Search results for "DAMAGE"

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.

2014

Item does not contain fulltext Plasma triglyceride concentration is a biomarker for circulating triglyceride-rich lipoproteins and their metabolic remnants. Common mild-to-moderate hypertriglyceridaemia is typically multigenic, and results from the cumulative burden of common and rare variants in more than 30 genes, as quantified by genetic risk scores. Rare autosomal recessive monogenic hypertriglyceridaemia can result from large-effect mutations in six different genes. Hypertriglyceridaemia is exacerbated by non-genetic factors. On the basis of recent genetic data, we redefine the disorder into two states: severe (triglyceride concentration >10 mmol/L), which is more likely to have a mono…

Multiple Surface Cracking and Debonding Failure for Thin Thermal Coatings

2019

Abstract A mechanical analysis of thin films of quasi-brittle materials used as thermal coatings for superalloy substrate is proposed. The study considers a bi-material element subjected to uniform tension formed by a thin layer of quasi-brittle material (typically a ceramic) bonded on an elastic substrate. The bounding between the coating film and the substrate is realized by a very thin primer which mechanically modeled as a zero thickness cohesive frictional interface. The analysis is developed by a non-linear finite element simulation in which, in order to consider damage size effects, a non-local isotropic damage model is adopted for the quasi-brittle coating. The results of the analys…

PARP inhibitor resistance induces massive genome alterations responsible of the acquisition of multidrug resistance in DNA damage repair-deficient pa…

2020

Recognition and classification of external skin damage in citrus fruits using multispectral data and morphological features

2009

The computer vision systems currently used for the automatic inspection of citrus fruits are normally based on supervised methods that are capable of detecting defects on the surface of the fruit but are unable to discriminate between different types of defects. identifying the type of the defect affecting each fruit is very important in order to optimise the marketing profit and to be able to take measures to prevent such defects from occurring in the future. In this paper, we present a computer vision system that was developed for the recognition and classification of the most common external defects in citrus. in order to discriminate between 11 types of defects, images of the defects we…

Protective Effects of Foam Rolling against Inflammation and Notexin Induced Muscle Damage in Rats

2019

It is known that high-intensity exercise can cause inflammation and damage in muscle tissue, and in recent years, physical therapists and fitness professionals have begun to use foam rolling as a recovery method to improve performance. Despite the lack of basic science studies to support or refute the efficacy of foam rolling, the technique is very widely used in the sports world. In this respect, we investigated whether foam rolling could attenuate muscle damage and inflammation. Female Wistar rats were assigned to control (C), foam rolling (FR), notexin without foam rolling (N) and notexin with foam rolling (NFR) groups. A 4.5 x 2 cm foam roller was used to massage their hind legs (two 60…

Dépendance de la fatigue à la longueur musculaire : approche mécanique et neurophysiologique

2006

The objective of this work is to evaluate the fatigue dependency on the knee extensor muscles length. Exercises varying the type of contraction (isometric and eccentric) and intensity of contraction (maximal and sub-maximal) are performed in order to disrupt the neuromuscular system by different factors of fatigue: central and peripheral. These exercises are performed at two muscular lengths (S and L, corresponding respectively to 40 and 100° of knee flexion). Neuromuscular parameters (maximal torque, muscular twitch, voluntary activation level, electromyographic activity, etc.) are analyzed in pre- and post-fatigue conditions in the type of contraction required by the fatiguing exercise. I…

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

2014

SIRT1 is an important regulator of cellular stress response and genomic integrity. Its role in tumorigenesis is controversial. Whereas sirtuin 1 (SIRT1) can act as a tumor suppressor in some solid tumors, increased expression has been demonstrated in many cancers, including hematologic malignancies. In chronic myeloid leukemia, SIRT1 promoted leukemia development, and targeting SIRT1 sensitized chronic myeloid leukemia progenitors to tyrosine kinase inhibitor treatment. In this study, we investigated the role of SIRT1 in acute myeloid leukemia (AML). We show that SIRT1 protein, but not RNA levels, is overexpressed in AML samples harboring activating mutations in signaling pathways. In FMS-l…

Short‐term e‐cigarette vapor exposure causes vascular oxidative stress and dysfunction ‐ evidence for a close connection to brain damage and a key ro…

2020

A continuum damage model for functionalized graphene membranes based on atomistic simulations

2017

A continuum model for GO membranes is developed in this study. The model is built representing the membrane as a two-dimensional, heterogeneous, two-phase continuum and the constitutive behavior of each phase (graphitic or oxidized) is built based on DFTB simulations of representative patches. A hyper-elastic continuum model is employed for the graphene areas, while a continuum damage model is more adequate for representing the behavior of oxidized regions. A finite element implementation for GO membranes subjected to degradation and failure is then implemented and, to avoid localization instabilities and spurious mesh sensitivity, a simple crack band model is adopted. The developed impleme…

Redox signaling in acute pancreatitis

2015

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…