Search results for "D1"
showing 10 items of 3056 documents
Politisoitu rajaseutu : Lectio praecursoria 24.8.2012
2012
Antti Räihän Suomen historian väitöskirja Jatkuvuus ja muutosten hallinta. Hamina ja Lappeenranta Ruotsin ja Venäjän alaisuudessa 1720−1760-luvuilla tarkastettiin 24.8.2012 Jyväskylän yliopistossa. Vastaväittäjänä toimi tutkija Kari-Matti Piilahti Helsingin yliopistosta ja kustoksena professori Petri Karonen Jyväskylän yliopistosta.
Suomen metsät tarvitsevat toimivia monimuotoisuuskarttoja ja menetelmät päivityksiä – Vastine Kankaalle ja Mehtätalolle
2021
Espace et art de la formule visuelle à Rome sous le pontificat de Pascal Ier (817-824) : l’exemple de la basilique Sainte-Praxède
2006
Il s’agit de réfléchir sur les différentes formules (architecturales, textuelles et iconographiques) mises en œuvre par le pape Pascal Ier dans la basilique Sainte-Praxède à Rome et ce, afin de composer un discours ecclésiologique à la fois complexe et efficace. Figuré en porteur de maquette au sein même de l’église offerte, le pape se présente comme le fondateur d’un édifice dans lequel il cherche à se rendre omniprésent. Grâce à cette basilique conçue comme un reliquaire monumental, Pascal Ier se rapproche de plusieurs martyr(e)s romain(e)s et de Dieu tout en invitant les fidèles à dépasser le niveau du visible, du matériel, du sensible. La maquette de l’édifice présentée comme une matéri…
Naisten muistot työstä sodan ja jälleenrakennuksen ajalta kertovat jaksamisesta : lectio praecursoria 13.6.2014
2014
FM Kirsi-Maria Hytösen etnologian väitöskirja ”Ei elämääni lomia mahtunut” Naisten muistelukerrontaa palkkatyöstä talvi- ja jatkosotien ja jälleenrakennuksen aikana tarkastettiin 13.6.2014 Jyväskylän yliopistossa. Vastaväittäjänä toimi professori emerita Kaija Heikkinen Itä-Suomen yliopistosta ja kustoksena professori Pirjo Korkiakangas Jyväskylän yliopistosta.
Sustainability Development in Mathematics Education : A Case Study of What Kind of Meanings Do Prospective Class Teachers Find for the Mathematical S…
2019
In this article, our focus is on sustainable development in mathematics education from the point of view of teacher training. The aim was to develop prospective teachers’ content knowledge and pedagogical content knowledge of school mathematics. As a case study, we chose the mathematical symbol “a/b”, and examined how prospective class teachers in Finland connect it to the concepts of fraction, ratio, division, rational number or probability. Mathematics textbooks often have a central role in lessons, and they affect strongly how pupils understand concepts and the relationships between them. We chose languaging as a multi-semiotic approach to interpreting what kind of meanings the prospecti…
Application of Molecular Topology for the Prediction of Reaction Yields and Anti-Inflammatory Activity of Heterocyclic Amidine Derivatives
2011
Topological-mathematical models based on multiple linear regression analyses have been built to predict the reaction yields and the anti-inflammatory activity of a set of heterocylic amidine derivatives, synthesized under environmental friendly conditions, using microwave irradiation. Two models with three variables each were selected. The models were validated by cross-validation and randomization tests. The final outcome demonstrates a good agreement between the predicted and experimental results, confirming the robustness of the method. These models also enabled the screening of virtual libraries for new amidine derivatives predicted to show higher values of reaction yields and anti-infl…
Osteogenic differentiation of periodontal fibroblasts is dependent on the strength of mechanical strain
2012
Abstract Objective During orthodontic therapy the correct strength of mechanical strain plays a key role for bone remodelling during tooth movement. Aim of this study was to investigate the osteogenic differentiation of human periodontal ligament fibroblasts (HPdLF) depending on the applied strength of mechanical strain compared to osteoblasts (HOB). Design HPdLF and HOB were loaded with different strengths (1%, 5% and 10%) of static mechanical strain (SMS) for 12 h in vitro. Viability was verified by MTT and apoptosis by TUNEL assay. Gene expression of cyclin D1, collagen type-1 (COL-I), alkaline phosphatase (ALP), osteocalcin, osteoprotegerin (OPG) and receptor activator of the NF-κB liga…
Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis
2007
Abstract The transcription factor STAT4 mediates signals of various proinflammatory cytokines, such as IL-12, IL-15, and IL-23, that initiate and stabilize Th1 cytokine production. Although Th1 cytokine production has been suggested to play a major pathogenic role in rheumatoid arthritis, the role of STAT4 in this disease is poorly understood. In this study, we demonstrate a key functional role of STAT4 in murine collagen-induced arthritis (CIA). In initial studies we found that STAT4 expression is strongly induced in CD4+ T cells and to a lesser extent in CD11b+ APCs during CIA. To analyze the role of STAT4 for arthritis manifestation, we next investigated the outcome of interfering with S…
Influence of the Screw Positioning on the Stability of Locking Plate for Proximal Tibial Fractures: A Numerical Approach
2020
Tibial fractures are common injuries in people. The proper treatment of these fractures is important in order to recover complete mobility. The aim of this work was to investigate if screw positioning in plates for proximal tibial fractures can affect the stability of the system, and if it can consequently influence the patient healing time. In fact, a more stable construct could allow the reduction of the non-weight-bearing period and consequently speed up the healing process. For that purpose, virtual models of fractured bone/plate assemblies were created, and numerical simulations were performed to evaluate the reaction forces and the maximum value of the contact pressure at the screw/bo…
Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue
2016
Objectives Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development of Ankylosing Spondylitis and other spondyloarthropathies (SpA), yet the role it plays in disease pathogenesis remains unclear. We investigated the expression of potentially pathogenic non-conventional heavy chain forms (NC) of B27 in synovial and intestinal tissues obtained from SpA patients. We also determined the presence of NC-B27 in joints, lymphoid and gastrointestinal tissue from B27 transgenic (TG1) rats with M.tuberculosis-induced SpA. Methods Expression of NC-B27 in human SpA joints and gut and in (21-3 × 283-2)F1 HLA-B27/Huβ2m rat tissue was determined by immunohistochem…