Search results for "D11"
showing 10 items of 337 documents
Gastrointestinal stromal tumors (GISTs): Focus on histopathological diagnosis and biomolecular features
2007
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract that are believed to originate from a neoplastic transformation of the intestinal pacemaker cells (interstitial cells of Cajal) normally found in the bowel wall or their precursors. Although the microscopic features have been known for a long time, the defining characteristic of GIST is the presence of the cell-surface antigen CD117 (KIT), which is demonstrated by immunohistochemistry. KIT, which is a growth factor transmembrane receptor, is the product of the proto-oncogene c-kit (chromosome 4). Surgical removal remains the only curative treatment for patients with GISTs. Tumor size, mitotic index,…
Electroclinical features and outcome of ANKRD11-related KBG syndrome: A novel report and literature review.
2021
KBG syndrome (OMIM #148050) is a rare autosomal dominant disorder, typically characterized by macrodontia of the upper central incisors, distinct craniofacial findings, short stature, and skeletal anomalies associated with neurological involvement including intellectual disability, behaviour difficulties, and epilepsy. KBG syndrome is associated with mutations in ANKRD11 gene that plays a chromatin regulator role of histone acetylation and gene expression during neurogenesis in the embryonic brain.
Les cartes-marc de la Història de Valter e Griselda de Bernat Metge i les del Griseldis de Petrarca
2013
Resum: L’any 1388, Bernat Metge tradueix al catala el text llati en que Petrarca havia traslladat la darrera historia del Decamero de Boccaccio, la Historia de Valter e Griselda que el poeta d’Arezzo titula De insigni obedientia et fide uxoria . Embolcallant la seva versio de la historia, Petrarca remet sengles cartes al seu amic i autor del relat. En aquestes cartes li exposa els motius que l’han portat a traduir el text i fa consideracions sobre la conducta de Griselda. Metge tambe envolta la seva traduccio arromancada amb dues cartes i la dedica a madona Isabel de Guimera. Aquest treball es un estudi sobre l’enorme difusio que ha tingut el relat boccaccia en la historia de la literatura …
Organització i estructuració del poder al si d'un Orde Militar: el cas de l'Orde de Montesa (segles XIV-XV)
1995
The majority of works on the history of the Military Order of Montesa are based on classic works referring to the Modern Ages and therefore they assign to the Middle Ages meaningless scherna and organizational outlines. The purpose of this paper is to find out the territorial distribution of the Montesa manors in the Kingdom of Valencia at the time of its foundation, and its changes through the Middle Ages, emphasizing the distribution of powes and competences between the Friars memberships of the Order and the Master, owner of the rights of the “Mesa Maestral". We know that during the XIV and XV Centuries there was a concentration of power in the hands of the Master. With this authority, h…
Al servicio del rey. Sobre la carta real diplomática de la Corona de Aragón (1336-1458)
2017
El objetivo de este artículo es reconstruir la evolución morfológica de la carta real diplomática catalanoaragonesa entre los reinados de Pedro el Ceremonioso y Alfonso el Magnánimo. A lo largo de este período, esta tipología documental, siguiendo los principios del Ars dictaminis, adaptó sus características externas e internas a las acciones jurídicas que contenía y a sus destinatarios, sin renunciar por ello a su simplicidad material y textual. Con su adecuación a las necesidades comunicativas de la monarquía, la carta real diplomática se convirtió en un instrumento de gobierno que contribuyó al fortalecimiento del poder real y anticipó formas que alcanzarán su pleno desarrollo en época m…
Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming.
2014
Abstract In vivo studies questioned the ability of Langerhans cells (LCs) to mediate CD8+ T cell priming. To address this issue, we used intradermal immunization with plasmid DNA, a system in which activation of CD8+ T cells depends on delayed kinetics of Ag presentation. We found that dendritic cells (DCs) located in the skin at the time of immunization have limited ability to activate CD8+ T cells. This activity was mediated by a second generation of DCs that differentiated in the skin several days after immunization, as well as by lymph node–resident DCs. Intriguingly, CD8+ T cell responses were not affected following treatment with clodronate liposomes, immunization of CCR2−/− mice, or …
Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance
2012
Background Allergic contact dermatitis is one of the most common occupational diseases. A main protective mechanism in those who do not develop allergic contact dermatitis is tolerance induction by repeated exposure to low doses of contact allergen, which is termed low zone tolerance (LZT). The mechanisms that determine the tolerance induction in subjects with LZT are still elusive. Objective We performed analysis of the role of CD4 + CD25 + forkhead box protein 3 (FOXP3)–positive regulatory T (Treg) cells and dendritic cells (DCs) in mice with LZT. Methods Mechanisms of tolerance induction were analyzed in a murine model of LZT by using FOXP3 and IL-10 reporter mice, as well as mice that a…
Élites di governo e «mastre» ad Agrigento fra Trecento e Quattrocento
2002
ITALIANO: Sebbene le comunità demaniali siciliane acquisiscano un peso centrale ed inedito nei regni di Martino e di Alfonso V, a parte poche eccezioni mancano ricerche monografiche e comparate delle dinamiche sociali cittadine. Questo articolo prende in esame la città di Agrigento, in particolare la formazione dei raggruppamenti sociali, il loro differente ruolo politico e gli equilibri di potere tra i gruppi di governo, con riferimento alle istituzioni delle liste di eleggibili per l'elezione alle cariche locali. È opinione comune che le istituzioni di tali liste rappresentino l'affermazione della aristocrazia, sugli altri raggruppamenti sociali, nelle dinamiche urbane sin dalla seconda m…
El parlamento de Juan II ante las cortes generales de Monzón (1469). Una pequeña crónica autobiográfica en lengua castellanoaragonesa
2016
Resumen: Edicion critica y estudio historico, formal y linguistico del discurso con el que Juan II de Aragon abrio, el 13 de noviembre de 1469, las cortes generales de Monzon. En plena guerra civil catalana, los rebeldes habian ofrecido la corona a Renato de Anjou, y la llegada desde Francia de su hijo, el duque de Lorena, con un poderoso ejercito obligaba a pedir subsidios para afrontar la grave situacion. En este parlamento, una de las escasas muestras de aragones tardio conservadas, el monarca hizo un relato autobiografico de su reinado de innegable sesgo maniqueo. Palabras clave: Juan II de Aragon, oratoria parlamentaria, Corona de Aragon, cortes generales, siglo XV, guerra civil catala…
Jerarquización y especialización de los circuitos mercantiles valencianos (finales del XIV-primera mitad del XV)
1990
Hacia la tercera decada del siglo XV se configuro en la ciudad de Valencia un mercado de seguros maritimos, en el que la constante afluencia de capitales de los hombres de negocios y mercaderes, autoctonos o foraneos, confirmaba el afianzamiento de diversos canales de comercializacion que integraban la estructura economica del reino dentro de los circuitos europeos y que, por tanto, definian su funcion en la organizacion de las economias urbanas. La proliferacion de un tipo de transaccion, basada en la especializacion definida de un mercado, de un area geoeconomica, determinaba el exito de una ruta, al mismo tiempo que apoyaba su progresiva integracion en el mercado de seguros maritimos.