Search results for "D11"

Mast Cell–deficient KitW-sh “Sash” Mutant Mice Display Aberrant Myelopoiesis Leading to the Accumulation of Splenocytes That Act as Myeloid-Derived S…

2013

Abstract Mast cell-deficient KitW-sh “sash” mice are widely used to investigate mast cell functions. However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin. In this study, we demonstrate that KitW-sh causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/macrophage progenitors in the spleen. A consistent feature shared by these cell types is the reduced expression of c-Kit. Populations expressing intermediate and high levels of Ly6G, a component of the myeloid differentiation Ag Gr-1, are also highly expanded in the spleen of sash mice. These cells are …

Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo

2012

Increasing evidence suggests that antibodies can have stimulatory effects on T-cell immunity. However, the contribution of circulating antigen-specific antibodies on MHC class I cross-priming in vivo has not been conclusively established. Here, we defined the role of circulating antibodies in cross-presentation of antigen to CD8(+) T cells. Mice with hapten-specific circulating antibodies, but naϊve for the T-cell antigen, were infused with haptenated antigen and CD8(+) T-cell induction was measured. Mice with circulating hapten-specific antibodies showed significantly enhanced cross-presentation of the injected antigen compared with mice that lacked these antibodies. The enhanced cross-pre…

IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology.

2014

Gut homeostasis and mucosal immune defense rely on the differential contributions of dendritic cells (DC) and macrophages. Here we show that colonic CX3CR1+ mononuclear phagocytes are critical inducers of the innate response to Citrobacter rodentium infection. Specifically, the absence of IL-23 expression in macrophages or CD11b+ DC results in the impairment of IL-22 production and in acute lethality. Highlighting immunopathology as a death cause, infected animals are rescued by the neutralization of IL-12 or IFNγ. Moreover, mice are also protected when the CD103+ CD11b− DC compartment is rendered deficient for IL-12 production. We show that IL-12 production by colonic CD103+ CD11b− DC is r…

Monarchia e fondazioni clariane: due monasteri a Messina (secoli XIII-XIV)

2017

ITALIANO: Lo studio si propone di ricostruire i rapporti tra l’Ordine di Santa Chiara e la monarchia aragonese, testimoniati a Messina dal vivo interesse dei sovrani nei confronti dei monasteri clariani. In particolare, vengono messe a fuoco le vicende relative alla fondazione di due monasteri di clarisse: S. Chiara e S. Maria di Basicò. Parecchie le testimonianze che provano il legame dei due monasteri con regine e principesse: ad esempio Costanza, figlia di Manfredi di Svevia, dopo la morte del marito Pietro d’Aragona nel 1285, e del primogenito Alfonso nel 1291, si ritirò a vita religiosa vestendo l’abito delle clarisse; Eleonora d’Angiò, moglie di Federico III d’Aragona e figlia di Carl…

Le site du monastère Saint-Pierre d'Ilovik (îlot Saint-Pierre, Croatie) : première étude archéologique du bâti

2011

Ce monastère, très mal connu, est situé dans une petite crique de l’îlot Saint-Pierre faisant face à l’île d’Ilovik, immédiatement au sud de Lošinj. L’îlot Saint-Pierre était occupé durant l’Antiquité par une grande villa, dont des vestiges (murs et sols) sont encore visibles sur la grève de la façade occidentale (fig. 1). Fig. 1 – Saint-Pierre d’Ilovik, sondages dans les enduits du mur sud : découvertes des baies (cl. S. Bully). Les photographies aériennes révèlent également plusieurs orga...

Credit, Debt and FInances of the Queen's Household in the Crown of Aragon at the End of the Fourteenth Century. The Agreement between the Queen Viola…

2018

A finales del siglo XIV la tesorería de la reina Violante de Bar padecía de un fuerte endeudamiento que imposibilitaba prácticamente cualquier pago, por lo que se decidió cambiar la dirección de la gestión económica de la Casa de la reina. En el presente artículo analizaremos las estrategias para solucionar el problema del endeudamiento, mediante la edición y el análisis de los excepcionales capítulos y memoriales firmados por la reina Violante y su nuevo tesorero, Berenguer de Cortilles, uno de sus mayores acreedores privados. At the end of the Fourteenth century, Queen’s treasury in the Crown of Aragon suffered from a heavy debt that made virtually impossible any ordinary payment. As a re…

Per una nuova edizione della Cronica Sicilie di anonimo del Trecento

2006

Ricerca medievistica e rete telematica: l'esperienza di Reti Medievali

2005

Saggio critico di aggiornamento bibliografico

2007

Temptation and commitment in the laboratory

2010

Temptation and self-control in intertemporal choice environments are receiving increasing attention in the theoretical economics literature. Nevertheless, there remains a scarcity of empirical evidence from controlled environments informing behavior under repeated temptations. This is unfortunate in light of the fact that in many natural environments, the same temptation must be repeatedly resisted. This paper fills that gap by reporting data from a novel laboratory study of economic decisions under repeat temptations. Subjects are repeatedly offered an option with instantaneous benefit that also entails a substantial reduction to overall earnings. We show that this option is "tempting" in …