Search results for "DAA"

Transmediating argumentation : Students composing across written essays and digital videos in higher education

2016

This comparative study examined how university students built an argument in written essays and multimodal digital videos, and how their argumentation transmediated across these two mediums. Data analysis involved 1) analysis of content in both written essays and digital videos; 2) the development of transmediation visualizations to elucidate how ideas were transformed from essays into videos; and 3) multimodal analysis to understand the communicative affordances and constrains for argumentation with each medium. The findings revealed that the most common type of content in both essays and videos was supportive argumentation; however, the videos did not include any counter-argumentation. St…

Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens

2017

Background Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinations to evaluate their mode of action and cytotoxicity compared with telaprevir (TVR)+PR. Study design Mathematical modeling of ALT and HCV-RNA kinetics was performed in 111 HCV-1 cirrhotic patients, 81 treated with all-DAA regimens and 30 with TVR+PR. Kinetic-models and Cox-analysis were used to assess determinants of ALT-decay and normalization. Results HCV-RNA kinetics was biphasic, reflecting …

Direct acting antivirals after successful treatment of early hepatocellular carcinoma improve survival in HCV-cirrhotic patients

2019

Background & aims: The effectiveness of direct-acting antivirals (DAAs) against hepatitis C virus (HCV) after successful treatment of early hepatocellular carcinoma (HCC) has been studied extensively. However, the benefit in terms of overall survival (OS) remains to be conclusively demonstrated. The aim of this study was to assess the impact of DAAs on OS, HCC recurrence, and hepatic decompensation. Methods: We enrolled prospectively 163 consecutive patients with HCV-related cirrhosis and at first diagnosis of early Barcelona Clinic Liver Cancer (BCLC) 0/A HCC who had achieved a complete radiologic response after curative resection or ablation, subsequently treated with DAAs. DAA-untrea…

Resdagböcker på Internet som en kommunikativ genre

2012

"Me" : solidaarisuus, polarisaatio ja poteroituminen

2019

Learning cultural literacy through creative practices in schools cultural and multimodal approaches to meaning-making

2022

Introduction: Cultural Literacy and Creativity -- A Sociocultural Approach to Children’s Visual Creations -- Multimodality: Art as a Meaning-Making Process -- Tolerance, Empathy, and Inclusion -- Living Together -- Social Responsibility -- Belonging and Home -- Cultural Literacy During COVID-19 -- Conclusions: Cultural Literacy in Action -- Index. This open access book discusses how cultural literacy can be taught and learned through creative practices. It approaches cultural literacy as a dialogic social process based on learning and gaining knowledge through emphatic, tolerant, and inclusive interaction. The book focuses on meaning-making in children and young people’s visual and multimod…

Individual and Collaborative Semiotic Work in Document Design

2017

This article examines the concepts of agency, transformation and transduction in the context of document design. These concepts have been previously used to describe communicative actions and sign-making among individuals: whereas agency focuses on the individual’s capabilities as a sign-maker, transformation and transduction describe how individuals transform meanings within one mode of communication or from one mode to another. Organizational communication, however, is rarely an individual effort, particularly in corporate settings: producing multimodal documents that communicate on behalf of entire organizations, such as annual reports, constitutes a collaborative effort involving a vari…

Book review : David Machin (ed.), Visual Communication

2016

Sisäkorvaistutetta käyttävien lasten viittomakielen ja puhutun kielen omaksuminen

2013

Artikkeli kasittelee suomalaisen viittomakielen ja suomen kielen kehitysta kuudella kuurolla sisakorvaistutetta kayttavalla lapsella. Lasten kuulevat vanhemmat alkoivat opiskella ja kayttaa viittomakielta lastensa kanssa kuulovammadiagnoosin selvittya. Aineisto on keratty vuosina 2005 ja 2006 kuvanauhoittamalla lapsen ja viittomakielisen aikuisen seka lapsen ja suomenkielisen aikuisen vuorovaikutustilanteita. Lasten iat vaihtelivat 2;9 vuodesta 7;6 vuoteen tutkimuksen alussa. Taustatietoa saatiin haastattelemalla vanhempia. Kieliaineistoista analysoitiin molempien kielien sanastoa, ilmausten pituutta, nominaalien ja verbaalien taivutusta, artikulaatiota, aikuisen puheen/viittomisen ymmartam…

Openings in technology-mediated business meetings

2015

The prerequisites for opening a meeting, or beginning any kind of interaction for that matter, are participants’ presence and shared orientation towards the situation at hand. This paper analyses how the initial moments of technology-mediated business meetings involving distributed work groups are organized sequentially and multimodally. Drawing on video-recorded meetings in an international company, it documents the multimodal practices used in the process of establishing co-orientation to the shared meeting space and achieving entry into the meeting. The analysis shows that the stepwise unfolding of the opening phase requires the coordination of verbal and bodily conducts as well as the a…