Search results for "DAMAGE"
showing 10 items of 1289 documents
Heat shock protein 70 and exercise: morphofunctional relationships
2008
BEM analysis of a piezoelectric structural health monitoring system for delamination detection
2013
In the present work a piezoelectric based structural health monitoring (SHM) system is analyzed with the aim of assessing the ability of the piezoelectric patch to detect both edge and embedded delaminations proper of flange-skin composite laminated structures. he boundary element model is developed for piezoelectric solids and is implemented by taking advantage of the multidomain technique to model laminated and cracked configurations. A non-linear spring model interface is then implemented in conjunction with an iterative procedure allowing for the simulation of the finite stiffness of the bonding layers as well as of the non-penetration condition of the delamination surfaces. he dynamic …
Kilka uwag na temat odpowiedzialności deliktowej pomocnika
2014
Mechanizm neuroplastyczności i jego znaczenie dla psychoterapii oraz oceny jej skuteczności
2016
The paper introduces the mechanism of neuroplasticity, specifically the ability of the brain to develop new neurons (neurogenesis) and new connections between nerve cells (synaptogenesis) and to develop glial cells. The author presents the evidence proving the existence of neuroplasticity by giving examples of people with serious brain damage who function normally and, above all, of people living with almost no brain or with one hemisphere, or with post-stroke defects. However, the main purpose of this paper is to present the current state of knowledge of the importance of the brain plasticity for the course of psychotherapy, as well as for assessing its effectiveness. The author gives many…
LA CLASS ACTION E LA FUNZIONE DI DETERRENZA DEGLI ILLECITI CIVILI IN PROSPETTIVA COMPARATISTICA
2011
La ricerca affronta l'esame dell'istituto della class action o azione collettiva risarcitoria da tempo esistente nel sistema americano e di recente recepito nell'ordinamento italiano, attraverso la L.23 luglio 2009 n.99, che ha modificato la pregressa disciplina di cui all'art.2 comma 446 della L. 24 dicembre 2007 n.244 (finanziaria 2008), sia pur con alcune rilevanti differenze rispetto al sistema americano che ne riducono le potenzialità applicative (si consideri, ad es., la scelta italiana del sistema di opt-in piuttosto che del sistema di opt-out). Accanto alla class action - per l'analoga funzione di deterrenza - si esaminano i c.d. punitive damages o danni punitivi, per lungo tempo di…
Brevi note su alcune esperienze di trapianti giuridici in Europa
2016
The research aims to explain and illustrate the legal transplants theory, created by the well-known Scottish jurist Alan Watson, and tries to discover the foundation of its legitimacy in relation with some common law rules. In fact some relevant private law rules, which have been transplanted in more legal systems, will be examined so to underline the different impact of the same rule in different contexts for the deep influence of social, cultural and political factors on the legal principles. Specifically the different impact on legal systems of a particular civil action, the class action, born in Usa and circulated both in civil and in common law countries, will be examined. In the same …
INTEGRATED SYSTEMS IN PLANT PROTECTION MANAGEMENT: FIRE BLIGHT OF ROSACEOUS PLANTS (Erwinia amylovora (Burrill) - Winslow) IN AN APPLE ORCHARD IN SIB…
2013
Integrated protection represents a modern approach, denoting a protection strategy of agro-ecosystems; and it represents a complex system employing all appropriate methods in a manner as consistent and smooth as possible, in order to maintain the biocenotic balance of agrosystems and to keep pathogens at a level at which they do not cause economic damage (so-called level of eco-efficiency). A biocenotic approach to issues of agrosystem protection against disease attack requires an acknowledgement of all aspects regarding the evolution of pests in time and space, so as to be able to intervene at the right time with all possible means. And such protection measures are not supposed to restrain…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
2012
To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…