Search results for "D1"
showing 10 items of 3056 documents
Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor.
2022
A series of novel menthone derivatives bearing pyrimidine and urea moieties was designed and synthesized to explore more potent natural product-derived antitumor agents. The structures of the target compounds were confirmed by FTIR, NMR, and HRMS. The in vitro antitumor activity was tested by standard methyl thiazolytetrazolium assay and showed that 4i, 4g, 4s, and 4m are the best compounds with IC50 values of 6.04 ± 0.62µM, 3.21 ± 0.67µM, 19.09 ± 0.49µM, and 18.68 ± 1.53µM, against Hela, MGC-803, MCF-7, and A549, respectively. The results of the preliminary action mechanism studies showed that compound 4i, the representative compound, could induce cell apoptosis in Hela cells in a dose-dep…
Performance Dissimilarities in European Union Manufacturing: The Effect of Ownership and Technological Intensity
2021
Our paper addresses the relevance of a set of continuous and categorical variables that describe industry characteristics to differences in performance between foreign versus locally owned companies in industries with dissimilar levels of technological intensity. Including data on manufacturing sector performance from 20 European Union member countries and covering the 2009–2016 period, we used the random forests methodology to identify the best predictors of EU manufacturing industries’ a priori classification based on two main attributes: ownership (foreign versus local) and technological intensity. We found that EU foreign-owned businesses dominate locally owned ones in terms of size, wh…
Proteins in Ionic Liquids: Reactions, Applications, and Futures
2019
Biopolymer processing and handling is greatly facilitated by the use of ionic liquids, given the increased solubility, and in some cases, structural stability imparted to these molecules. Focussing on proteins, we highlight here not just the key drivers behind protein-ionic liquid interactions that facilitate these functionalities, but address relevant current and potential applications of protein-ionic liquid interactions, including areas of future interest.
The proposal to transform an old limestone quarry into a botanical garden with a rainforest zone: a case study
2019
Nowadays, a significant part of cities is tackling the problems with post-mining areas. This manuscript is an original research which shows possibilities of their reclamation. The aim of the article is to present the proposal of developing the closed limestone quarry and creating a botanical garden. The proposed spatial solutions allow for creating a new, tourist and recreation space, maintaining the natural heritage. The work also assumed carrying out a dendrological inventory, in order to determine the existing dendrofl ora. The required spatial, nature and communication analyses, which illustrate the current condition of the area and defi ne further design works, have also been carried o…
Influence of brand image of a sports event on the recommendation of its participants
2020
The aim of this research is to test the psychometric properties and relationships of a model where, from brand congruence of a sport event, trust and commitment to it can be generated, influencing future behavior of participants and resulting in a higher recommendation also called Word of Mouth (hereinafter WOM). A quantitative approach has been carried out by means of a validated questionnaire with Likert-type responses, and data were analyzed with the EQS 6.4 software. The findings indicated that the model is adequate, and also confirm that from congruence, we can explain, at a theoretical level, 45% of trust, and in the same way, from the congruence and trust, we can explain 67% of the c…
The urban rent in the multicultural city: retail shops, migrants and urban decline in the historic centre of Palermo [La rendita urbana nella città m…
2020
Changes in consumer shopping behavior and in retail spaces, such as shopping malls, department stores and e-commerce, have modified localization models of traditional retail shops, also affecting urban fabric and spatial distribution of urban rent. Even city centers have undergone significant transformations or even decline, especially if local economic system and real estate market are weak and recessionary. A significant amount of commercial properties may have long vacancy due to excess supply, since many traditional shops close their business because they are no longer competitive and, moreover, there is no immediate takeover by new tenants. The decline of central urban areas depends on…
Determination of Changes in the Quality of Surface Water in the River—Reservoir System
2021
Assessing the changing parameters of water quality at different points in the river–reservoir system can help prevent river pollution and implement remedial policies. It is also crucial in modeling water resources. Multivariate statistical analysis is useful for the analysis of changes in surface water quality. It helps to identify indicators that may be responsible for the eutrophication process of a reservoir. Additionally, the analysis of the water quality profile and the water quality index (WQI) is useful in assessing water pollution. These tools can support and verify the results of a multivariate statistical analysis. In this study, changes in water quality parameters of the Turawa r…
Il ruolo del dirigente scolastico in tempi di pandemia da Covid-19: tra responsabilità legale e pedagogica
2021
In seguito all’attuazione della legge 59/1997 che con l’art. 21 conferisce l’autonomia didattica e organizzativa alle istituzioni scolastiche, la dirigenza della scuola è investita di una doppia carica che si snoda tra la responsabilità legale e la responsabilità pedagogica. Ciò si traduce per il Dirigente Scolastico in un incremento del suo potere d’azione in tutti gli ambiti della gestione della scuola (Di Liberto et al., 2019, p.121). La letteratura scientifica, peraltro, sottolinea che il successo delle imprese è strettamente correlato alla qualità della leadership, dell’organizzazione manageriale e alle pratiche educative (Bloom, Van Reenen, 2010). È possibile affermare che per attende…
The Effect of Mechanocatalytic Pretreatment on the Structure and Depolymerization of Willow
2020
In this study, the effect of a mechanocatalytic pretreatment on the structure of willow and sugar release from pretreated willow was explored. In the mechanocatalytic approach, the pretreatment consists of solvent-free impregnation with sulfuric acid and a mechanical treatment with ball milling. Willow sawdust and pretreated samples were analyzed with field emission scanning electron microscope and X-ray diffraction. The products in the sugar solution were determined as the total reducing sugars with the 3,5-dinitrosalicylic acid method and monosaccharides with capillary electrophoresis. According to the results, milling increased the sugar production, depending on the sulfuric acid load. T…
Investigation of a Gravel-Bed River’s Pattern Changes: Insights from Satellite Images
2021
Changes in river pattern have been documented in the literature. The recognition of islands and vegetated patches, which is indicative of the evolution processes, requires simultaneous information at different points and at different times and field studies are still difficult and scarce. The present work, focusing the attention on a gravel-bed river, explores the possibility to conduct a first-step pattern changes analysis by identifying the evolution of the morphological features and taking information of islands and vegetated patches from satellite images easily available from Google Earth. The study is conducted by combining the information taken from both the satellite images and the f…