Search results for "D11"
showing 10 items of 337 documents
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells
2012
SummaryMature dendritic cells (DCs) are established as unrivaled antigen-presenting cells (APCs) in the initiation of immune responses, whereas steady-state DCs induce peripheral T cell tolerance. Using various genetic approaches, we depleted CD11c+ DCs in mice and induced autoimmune CNS inflammation. Unexpectedly, mice lacking DCs developed aggravated disease compared to control mice. Furthermore, when we engineered DCs to present a CNS-associated autoantigen in an induced manner, we found robust tolerance that prevented disease, which coincided with an upregulation of the PD-1 receptor on antigen-specific T cells. Additionally, we showed that PD-1 was necessary for DC-mediated induction o…
German Survey on EUS-Guided Diagnosis and Management of Gastrointestinal Stromal Tumors (GISTs) - Evidence or "Gut-Feeling"?
2015
To examine practice patterns of endosonographers in diagnosing and managing gastrointestinal stromal tumors (GISTs) in Germany.A modified published survey (Ha et al., Gastrointest Endosc 2009) was sent to endosonographic ultrasound (EUS) customers in Germany. The survey was also publicized on the homepage of an EUS interest group. To avoid duplicate opinions, participants were asked to return one survey per institution.142 centers of roughly 850 German EUS centers responded. 25 % were from University hospitals and 74 % from community hospitals. 61 % performed 2 EUS scans for suspected subepithelial lesions/week. Although 97 % of respondents believed that tissue acquisition with CD117 immuno…
El libro y la lectura en Valencia (1300-1410). Notas para su estudio
2020
Through this article, we try to underline some aspects related to the research undertaken on the book and its different uses. We have centred our attention on the social meanings of possessing a book for private individuals: the book as an instrument of work and/ or study, the book for entertainment, etc. Every single one attests to an attitude of the individual as regards the Written Culture and, above all, the role of the latter in the consolidation of a social status. Cet article tend à faire ressortir certains aspects en rapport avec la recherche sur le livre et ses différentes utilisations, en particulier les diverses significations de la possession d'un livre par les particuliers: le …
Extracorporeal Shock Waves Increase Markers of Cellular Proliferation in Bronchial Epithelium and in Primary Bronchial Fibroblasts of COPD Patients
2020
Chronic obstructive pulmonary disease (COPD) is due to structural changes and narrowing of small airways and parenchymal destruction (loss of the alveolar attachment as a result of pulmonary emphysema), which all lead to airflow limitation. Extracorporeal shock waves (ESW) increase cell proliferation and differentiation of connective tissue fibroblasts. To date no studies are available on ESW treatment of human bronchial fibroblasts and epithelial cells from COPD and control subjects. We obtained primary bronchial fibroblasts from bronchial biopsies of 3 patients with mild/moderate COPD and 3 control smokers with normal lung function. 16HBE cells were also studied. Cells were treated with a…
Historiografia del “Ball de Torrent”: De la moixiganga barroca al quadre de balls populars valencians (1692-1929)
2013
Resum: El Ball de Torrent és una moixiganga dramàtica popular escenificada a la ciutat de València i altres indrets del País Valencià des de finals del segle XVII fins a principis del segle XX. Estava organitzada per agrupacions gremials, juntes d’hospitals o clavaris de festes i protagonitzada per personatges agrupats en comparses que representaven una paròdia sobre les relacions entre les estructures de poder i les classes populars. Tot i la variabilitat segons el moment històric, es conforma com una mescla de quadres amb danses, música i jocs teatrals. El ball interacciona de diverses formes amb algunes festes valencianes i és, probablement, una de les mostres de teatre de carrer més nos…
Problematiche di valorizzazione, fruizione e musealizzazione dei beni culturali. Tecnologie innovative per la città ritrovata
2010
Approssimazione all’edizione italiana della «Cronica generale d’Hispagna et del regno di Valenza» di Pere Antoni Beuter (Venezia, Gabriele Giolito de…
2013
Riassunto: Il presente saggio si propone come una prima approssimazione allo studio dell’edizioneitaliana della Cronaca generale d’Hispagna et del regno di Valenza di Pere Antoni Beuter, pubblicatanel 1556 a Venezia da Gabriele Giolito de’ Ferrari nella traduzione dello spagnolo Alfonso deUlloa. Quest’opera storiografica si inserisce in un contesto culturale importantissimo come quellodella Venezia del Cinquecento, particolarmente effervescente nel campo dell’editoria con figure diprim’ordine come Giolito e Ulloa. Il saggio si divide in tre momenti: il primo è costituito da unabreve introduzione sull’opera di Beuter e sulla traduzione di Ulloa; il secondo presenta la schedacatalografica del…
Gene Signatures in Gastrointestinal Stromal Tumors
2011
Gastrointestinal stromal tumors (GISTs) constitute a rare heterogeneous group of the most common mesenchymal neoplasm of gastrointestinal tract (GI). GISTs have emerged during the recent years as a distinct sarcoma entity due to advances in the understanding of molecular mechanism of their pathogenesis. They are believed to originate from precursors shared with interstitial cells of Cajal (ICC) – the pacemaker cells of the gut (for which CD117 antigen is the immunohistochemical marker), and they may arise along all GI (most commonly in the stomach or the small bowel) or rarely elsewhere. Their biological behavior is difficult to predict, ranging from clinically benign to malignant. The trea…
A novel in vivo inducible dendritic cell ablation model in mice
2010
Abstract Dendritic cells (DCs) are involved in T cell activation via their uptake and presentation of antigens. In vivo function of DCs was analyzed using transgenic mouse models that express diphtheria toxin receptor (DTR) or the diphtheria toxin-A subunit (DTA) under the control of the CD11c/Itgax promoter. However, CD11c+ cells are heterogeneous populations that contain several DC subsets. Thus, the in vivo function of each subset of DCs remains to be elucidated. Here, we describe a new inducible DC ablation model, in which DTR expression is induced under the CD11c/Itgax promoter after Cre-mediated excision of a stop cassette (CD11c-iDTR). Crossing of CD11c-iDTR mice with CAG-Cre transge…
Martín I y la aparición del gótico internacional en el reino de Valencia
2003
This article focuses on the real presence of Martin I in the Kingdom of Valencia during a long period of time. This fact supposed the arrival and establishment of flemish, Italian painters and the own Crown of Aragón in the city of Turia. Orders not only by Martin I, first as a prince and later as the king, and close members of his court, but also by the own City Council allowed Valencia to be one of the most interesting cities for understanding the development of the International Gothic Style in the Crow of Aragon.<br><br>La presencia de Martín I en el reino de Valencia durante largos periodos de tiempo supuso un atractivo para el establecimiento de pintores flamencos, italian…