Search results for "DAMAGE"

NEURAL CONTROL OF GAIT IN PEOPLE WITH HAEMOPHILIC ARTHROPATHY

2022

La hemofilia es un trastorno hemorrágico causado por una deficiencia de los factores VIII o IX de la coagulación. Las personas con hemofilia grave pueden tener hemorragias espontáneas o hemorragias en respuesta a traumatismos menores; la mayoría de los eventos ocurren en las articulaciones y los músculos. La manifestación clínica más frecuente es la artropatía hemofílica, que resulta del sangrado intraarticular repetitivo y de la membrana sinovial inflamada, lo que puede resultar en dolor crónico y deterioro articular. El objetivo general de mi tesis fue investigar el control neural de la marcha en personas con artropatía hemofílica (PCAH). La hipótesis de mi tesis fue que control neural de…

The Damage Caused by Anticompetitive Practices. Effective Methods and Techniques of Quantification

2020

Analyzing the impact of competition policy, the effects of anti-competitive practices and the decisions of competition authorities is a constant concern. Thus, public authorities, and especially competition authorities seek to justify the use of public resources to promote competition policy. Business representatives and international bodies seek to standardize competition rules so that they do not harm business development and others. In this regard, there are several methods and techniques applied to quantify the harm caused by anti-competitive practices, the economic effects of competition policy and the intervention of competition authorities proposed by the European Commission, the OEC…

The Strategy of Harm Reduction in Work with People Addicted to Drugs and Alcohol

2016

The policy of EU Member States, the United States, South America and Australia is heading towards the restructuring of the support system for addicts by implementing actions meant to limit the health and social damages resulting from the use of psychoactive substances. Many countries offer access to low-threshold programmes whereby the participant is not forced to maintain abstinence or submit to the excessive rules and obligations of a rehabilitation center. Harm reduction is a philosophy based on pragmatic and realistic goals of working with addicts and users. It assumes that each change, even the smallest, is important and should be supported. Harm reduction programmes usually function i…

Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure

2015

The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and c…

Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome

2020

ABSTRACT Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among the known causes of Seckel syndrome. However, it remains unclear how their deficiency disrupts the development and function of the central nervous system (CNS). Here, we investigated the cellular and molecular consequences of ATRIP deficiency in different cell populations of the developing murine neural retina. We discovered that conditional inactivation of Atrip in photoreceptor neurons …

External Load Variables Affect Recovery Markers up to 72 h After Semiprofessional Football Matches.

2019

Background: Player tracking devices are commonly used to monitor external load from training and matches in team sports. Yet, how the derived external load variables relate to fatigue and recovery post-training or post-match is scarcely researched. The objective was, therefore, to investigate how external load variables affect recovery markers up to 72 h post-match. Methods: Semiprofessional players from six teams wore tracking devices during three experimental football matches. External load variables including individual playing duration, total distance, PlayerLoad™, high-intensity running, and high-intensity events were derived from the tracking devices, and blood samples and performance…

Diabetic Kidney Disease and COVID-19: The Crash of Two Pandemics

2020

The difference of free light chains as a predictor of kidney damage in patients with Multiple Myeloma

2022


 Background: Multiple myeloma (MM) is a malignant neoplasm characterized by the clonal expansion of plasma cells that can release monoclonal immunoglobulins (monoclonal component) or part of theme. Since 2001, the k and λ serum free light chains (sFLC) evaluation and their ratio (rFLC) have made up the laboratory analysis more sensitive and precise in MM patients. The role of rFLC has been widely studied and discussed and now it is validated in the literature. Instead, the value of free light chains difference (dFLC), especially in MM is less known yet. The aim of this study is to evaluate the relationship between the dFLC and the kidney damage parameters in patients with MM, in compa…

Serratia marcescens infection or hypoxic-ischaemic encephalopathy in neonates: Is magnetic resonance imaging a problem-solving tool?

2017

To the Editor: We read with great interest the retrospective case series by A Madide and J Smith,[1] describing brain ultrasound (US) findings of neonates with Serratia marcescens hospital-acquired infections. S. marcescens is a Gram-negative organism that frequently colonises neonatal intensive care units (NICUs). This bacterium can cause severe brain infections in neonates, with irreversible neurological damage and long-term neurodevelopmental impairment. The authors conclude that in babies with acute onset of the illness, US scans allow doctors to highlight pathological changes in the brain immediately before the microbiological diagnosis of infection, and to follow the evolution of thos…

Il danno da lesione del rapporto parentale come danno evento esistenziale

2022

Il saggio propone una riflessione su quelle che appaiono come le nuove frontiere della discussa categoria del danno esistenziale che, seppure formalmente abbandonata, continua, secondo l’autore, a riconoscersi dietro la diversa etichetta del « danno dinamico relazionale ». Muovendo dalla figura del danno da lesione del rapporto parentale, quale ipotesi paradigmatica di danno esistenziale, l’autore propone una rilettura dell’intera categoria del danno esistenziale come danno evento. Questa interpretazione, secondo l’autore, è in grado di rispondere a molti degli interrogativi che le nuove figure emergenti dal dibattito giurisprudenziale sollevano. In questa prospettiva la ricostruzione del d…