells recapitulates a high-risk LCH-like phenotype in mice.
AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS
2000
H-IL-6 is a hybrid protein constructed to contain IL-6 and its soluble receptor linked by a flexible peptide chain. Here we show that H-IL-6 strongly enhances proliferation of human CD34(+)cells in serum-free liquid culture, and that the majority of the cells generated belong to the erythroid lineage, being positive for the marker Glycophorin A. Conversely, H-IL-6 does not increase the number of myeloid, CD13-positive cells. Comparable effects are observed on progenitors from cord blood and adult peripheral blood. Therefore, H-IL-6 triggers an erythroid-inducing signal in haematopoietic progenitor cells, independently from erythropoietin (EPO).
La rete mediterranea della devozione. Le teresiane della provincia di Napoli
2015
Riassunto: Filo conduttore del saggio è la vita di madre Serafina di Dio, carismatica caprese fondatrice, nel secolo XVII, di sette congregazioni femminili ispirate alla spiritualità teresiana. L’affiliazione alla santa di Avila e l’adesione alla matrice della sua riforma hanno consentito alle nuove comunità devote nate da un’iniziativa periferica di collocarsi nell’alveo della Chiesa nella prospettiva istituzionale della trasformazione in monasteri di clausura.Due i focus della ricerca. Da un lato ci si è soffermati sull’omogeneità organizzativa e spirituale dei conservatori garantita da reti devozionali saldamente dipendenti dal carisma della fondatrice secondo un meccanismo nel quale res…