Search results for "D23"
showing 10 items of 18 documents
A study of age-related IgE pathophysiological changes.
2003
Abstract The literature on immunosenescence has focused mainly on T cell impairment. However, it is well known that B function is also profoundly affected. In particular, several studies have shown age-related changes in immunoglobulin serum levels. Concerning allergic diseases, the incidence of onset of allergic symptoms, as well as their severity, seems to decrease with age. So, the decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total IgE due to an unbalance of cytokines and soluble factors involved in its production. To gain insight into the mechanisms of age related incidence of onset of allergic symptoms, as well as their severity, in thi…
Serum Levels of Soluble CD23 in Patients with Asthma or Rhinitis Monosensitive to Parietaria. Its Relation to Total Serum IgE levels and Eosinophil C…
1999
The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, we have analyzed, in blood from patients allergic to Parietaria sCD23, IgE, and eosinophil cationic protein (ECP) serum levels. IgE were assessed as atopy markers and ECP as an inflammation marker. Patients were studied during and out of pollen season, and results were compared to those obtained in nonallergic subjects. The study population included 42 nonsmoking outpatients, li…
Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: case …
2015
The synchronous occurrence of two different neoplasias is an uncommon event, which may arise between tumors originating in the same organ or in cancer-to-cancer metastasis. We report a rare case of chronic lymphocytic leukaemia / small lymphocytic lymphoma associated with a cutaneous metastatic squamous cell carcinoma in a cervical lymph node. In the affected lymph node, it was observed an effacement of the normal architecture by neoplastic lymphocytes and it was noted the presence of neoplastic invasive epithelial islands. Immunohistochemical analysis demonstrated that lymphocytic proliferation was positive for CD20, CD5, CD23 and Kappa, and negative for CD3, CD10, Cyclin D1 and Lambda. Th…
Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30
2010
Abstract Background To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV). Methods In a population-based study of 119 cKS cases, 105 KSHV-seropositive controls, and 155 KSHV-seronegative controls, we quantified plasma soluble cluster of differentiation (sCD) levels and antibodies against Epstein-Barr virus nuclear antigen-1 (anti-EBNA-1) and viral capsid antigen (anti-VCA). Differences between groups in prevalence of low-tertile anti-EBNA-1 and high-tertile anti-VCA were compared by logistic regression. Continuous levels between groups and by presence of cKS co-factors among controls were compared by li…
"Table 18" of "Jet mass and substructure of inclusive jets in $\sqrt{s}=7$ TeV $pp$ collisions with the ATLAS experiment"
2012
Normalised cross-section as a function of the the splitting scale variable sqrt(d23) of anti-kT jets with R=1.0.
"Table 19" of "Jet mass and substructure of inclusive jets in $\sqrt{s}=7$ TeV $pp$ collisions with the ATLAS experiment"
2012
Normalised cross-section as a function of the the splitting scale variable sqrt(d23) of anti-kT jets with R=1.0.
"Table 20" of "Jet mass and substructure of inclusive jets in $\sqrt{s}=7$ TeV $pp$ collisions with the ATLAS experiment"
2012
Normalised cross-section as a function of the the splitting scale variable sqrt(d23) of anti-kT jets with R=1.0.
"Table 17" of "Jet mass and substructure of inclusive jets in $\sqrt{s}=7$ TeV $pp$ collisions with the ATLAS experiment"
2012
Normalised cross-section as a function of the the splitting scale variable sqrt(d23) of anti-kT jets with R=1.0.
The structure of the moduli spaces of toric dynamical systems
2023
We consider complex-balanced mass-action systems, or toric dynamical systems. They are remarkably stable polynomial dynamical systems arising from reaction networks seen as Euclidean embedded graphs. We study the moduli spaces of toric dynamical systems, called the toric locus: given a reaction network, we are interested in the topological structure of the set of parameters giving rise to toric dynamical systems. First we show that the complex-balanced equilibria depend continuously on the parameter values. Using this result, we prove that the toric locus of any toric dynamical system is connected. In particular, we emphasize its product structure: it is homeomorphic to the product of the s…
Case report: Novel compound heterozygosity for pathogenic variants in MED23 in a syndromic patient with postnatal microcephaly
2023
Biallelic loss-of-function variants in MED23 cause a recessive syndromic intellectual disability condition with or without epilepsy (MRT18). Due to the small number of reported individuals, the clinical phenotype of the disorder has not been fully delineated yet, and the spectrum and frequency of neurologic features have not been fully characterized. Here, we report a 5-year-old girl with compound heterozygous for two additional MED23 variants. Besides global developmental delay, axial hypotonia and peripheral increased muscular tone, absent speech, and generalized tonic seizures, which fit well MRT18, the occurrence of postnatal progressive microcephaly has been here documented. A retrospe…