Search results for "DAA"
showing 10 items of 231 documents
I know what i like when i see it:Likability is distinct from pleasantness since early stages of multimodal emotion evaluation
2021
Liking and pleasantness are common concepts in psychological emotion theories and in everyday language related to emotions. Despite obvious similarities between the terms, several empirical and theoretical notions support the idea that pleasantness and liking are cognitively different phenomena, becoming most evident in the context of emotion regulation and art enjoyment. In this study it was investigated whether liking and pleasantness indicate behaviourally measurable differences, not only in the long timespan of emotion regulation, but already within the initial affective responses to visual and auditory stimuli. A cross-modal affective priming protocol was used to assess whether there i…
Täpläravun (Pacifastacus leniusculus) vaikutus Säkylän Pyhäjärven siian poikastuotantoon
2015
Täplärapu (Pacifastacus leniusculus) on vieraslaji, mutta sitä on istutettu paljon suomalaisiin vesistöihin etenkin rapuruton hävittämien jokirapukantojen tilalle. Kalataloudellisesti täpläravun merkitys on nykyään huomattava. Täpläravun vaikutusta kalalajeihin on tutkittu vähän. Säkylän Pyhäjärvellä täplärapukanta on kasvanut nopeasti 2000-luvulla, mutta samalla myös siikapopulaatio on heikentynyt huomattavasti. Tässä tutkimuksessa selvitettiin täpläravun vaikutusta siikapopulaatioon vuosina 1998–2010. Täpläravut voivat käyttää kalojen mätiä ravinnokseen, ja suurissa tiheyksissä ravut saattavatkin saalistuksellaan vaikuttaa negatiivisesti siikojen mädin säilyvyyteen. Kohorttianalyysin avul…
Resistance test guided retreatment of HCV infected patients with a previous failure to a NS5A inhibitor-containing regimen: the Italian Vironet C rea…
2019
Previous article in issueNext article in issue Introduction: There is a limited documentation about the retreatment of patients failing a recommended NS5A-containing regimen in Italy. Materials & methods: Within the VIRONET-C network, 386 NS5A-failing patients infected with different HCV-genotypes (GT) (GT1a/1b/2a-c/3a-b-g-h/4a-d-n-o-v=93/124/19/112/38) were analyzed. Retreatment of 105 failures was investigated. HCV-resistance-test was performed by Sanger-sequencing. Results: Failures following seven different NS5A-containing regimens were studied: 3D/2D (paritaprevir/ombitasvir ± dasabuvir) ± ribavirin (N = 72/4), daclatasvir/ledipasvir/velpatasvir + sofosbuvir ± ribavirin (N = 105/13…
Schnittlinien Zwischen Stadt und Land. Rural-urban intersections. Between Contemporary urban and rural spaces
2017
From December to April 2015 I was in Hannover for a postdoctoral period founded by DAAD. I was continued a study about contemporary territories and villages, started at University of Palermo and regarding western Sicilian areas. I found Jörg Schröder’s researches (LUH - Chair for Regional Building and Urban Planning) a lush field to compare cases and methods. In that period Prof. Schröder with his team were studying Hamburg Metropolitan Region (Regiobranding - Branding of rural-urban regions through cultural landscape characteristics). I participated in the surveys in Steinburg district, at the mouth of the Elbe. An agricultural area large more than 50,000 hectares has been observed. The ur…
I sistemi delle classi d’età. Il contributo teorico di Bernardo Bernardi e la loro riscoperta contemporanea in chiave identitaria e patrimoniale
2020
This chapter considers Bernardi’s contribution to two different processes of traditional institutions revival in East Africa. He was the main ethnographer of the Mugwe, a traditional dignitary of the Meru of Kenya, that ceased to exist soon after his field work. He used the attribution ‘failing prophet’ in the title of the first edition of his book, changed into ‘blessing prophet’ in the following edition, having in the meanwhile registered a growing symbolic consideration for the institution. The history of the gadaa generational class system of the Oromo is intertwined with the Oromo liberation struggle. The institution never disappeared entirely, having remained operative among the Oromo…
Phylodynamic Analysis and Implication of HCV Genotype 4 Variability on Antiviral Drug Response and T-Cell Recognition.
2020
Therapies for HCV care could change the prevalence and the geographic distribution of genotypes due to differences in Sustained Virologic Response (SVR). In this scenario, uncommon genotypes/subtypes, such as genotype 4, could spread from high-risk groups, replacing genotypes eradicated by antiviral drugs. Genotype eradication is also strongly influenced by the CD8+ T cell response. In this study, the genetic variability in HCV genotype 4 strains obtained from a cohort of 67 patients naï
Effects of direct-acting antiviral therapy (DAAS) on the ultrasound parameters of portal hypertension
2018
Background:Among the endpoints of antiviral therapy with DAAs in HCV related liver cirrhosis (LC-HCV) in addition to the eradication of the virus there are the regression of fibrosis and of portal hypertension. For this reason we evaluated in LC-HCV patients and sustained virological response (SVR) to DAAs therapy the behavior of the AST to Platelet Ratio Index (APRI) (indirect marker of fibrosis) and of two ultrasound (US) signs of portal hypertension: caliber of the portal vein (cPV ) and longitudinal diameter of the spleen (LDS) Methods:132 patients with LC-HCV at baseline (BL), at three months (PostT3) and 12 months (PostT12) after the end of therapy, performed liver function tests and …
Platelet changes in patients with hepatitis C virus-related liver cirrhosis after directly acting antiviral therapy
2017
Background and Purpose of the study:Thrombocytopenia is the most common haematological abnormality in patients with Liver Cirrhosis and it is caused by multiple factors. This study evaluated platelets (PLT) count changes in patients with HCV related LC after DAAs therapy. Materials and Methods: We enrolled 83 patients with LC. In all patients were evaluated liver function tests and PLT count at baseline (BL), at end of therapy (ET) and three months post treatment (PostT), Elastography and ultrasound (US) at BL, and US at PostT. LC diagnosis was histological in 13 patients, in 71 with liver stiffness >12 kPa. All patients were SVR (58 patients had DAAs therapy without, 25 with Ribavirin).…
MODIFICAZIONI ECOGRAFICHE DELLA LINFADENOPATIA DELL’ILO EPATICO DOPO ERADICAZIONE DELL’HCV CON DIRECT-ACTING ANTIVIRALS
2019
A) Valutare le modificazioni ecografiche (US) dei linfonodi (LN) dell’ilo epatico in pazienti con epatopatia cronica (EC) correlata al virus dell’epatite C (HCV) e Sustained Virological Responders (SVR) alla terapia con i Direct-Acting Antivirals (DAAs); B) rilevare i fattori predittivi correlati con la scomparsa di LN. Abbiamo studiato 177 pazienti, trattati con DAAs, arruolati consecutivamente tra il Gennaio 2015 e il Dicembre 2016, con un follow-up dell’SVR di 24 mesi (SVR24) a Dicembre 2018; erano esclusi i pazienti con storia o insorgenza di epatocarcinoma nel follow-up. I LN erano definiti ingranditi (LN+) se il diametro maggiore era >1 cm. Al baseline (BL) registravamo: età, sesso…
Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluat…
2017
Background: Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure. Aim: To evaluate DAA failure incidence and the retreatment clinical impact in patients treated in the advanced liver disease stage. Methods: Data on HCV genotype, liver disease severity, and first and second line DAA regimens were prospectively collected in consecutive patients who reached the 12-week post-treatment and retreatment evaluations from January 2015 to December 2016 in 23 of the PITER network centers. Results: Among 3,830 patients with advanced fibrosis (F3) or cirrhosis, 139 (3.6%) failed to achieve SVR. Genotype 3, bilirubin lev…