Search results for "DAMAGE"
showing 10 items of 1289 documents
Liver and Statins: A Critical Appraisal of the Evidence.
2019
Adverse drug reactions (ADRs) represent an important cause of morbidity and mortality worldwide. Statins are a class of drugs whose main adverse effects are drug-induced liver injury (DILI) and myopathy. Some of these may be predictable, due to their pharmacokinetic and pharmacodynamic properties, while others, unfortunately, are idiosyncratic. Genetic factors may also influence patient susceptibility to DILI and myopathy in the case of statins. This review will first discuss the role of statins in cardiovascular disease treatment and prevention and the underlying mechanisms of action. Furthermore, to explore the susceptibility of statin-induced adverse events such as myopathy and hepatoto…
INVERSE RELATIONSHIP BETWEEN CHOROIDAL THICKNESS AND SUBCLINICAL RENAL DAMAGE IN ESSENTIAL HYPERTENSION
2018
The introduction in last years of advanced techniques of optical coherence tomography (OCT) has greatly increased our understanding of the choroid, that is the most important vascular layer of the eye. Our study was aimed to assess choroidal thickness by using Swept-Source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without subclinical renal damage (SRD). We enrolled 100 EHs of which 65 without kidney damage and 35 with SRD. In all the participants SS-OCT and a routine biochemical workup were performed. Glomerular filtration rate (GFR) was estimated by the CKD-EPI equation (eGFR). SRD was defined, by the presence of microalbuminuria or eGFR between 30 and 60 mL/min/1.73 m…
[OP.3B.03] INFLUENCE OF SUBCLINICAL RENAL DAMAGE ON EARLY VASCULAR AGING IN PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS
2016
Objective: It is well known that kidney is frequently involved in patients with Systemic Lupus Erythematosus (SLE) However, conflicting data exist about the impact of renal involvement on vascular damage in this group of patients. The aim of this study was to evaluate the influence of renal damage on assessed by aortic pulse wave velocity (aPWV), evaluated a by intima-media thickness (IMT) measurement and assessed by renal resistive index (RRI) measurement, in patients with SLE. Design and method: We enrolled 52 SLE subjects (mean age 39 +/- 12 years), divided in two subgroups according to ACR/SLICC classification: patients with lupus nephritis, (LNG), and individuals presenting other featu…
SUBCLINICAL RENAL DAMAGE IS ASSOCIATED WITH A REDUCED CHOROIDAL THICKNESS IN PATIENTS WITH PRIMARY HYPERTENSION
2018
Objective: The retina is considered the easiest accessible window to study the state of the systemic microcirculation, even if the choroid is the most important vascular layer of the eye. Our understanding of the choroid has been greatly increased in last years since the introduction of advanced techniques of optical coherence tomography (OCT). Our study was aimed to assess choroidal thickness by using Swept-Source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without subclinical renal damage (SRD). Design and method: We enrolled 100 EHs of which 65 without kidney damage and 35 with SRD. In all the participants SS-OCT and a routine biochemical work-up were performed. Glomer…
[OP.7D.07] 24-HOUR CENTRAL BLOOD PRESSURE IS BETTER ASSOCIATED WITH TARGET ORGAN DAMAGE OF HYPERTENSION THAN BRACHIAL BLOOD PRESSURE
2017
Objective: The VASOTENS international, multicenter, observational, non-randomized, prospective study aims at evaluating the impact of 24-hour pulse wave analysis of ambulatory blood pressure (BP) recordings on target organ damage and cardiovascular prognosis of hypertensive patients. In the present analysis of study baseline data we checked whether organ damage of hypertension i) is better associated with 24-hour central than peripheral BP and ii) is related to ambulatory arterial stiffness, estimated by pulse wave velocity (PWV) and augmentation index (AIx). Design and method: In 334 hypertensive patients (mean age 53+/-15, 52% males, 45% treated) we obtained 24-hour ABPMs, echocardiograms…
Responsabilità per trattamenti tricologici: casistica ed indagine conoscitiva
2012
The Authors report two cases of refund claim of personal damages for presumed professional responsibility of hairdressers, related to professional activities for trichological procedures. In fact acquired data show that, in the last years, there are many claims, even in civil litigation, for presumed professional responsibility concerning cosmetic medical-surgical practices, but also of typically moving crafts, for activities performed by these professionals. So, for many aspects of these events, medical examiner, is involved in the evaluation of causation between performed activities and complained subsistence of sequelae that could be considered damage of good constitutionally protected. …
Biochemical Factors and Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma
1992
A distinction between primary and secondary manifestations of brain damage from acute insults, such as trauma, or ischemia is not only of scientific interest but also of the highest clinical significance. After all, prevention of secondary brain damage in patients with severe head injury or cerebral ischemia is the ultimate purpose of treatment, including the measures of emergency care. It can be assumed that the secondary sequelae of head injury are as important for the outcome as the primary insult is. Therefore, it is obvious that development of more effective forms of treatment requires a better understanding of the mechanisms underlying secondary brain damage. Manifestations of seconda…
Weak forms of shakedown for elastic-plastic structures exhibiting ductile damage
2001
A special weak-form shakedown is studied for elastic-plastic internal-variable material models with nonlinear hardening, damageable elastic moduli and damageable yield surface, in the hypothesis of ductile damage, (i.e. damage induced by plastic strains), but the precise evolutive law of damage being left unspecified. Sufficient weak-form shakedown theorems are presented, one static and another kinematic, each assessing whether eventually plastic deformations cease together with their consequences, including ductile damage. A two-sided delimitation is provided, within which the weak-form shakedown safety factor can be located. An upper bound to the post-transient damage for a particular iso…
Influence of custom-made and prefabricated insoles before and after an intense run
2017
[EN] Each time the foot contacts the ground during running there is a rapid deceleration that results in a shock wave that is transmitted from the foot to the head. The fatigue of the musculoskeletal system during running may decrease the ability of the body to absorb those shock waves and increase the risk of injury. Insoles are commonly prescribed to prevent injuries, and both custom-made and prefabricated insoles have been observed to reduce shock accelerations during running. However, no study to date has included a direct comparison of their behaviour measured over the same group of athletes, and therefore great controversy still exists regarding their effectiveness in reducing impact …
Gli ingegneri camerali in Sicilia dopo il terremoto del 1823
2016
La memoria intende indagare, attraverso lo studio delle fonti bibliografiche e soprattutto di una copiosa documentazione archivistica, il ruolo determinante svolto dalle istituzioni attraverso l’attività degli ingegneri camerali, tecnici alle dirette dipendenze dell’amministrazione regia, tra i quali emergono alcuni tra i professionisti più attivi del tempo quali Luigi Speranza, Giuseppe Patti e Alessandro Emmanuele Marvuglia. Questi ultimi vennero incaricati di effettuare numerosi sopralluoghi nelle zone colpite dal terremoto al fine di valutare e monitorare i danni, redigendo sia quadri di carattere generale relativi ai singoli centri, che perizie di dettaglio volte all’accertamento dei d…