Search results for "DAS"

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

2015

The modification of proteins by ubiquitin has a major role in cells of the immune system and is counteracted by various deubiquitinating enzymes (DUBs) with poorly defined functions. Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3β. Caspase-dependent processing of USP8 occurred after stimulation of the TCR. T cell-specific deletion of USP8 in mice revealed that USP8 was essential for thymocyte maturation and upregulation of the gene encoding the cytokine receptor IL-7Rα mediated by the transcription factor Foxo1. Mice with T cell-specifi…

Una aproximación volumétrica a la desagregación espacial de la población combinando cartografía temática y datos LIDAR

2016

[EN] Availability of high resolution population distribution data, independent of the administrative units in which demographic statistics are collected, is a real necessity in many fields: risk evaluation due to earthquakes, flooding or fires, to name just a few, integration between socio-demographic and environmental or geographical information collected in different formats, policy design for the provision public services, such as health, education or public transport, or mobility studies in urban areas or metropolitan regions. Because of this, the literature has explored various methods of population downscaling, collected at communality or census tract level, into smaller areas; typica…

A volumetric approach to spatial population disaggregation using a raster build-up layer, land use/land cover databases (SIOSE) and LIDAR remote sens…

2016

[EN] Availability of high resolution population distribution data, independent of the administrative units in which demographic statistics are collected, is a real necessity in many fields: risk evaluation due to earthquakes, flooding or fires, to name just a few, integration between socio-demographic and environmental or geographical information collected in different formats, policy design for the provision public services, such as health, education or public transport, or mobility studies in urban areas or metropolitan regions. Because of this, the literature has explored various methods of population downscaling, collected at communality or census tract level, into smaller areas; typica…

Linguistica Lettica, Nr. 8

2001

La didascalie des merveilles : récits et instructions des savants confrontés aux raretés de la nature à la fin de la Renaissance

2007

International audience

Brewer's spent grains as biofuels in combustion-based energy recovery processes: Evaluation of thermo-oxidative decomposition

2022

[EN] The high global generation of wastes and side streams from agri-food production has led to environmental impact and causes nature degradation due to their uncontrolled management. These wastes are profitable materials with significant economic value that could otherwise be exploited as new sources in the feed industry or the production of bioenergy. Among them, brewer¿s spent grain (BSG) is a solid by-product generated in the beerbrewing process that consists of the barley grain husks together with parts of the pericarp and seed coat layer. Although it is rich in fibres and proteins, its main use is currently limited to animal feed or simply deposition to landfills. This study pursues …

Johannesburgo, entre el escapismo y la estafa

2002

Diagnostic validity of ICDAS II, VistaProof and a combination of these two methods. An in vitro study in pre-cavitated lesions

2017

Purpose In view of the present fall in advanced cavitation lesion prevalence, diagnostic methods have been developed to assist in assessing and measuring pre-cavitation lesions. The purpose of this study was to assess the VistaProof fluorescence-based system in vitro and compare the results with those of visual examination using the ICDAS II criteria. Methods 100 permanent teeth were collected and 65 were chosen at random for this study. Two separate examiners each examined them twice, 3 weeks apart, assessing them in accordance with ICDAS II. They were subsequently examined with the VistaProof system and the images were stored in the computer program. After obtaining all these data, the te…

A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial

2021

Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency. Objective: To describe the occurrence of adverse events in PD patients treated with safinamide in real-life conditions. Methods: The SYNAPSES trial is an observational, European, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months with analyses performed in the overall population and in patients aged >75 years, with relevant comorbi…

Chemiluminescence response of ß-glucan stimulated leukocytes isolated from different tissues and peritoneal cavity of Dicentrarchus labrax

2003

Abstract The respiratory burst of leukocytes isolated from sea bass ( Dicentrarchus labrax ) pronephros, peritoneal cavity (P.C.), spleen and blood, was measured by a chemiluminescence (CL) assay after stimulation with β-glucan. The CL response by P.C. and pronephros leukocytes was significantly higher than that expressed by a similar number of cells separated from spleen and blood. This probably reflects the observation that the proportion of macrophages and neutrophils was highest in the populations of leukocytes from peritoneal cavity and pronephros. Comparative observations showed a higher degree of yeast phagocytosis by leukocytes taken from peritoneal cavity than the pronephros. Moreo…