Search results for "DAMAGE"

Fibre break failure processes in unidirectional composites: evaluation of critical damage states

2016

Earlier work which successfully modelled the kinetics of fibre breakage in unidirectional composites under monotonic tensile loading has been extended to quantify the kinetics of fibre failure during both monotonic and sustained tensile loading. In both cases, failure was seen to occur when a critical density of large clusters (more than 16 fibres are broken within the representative volume element) of fibre breaks developed. However, in monotonic loading failure occurred very quickly after the first development of these large clusters, whereas under sustained loading the composite could accommodate greater levels of large clusters because of the lower applied load. This article is part of …

Sterigmatocystin: Occurrence, toxicity and molecular mechanisms of action – A review

2020

The mycotoxin sterigmatocystin (STE) is produced mainly by Aspergillus fungi. It has been reported to occur in grains and grain-based products, cheese, coffee, spices and beer. The STE is a known biogenic precursor of aflatoxin B1, sharing with it several structural and biological similarities. The STE has been shown to be hepatotoxic and nephrotoxic in animals and it has been classified as possible human carcinogen (group 2B) by IARC. The STE has been reported to cause a marked decrease in cell proliferation in different mammalian cells. Data available on literature suggest that the cellular mechanisms underlying STE-induced toxicity include the induction of oxidative stress, mitochondrial…

2013

Following traumatic brain injury (TBI) neuroinflammatory processes promote neuronal cell loss. Alpha-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties, which may offer neuroprotection. Due to short half-life and pigmentary side-effects of α-MSH, the C-terminal tripeptide α-MSH(11–13) may be an anti-inflammatory alternative. The present study investigated the mRNA concentrations of the precursor hormone proopiomelanocortin (POMC) and of melanocortin receptors 1 and 4 (MC1R/MC4R) in naive mice and 15 min, 6, 12, 24, and 48 h after controlled cortical impact (CCI). Regulation of POMC and MC4R expression did not change after trauma, while MC1R levels incr…

Danno ambientale e risarcimento del danno all'immagine delle isole minori (parte prima)

2014

The contribution analyzes the elements of the damage to the image caused by environmental damage

An evolutionary perspective on stress responses, damage and repair

2022

Variation in stress responses has been investigated in relation to environmental factors, species ecology, life history and fitness. Moreover, mechanistic studies have unravelled molecular mechanisms of how acute and chronic stress responses cause physiological impacts (‘damage’), and how this damage can be repaired. However, it is not yet understood how the fitness effects of damage and repair influence stress response evolution. Here we study the evolution of hormone levels as a function of stressor occurrence, damage and the efficiency of repair. We hypothesise that the evolution of stress responses depends on the fitness consequences of damage and the ability to repair that damage. To o…

Vesiupotusmenetelmien vaikutus fyysisestä kuormituksesta palautumiseen miehillä

2017

Johdanto. Palautuminen on tärkeää erityisesti urheilijoiden harjoittelun ja kilpailujen yhteydessä. Sitä tapahtuu harjoituksen tai kilpailun aikana, välittömästi harjoituksen tai kilpailun jälkeen ja pitkäkestoisena harjoitusten ja kilpailujen välillä. Erilaisia palautumismenetelmiä on lukuisia ja niistä tärkeimpiä ovat aktiiviset menetelmät kuten kevyt aerobinen kuormitus sekä liikkuvuusharjoitukset. Passiivisia menetelmiä ovat uni, ravinto (nesteytys), hieronta, fysioterapia, painemenetelmät, lämpömenetelmät ja kylmäkäsittely. Tämän tutkimuksen tarkoitus oli selvittää aktiivisen palautumisen jälkeen suoritettujen eri vesiupotusmenetelmien sekä pelkän aktiivisen palautumisen vaikutusta fyy…

A cost efficiency analysis of flood proofing measures for hydraulic risk mitigation in an Urbanized riverine area

2020

Non-structural measures for flood risk mitigation are often more economically accessible, easier to implement, and are highly effective, especially in view of the pursuit of risk resilience objectives. Among the non-structural measures, more importance is increasingly being attributed to flood proofing interventions. There are two main types of flood proofing: dry proofing and wet proofing. An example of dry proofing is shielding, which involves the use of flood barriers that can be installed in the entrances of buildings or outside the buildings in order to avoid contact with the houses and deviate the water flow. Their use must be supported by a detailed hydraulic analysis to ensure the c…

Visual fields in a chloroquine treatment

2014

Purpose: In this study, we describe contrast sensitivity losses in the visual field of a patient affected by chloroquine toxicity, measured with stimuli favoring different visual mechanisms. We have compared these results with those of other, usual clinical tests. Methods: The vision of a patient who underwent ten years of chloroquine treatment was analyzed by a battery of clinical tests: visual acuity (VA), Amsler’s grid, Farnsworth–Munsell 100-hue test, spectral domain optical coherence tomography, multifocal electroretinogram (ERG), white-on-white and red-on-white Humphrey perimetries, chromatic and achromatic contrast sensitivity perimetry tests, and fluorescein angiography. Measurement…

Tectonothermal Evolution of the Broadly Rifted Zone, Ethiopian Rift

2019

The Broadly Rifted Zone (BRZ) of southern Ethiopia is a long-lived and structurally complex segment of the East African Rift System. However, due to poor surface exposure of early synrift strata and a dearth of subsurface data, the evolution of the BRZ remains poorly understood. We present new apatite (U-Th-Sm)/He and augmented apatite fission track low-temperature thermochronology data from the Beto and Galana basin boundary fault systems to constrain the tectonothermal evolution of the western and eastern BRZ, respectively. Time-temperature reconstructions suggest that East African Rift System-related extension began concurrently across the BRZ in the early Miocene (20–17 Ma), at least 6 …

Geomechanical Behavior of Shales

2016

The paper presents the recent advances and their relevance in the study of the geomechanical behavior of shales considering both experimental and modelling aspects. Shales are involved in several energy-related engineering applications where complex multiphysical conditions are encountered. Partial saturation, non-isothermal conditions, plasticity and damage mechanisms may have a fundamental impact on their geomechanical behavior. The relevance of these aspects for shales is presented in the paper both from advance experimental and modeling point of view.